6woi - Revision history

OCA at 14:46, 6 March 2024

OCA — Wed, 06 Mar 2024 14:46:18 GMT

←Older revision		Revision as of 14:46, 6 March 2024
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	==Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate, Mg, and Fluoride ion, presoaked with 1,5-IP8, Mg and Fluoride for 30 seconds==		==Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate, Mg, and Fluoride ion, presoaked with 1,5-IP8, Mg and Fluoride for 30 seconds==
-	<StructureSection load='6woi' size='340' side='right'caption='[[6woi]]' scene=''>	+	<StructureSection load='6woi' size='340' side='right'caption='[[6woi]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WOI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6woi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WOI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6woi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6woi OCA], [https://pdbe.org/6woi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6woi RCSB], [https://www.ebi.ac.uk/pdbsum/6woi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6woi ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O81:(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl+trihydrogen+diphosphate'>O81</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6woi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6woi OCA], [https://pdbe.org/6woi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6woi RCSB], [https://www.ebi.ac.uk/pdbsum/6woi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6woi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NUDT3_HUMAN NUDT3_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.<ref>PMID:9822604</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Shears SB]]		[[Category: Shears SB]]
	[[Category: Wang HC]]		[[Category: Wang HC]]
	[[Category: Zong GN]]		[[Category: Zong GN]]

OCA at 14:42, 3 March 2021

OCA — Wed, 03 Mar 2021 14:42:04 GMT

←Older revision		Revision as of 14:42, 3 March 2021
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-	'''Unreleased structure'''

-	~~The entry 6woi is ON HOLD until Paper Publication~~	+	==Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate, Mg, and Fluoride ion, presoaked with 1,5-IP8, Mg and Fluoride for 30 seconds==
-		+	<StructureSection load='6woi' size='340' side='right'caption='[[6woi]]' scene=''>
-	~~Authors: Zong, G.N., Wang, H.C., Shears, S.B.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WOI FirstGlance]. <br>
-	~~Description:~~ Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate, Mg, and Fluoride ion, presoaked with 1,5-IP8, Mg and Fluoride for 30 seconds	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6woi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6woi OCA], [https://pdbe.org/6woi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6woi RCSB], [https://www.ebi.ac.uk/pdbsum/6woi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6woi ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Zong, G.N~~]]	+	__TOC__
-	[[Category: Wang~~, H.C~~]]	+	</StructureSection>
-	[[Category: ~~Shears, S.B~~]]	+	[[Category: Large Structures]]
		+	[[Category: Shears SB]]
		+	[[Category: Wang HC]]
		+	[[Category: Zong GN]]

OCA at 08:32, 17 June 2020

OCA — Wed, 17 Jun 2020 08:32:52 GMT

←Older revision		Revision as of 08:32, 17 June 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6woi is ON HOLD	+	The entry 6woi is ON HOLD until Paper Publication

	Authors: Zong, G.N., Wang, H.C., Shears, S.B.		Authors: Zong, G.N., Wang, H.C., Shears, S.B.

OCA at 04:03, 13 May 2020

OCA — Wed, 13 May 2020 04:03:35 GMT

←Older revision		Revision as of 04:03, 13 May 2020
Line 5:		Line 5:
	Authors: Zong, G.N., Wang, H.C., Shears, S.B.		Authors: Zong, G.N., Wang, H.C., Shears, S.B.

-	Description: Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate ~~(IP8 soaking)~~, Mg, and Fluoride ion	+	Description: Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate, Mg, and Fluoride ion, presoaked with 1,5-IP8, Mg and Fluoride for 30 seconds
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zong, G.N]]		[[Category: Zong, G.N]]
	[[Category: Wang, H.C]]		[[Category: Wang, H.C]]
	[[Category: Shears, S.B]]		[[Category: Shears, S.B]]

OCA: Protected "6woi" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2020 04:26:09 GMT

Protected "6woi" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:26, 6 May 2020

OCA: New page: '''Unreleased structure''' The entry 6woi is ON HOLD Authors: Zong, G.N., Wang, H.C., Shears, S.B. Description: Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in comp...

OCA — Wed, 06 May 2020 04:26:06 GMT

New page: '''Unreleased structure''' The entry 6woi is ON HOLD Authors: Zong, G.N., Wang, H.C., Shears, S.B. Description: Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in comp...

New page

'''Unreleased structure'''

The entry 6woi is ON HOLD

Authors: Zong, G.N., Wang, H.C., Shears, S.B.

Description: Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate (IP8 soaking), Mg, and Fluoride ion
[[Category: Unreleased Structures]]
[[Category: Zong, G.N]]
[[Category: Wang, H.C]]
[[Category: Shears, S.B]]