6wj0 - Revision history

OCA at 14:26, 18 October 2023

OCA — Wed, 18 Oct 2023 14:26:19 GMT

←Older revision		Revision as of 14:26, 18 October 2023
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-	====	+	==Crystal structure of Fab 54-4H03==
-	<StructureSection load='6wj0' size='340' side='right'caption='[[6wj0]]' scene=''>	+	<StructureSection load='6wj0' size='340' side='right'caption='[[6wj0]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WJ0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wj0 OCA], [~~http~~://pdbe.org/6wj0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wj0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wj0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wj0 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.802Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wj0 OCA], [https://pdbe.org/6wj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wj0 RCSB], [https://www.ebi.ac.uk/pdbsum/6wj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wj0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Understanding how broadly neutralizing antibodies (bnAbs) to influenza hemagglutinin (HA) naturally develop in humans is critical to the design of universal influenza vaccines. Several classes of bnAbs directed to the conserved HA stem were found in multiple individuals, including one encoded by heavy-chain variable domain VH6-1. We describe two genetically similar VH6-1 bnAb clonotypes from the same individual that exhibit different developmental paths toward broad neutralization activity. One clonotype evolved from a germline precursor recognizing influenza group 1 subtypes to gain breadth to group 2 subtypes. The other clonotype recognized group 2 subtypes and developed binding to group 1 subtypes through somatic hypermutation. Crystal structures reveal that the specificity differences are primarily mediated by complementarity-determining region H3 (CDR H3). Thus, while VH6-1 provides a framework for development of HA stem-directed bnAbs, sequence differences in CDR H3 junctional regions during VDJ recombination can alter reactivity and evolutionary pathways toward increased breadth.
		+
		+	Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor.,Wu NC, Andrews SF, Raab JE, O'Connell S, Schramm CA, Ding X, Chambers MJ, Leung K, Wang L, Zhang Y, Mascola JR, Douek DC, Ledgerwood JE, McDermott AB, Wilson IA Cell Host Microbe. 2020 Sep 9;28(3):434-444.e4. doi: 10.1016/j.chom.2020.06.003. , Epub 2020 Jul 2. PMID:32619441<ref>PMID:32619441</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wj0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Wilson IA]]
		+	[[Category: Wu NC]]

OCA at 11:29, 23 September 2020

OCA — Wed, 23 Sep 2020 11:29:27 GMT

←Older revision		Revision as of 11:29, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6wj0 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6wj0' size='340' side='right'caption='[[6wj0]]' scene=''>
-	~~Authors~~: ~~Wu, N~~.C.~~, Wilson, I~~.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of Fab 54~~-~~4H03~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wj0 OCA], [http://pdbe.org/6wj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wj0 RCSB], [http://www.ebi.ac.uk/pdbsum/6wj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wj0 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Wu, N.C~~]]	+	__TOC__
-	[[Category: ~~Wilson, I.A~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:12, 20 May 2020

OCA — Wed, 20 May 2020 04:12:30 GMT

←Older revision		Revision as of 04:12, 20 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wj0 is ON HOLD	+	The entry 6wj0 is ON HOLD until Paper Publication

	Authors: Wu, N.C., Wilson, I.A.		Authors: Wu, N.C., Wilson, I.A.

OCA: Protected "6wj0" [edit=sysop:move=sysop]

OCA — Wed, 22 Apr 2020 04:16:33 GMT

Protected "6wj0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 22 April 2020

OCA: New page: '''Unreleased structure''' The entry 6wj0 is ON HOLD Authors: Wu, N.C., Wilson, I.A. Description: Crystal structure of Fab 54-4H03 Category: Unreleased Structures [[Category: Wu, N...

OCA — Wed, 22 Apr 2020 04:16:32 GMT

New page: '''Unreleased structure''' The entry 6wj0 is ON HOLD Authors: Wu, N.C., Wilson, I.A. Description: Crystal structure of Fab 54-4H03 Category: Unreleased Structures [[Category: Wu, N...

New page

'''Unreleased structure'''

The entry 6wj0 is ON HOLD

Authors: Wu, N.C., Wilson, I.A.

Description: Crystal structure of Fab 54-4H03
[[Category: Unreleased Structures]]
[[Category: Wu, N.C]]
[[Category: Wilson, I.A]]