OCA at 10:19, 22 May 2024

OCA — Wed, 22 May 2024 10:19:45 GMT

←Older revision		Revision as of 10:19, 22 May 2024
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-	====	+	==Structure of STENOFOLIA Protein HD domain bound with DNA==
-	<StructureSection load='6wig' size='340' side='right'caption='[[6wig]]' scene=''>	+	<StructureSection load='6wig' size='340' side='right'caption='[[6wig]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wig]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_truncatula Medicago truncatula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WIG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wig OCA], [https://pdbe.org/6wig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wig RCSB], [https://www.ebi.ac.uk/pdbsum/6wig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wig ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wig OCA], [https://pdbe.org/6wig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wig RCSB], [https://www.ebi.ac.uk/pdbsum/6wig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wig ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0ZGT3_MEDTR G0ZGT3_MEDTR]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Homeobox transcription factors are key regulators of morphogenesis and development in both animals and plants. In plants, the WUSCHEL-related homeobox (WOX) family of transcription factors function as central organizers of several developmental programs ranging from embryo patterning to meristematic stem-cell maintenance through transcriptional activation and repression mechanisms. The Medicago truncatula STENOFOLIA (STF) gene is a master regulator of leaf-blade lateral development. Here, the crystal structure of the homeodomain (HD) of STF (STF-HD) in complex with its promoter DNA is reported at 2.1 A resolution. STF-HD binds DNA as a tetramer, enclosing nearly the entire bound DNA surface. The STF-HD tetramer is partially stabilized by docking of the C-terminal tail of one protomer onto a conserved hydrophobic surface on the head of another protomer in a head-to-tail manner. STF-HD specifically binds TGA motifs, although the promoter sequence also contains TAAT motifs. Helix alpha3 not only serves a canonical role as a base reader in the major groove, but also provides DNA binding in the minor groove through basic residues located at its C-terminus. The structural and functional data in planta reported here provide new insights into the DNA-binding mechanisms of plant-specific HDs from the WOX family of transcription factors.
		+
		+	Structure of the unique tetrameric STENOFOLIA homeodomain bound with target promoter DNA.,Pathak PK, Zhang F, Peng S, Niu L, Chaturvedi J, Elliott J, Xiang Y, Tadege M, Deng J Acta Crystallogr D Struct Biol. 2021 Aug 1;77(Pt 8):1050-1063. doi:, 10.1107/S205979832100632X. Epub 2021 Jul 29. PMID:34342278<ref>PMID:34342278</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wig" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Medicago truncatula]]
		+	[[Category: Deng J]]
		+	[[Category: Pathak P]]
		+	[[Category: Peng S]]

OCA at 06:04, 11 August 2021

OCA — Wed, 11 Aug 2021 06:04:49 GMT

←Older revision		Revision as of 06:04, 11 August 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6wig ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6wig' size='340' side='right'caption='[[6wig]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wig OCA], [https://pdbe.org/6wig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wig RCSB], [https://www.ebi.ac.uk/pdbsum/6wig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wig ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:15, 22 April 2020

OCA — Wed, 22 Apr 2020 04:15:21 GMT

←Older revision		Revision as of 04:15, 22 April 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wig is ON HOLD	+	The entry 6wig is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6wig" [edit=sysop:move=sysop]

OCA — Wed, 15 Apr 2020 05:29:56 GMT

Protected "6wig" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:29, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wig is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Apr 2020 05:29:54 GMT

New page: '''Unreleased structure''' The entry 6wig is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6wig is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6wig - Revision history

OCA at 10:19, 22 May 2024

OCA at 06:04, 11 August 2021

OCA at 04:15, 22 April 2020

OCA: Protected "6wig" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6wig is ON HOLD Authors: Description: Category: Unreleased Structures