OCA at 14:32, 18 October 2023

OCA — Wed, 18 Oct 2023 14:32:17 GMT

←Older revision		Revision as of 14:32, 18 October 2023
Line 1:		Line 1:

-	====	+	==Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 251249==
-	<StructureSection load='6woz' size='340' side='right'caption='[[6woz]]' scene=''>	+	<StructureSection load='6woz' size='340' side='right'caption='[[6woz]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6woz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WOZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6woz OCA], [https://pdbe.org/6woz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6woz RCSB], [https://www.ebi.ac.uk/pdbsum/6woz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6woz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6woz OCA], [https://pdbe.org/6woz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6woz RCSB], [https://www.ebi.ac.uk/pdbsum/6woz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6woz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A5K736_PLAVS A5K736_PLAVS]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium vivax preferentially invades reticulocytes and recognition of these cells is mediated by P. vivax Reticulocyte Binding Protein 2b (PvRBP2b) binding to human Transferrin receptor 1 (TfR1) and Transferrin (Tf). Longitudinal cohort studies in Papua New Guinea, Thailand and Brazil show that PvRBP2b antibodies are correlated with protection against P. vivax infection and disease. Here, we isolate and characterize anti-PvRBP2b human monoclonal antibodies from two individuals in Cambodia with natural P. vivax infection. These antibodies bind with high affinities and map to different regions of PvRBP2b. Several human antibodies block PvRBP2b binding to reticulocytes and inhibit complex formation with human TfR1-Tf. We describe different structural mechanisms for functional inhibition, including either steric hindrance with TfR1-Tf or the reticulocyte membrane. These results show that naturally acquired human antibodies against PvRBP2b can inhibit its function which is important for P. vivax invasion.
		+
		+	Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.,Chan LJ, Gandhirajan A, Carias LL, Dietrich MH, Vadas O, Visentin R, Franca CT, Menant S, Soldati-Favre D, Mueller I, King CL, Tham WH Nat Commun. 2021 Mar 9;12(1):1538. doi: 10.1038/s41467-021-21811-2. PMID:33750786<ref>PMID:33750786</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6woz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Plasmodium vivax Sal-1]]
		+	[[Category: Chan LJ]]
		+	[[Category: Dietrich MH]]
		+	[[Category: Tham WH]]

OCA at 07:54, 27 January 2021

OCA — Wed, 27 Jan 2021 07:54:49 GMT

←Older revision		Revision as of 07:54, 27 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6woz ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6woz' size='340' side='right'caption='[[6woz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6woz OCA], [https://pdbe.org/6woz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6woz RCSB], [https://www.ebi.ac.uk/pdbsum/6woz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6woz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "6woz" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2020 04:27:54 GMT

Protected "6woz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 6 May 2020

OCA: New page: '''Unreleased structure''' The entry 6woz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 May 2020 04:27:52 GMT

New page: '''Unreleased structure''' The entry 6woz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6woz is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6woz - Revision history

OCA at 14:32, 18 October 2023

OCA at 07:54, 27 January 2021

OCA: Protected "6woz" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6woz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures