6wru - Revision history

OCA at 15:21, 8 June 2021

OCA — Tue, 08 Jun 2021 15:21:46 GMT

←Older revision		Revision as of 15:21, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='6wru' size='340' side='right'caption='[[6wru]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6wru' size='340' side='right'caption='[[6wru]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6wru]] is a 28 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WRU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6WRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wru]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WRU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U7Y:Tedizolid+isomer'>U7Y</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U7Y:Tedizolid+isomer'>U7Y</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6wqn\|6wqn]], [[6wqq\|6wqq]], [[6wrs\|6wrs]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6wqn\|6wqn]], [[6wqq\|6wqq]], [[6wrs\|6wrs]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6wru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wru OCA], [~~http~~://pdbe.org/6wru PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6wru RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6wru PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6wru ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wru OCA], [https://pdbe.org/6wru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wru RCSB], [https://www.ebi.ac.uk/pdbsum/6wru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wru ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/W8U3W0_STAAU W8U3W0_STAAU]] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01325][RuleBase:RU003906] [[~~http~~://www.uniprot.org/uniprot/A0A077UUA0_STAAU A0A077UUA0_STAAU]] Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.[HAMAP-Rule:MF_01367][RuleBase:RU003950] [[~~http~~://www.uniprot.org/uniprot/W8TRD5_STAAU W8TRD5_STAAU]] One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.[HAMAP-Rule:MF_01326] One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01326] [[~~http~~://www.uniprot.org/uniprot/A0A077W1J0_STAAU A0A077W1J0_STAAU]] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.[HAMAP-Rule:MF_01320] [[~~http~~://www.uniprot.org/uniprot/A0A077UGA7_STAAU A0A077UGA7_STAAU]] Binds to the 23S rRNA.[HAMAP-Rule:MF_01341][SAAS:SAAS00687840] [[~~http~~://www.uniprot.org/uniprot/A0A077UVB6_STAAU A0A077UVB6_STAAU]] This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.[HAMAP-Rule:MF_00402][RuleBase:RU000559] [[~~http~~://www.uniprot.org/uniprot/A0A166DK89_STAAU A0A166DK89_STAAU]] Forms part of the polypeptide exit tunnel.[HAMAP-Rule:MF_01328] One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.[HAMAP-Rule:MF_01328] [[~~http~~://www.uniprot.org/uniprot/A0A077V4G0_STAAU A0A077V4G0_STAAU]] Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.[HAMAP-Rule:MF_01342][RuleBase:RU004414] [[http://www.uniprot.org/uniprot/W8TRE0_STAAU W8TRE0_STAAU]] This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.[HAMAP-Rule:MF_01337] [[http://www.uniprot.org/uniprot/W8TUB4_STAAU W8TUB4_STAAU]] One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.[HAMAP-Rule:MF_01369] [[~~http~~://www.uniprot.org/uniprot/A0A077VMP6_STAAU A0A077VMP6_STAAU]] Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.[HAMAP-Rule:MF_00382][RuleBase:RU000560] [[~~http~~://www.uniprot.org/uniprot/W8TUE6_STAAU W8TUE6_STAAU]] This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.[HAMAP-Rule:MF_01366][RuleBase:RU003878][SAAS:SAAS00725369] [[~~http~~://www.uniprot.org/uniprot/A0A0E0VQU6_STAA5 A0A0E0VQU6_STAA5]] This protein binds to 23S rRNA in the presence of protein L20.[HAMAP-Rule:MF_01363][RuleBase:RU000562] [[~~http~~://www.uniprot.org/uniprot/W8U3X2_STAAU W8U3X2_STAAU]] This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.[HAMAP-Rule:MF_01365][RuleBase:RU003870] [[~~http~~://www.uniprot.org/uniprot/A0A077UKF9_STAAU A0A077UKF9_STAAU]] The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.[HAMAP-Rule:MF_01331] This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.[HAMAP-Rule:MF_01331][RuleBase:RU004008]	+	[[https://www.uniprot.org/uniprot/W8U3W0_STAAU W8U3W0_STAAU]] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01325][RuleBase:RU003906] [[https://www.uniprot.org/uniprot/A0A077UUA0_STAAU A0A077UUA0_STAAU]] Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.[HAMAP-Rule:MF_01367][RuleBase:RU003950] [[https://www.uniprot.org/uniprot/W8TRD5_STAAU W8TRD5_STAAU]] One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.[HAMAP-Rule:MF_01326] One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01326] [[https://www.uniprot.org/uniprot/A0A077W1J0_STAAU A0A077W1J0_STAAU]] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.[HAMAP-Rule:MF_01320] [[https://www.uniprot.org/uniprot/A0A077UGA7_STAAU A0A077UGA7_STAAU]] Binds to the 23S rRNA.[HAMAP-Rule:MF_01341][SAAS:SAAS00687840] [[https://www.uniprot.org/uniprot/A0A077UVB6_STAAU A0A077UVB6_STAAU]] This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.[HAMAP-Rule:MF_00402][RuleBase:RU000559] [[https://www.uniprot.org/uniprot/A0A166DK89_STAAU A0A166DK89_STAAU]] Forms part of the polypeptide exit tunnel.[HAMAP-Rule:MF_01328] One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.[HAMAP-Rule:MF_01328] [[https://www.uniprot.org/uniprot/A0A077V4G0_STAAU A0A077V4G0_STAAU]] Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.[HAMAP-Rule:MF_01342][RuleBase:RU004414] [[https://www.uniprot.org/uniprot/W8TUB4_STAAU W8TUB4_STAAU]] One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.[HAMAP-Rule:MF_01369] [[https://www.uniprot.org/uniprot/W8TRE0_STAAU W8TRE0_STAAU]] This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.[HAMAP-Rule:MF_01337] [[https://www.uniprot.org/uniprot/A0A077VMP6_STAAU A0A077VMP6_STAAU]] Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.[HAMAP-Rule:MF_00382][RuleBase:RU000560] [[https://www.uniprot.org/uniprot/W8TUE6_STAAU W8TUE6_STAAU]] This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.[HAMAP-Rule:MF_01366][RuleBase:RU003878][SAAS:SAAS00725369] [[https://www.uniprot.org/uniprot/A0A0E0VQU6_STAA5 A0A0E0VQU6_STAA5]] This protein binds to 23S rRNA in the presence of protein L20.[HAMAP-Rule:MF_01363][RuleBase:RU000562] [[https://www.uniprot.org/uniprot/W8U3X2_STAAU W8U3X2_STAAU]] This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.[HAMAP-Rule:MF_01365][RuleBase:RU003870] [[https://www.uniprot.org/uniprot/A0A077UKF9_STAAU A0A077UKF9_STAAU]] The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.[HAMAP-Rule:MF_01331] This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.[HAMAP-Rule:MF_01331][RuleBase:RU004008]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:51, 16 December 2020

OCA — Wed, 16 Dec 2020 12:51:12 GMT

←Older revision		Revision as of 12:51, 16 December 2020
Line 1:		Line 1:

	==Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with an isomer of the tedizolid==		==Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with an isomer of the tedizolid==
-	<StructureSection load='6wru' size='340' side='right'caption='[[6wru]]' scene=''>	+	<StructureSection load='6wru' size='340' side='right'caption='[[6wru]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WRU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wru]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WRU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WRU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wru OCA], [http://pdbe.org/6wru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wru RCSB], [http://www.ebi.ac.uk/pdbsum/6wru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wru ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U7Y:Tedizolid+isomer'>U7Y</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6wqn\|6wqn]], [[6wqq\|6wqq]], [[6wrs\|6wrs]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wru OCA], [http://pdbe.org/6wru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wru RCSB], [http://www.ebi.ac.uk/pdbsum/6wru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wru ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/W8U3W0_STAAU W8U3W0_STAAU]] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01325][RuleBase:RU003906] [[http://www.uniprot.org/uniprot/A0A077UUA0_STAAU A0A077UUA0_STAAU]] Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.[HAMAP-Rule:MF_01367][RuleBase:RU003950] [[http://www.uniprot.org/uniprot/W8TRD5_STAAU W8TRD5_STAAU]] One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.[HAMAP-Rule:MF_01326] One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01326] [[http://www.uniprot.org/uniprot/A0A077W1J0_STAAU A0A077W1J0_STAAU]] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.[HAMAP-Rule:MF_01320] [[http://www.uniprot.org/uniprot/A0A077UGA7_STAAU A0A077UGA7_STAAU]] Binds to the 23S rRNA.[HAMAP-Rule:MF_01341][SAAS:SAAS00687840] [[http://www.uniprot.org/uniprot/A0A077UVB6_STAAU A0A077UVB6_STAAU]] This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.[HAMAP-Rule:MF_00402][RuleBase:RU000559] [[http://www.uniprot.org/uniprot/A0A166DK89_STAAU A0A166DK89_STAAU]] Forms part of the polypeptide exit tunnel.[HAMAP-Rule:MF_01328] One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.[HAMAP-Rule:MF_01328] [[http://www.uniprot.org/uniprot/A0A077V4G0_STAAU A0A077V4G0_STAAU]] Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.[HAMAP-Rule:MF_01342][RuleBase:RU004414] [[http://www.uniprot.org/uniprot/W8TRE0_STAAU W8TRE0_STAAU]] This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.[HAMAP-Rule:MF_01337] [[http://www.uniprot.org/uniprot/W8TUB4_STAAU W8TUB4_STAAU]] One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.[HAMAP-Rule:MF_01369] [[http://www.uniprot.org/uniprot/A0A077VMP6_STAAU A0A077VMP6_STAAU]] Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.[HAMAP-Rule:MF_00382][RuleBase:RU000560] [[http://www.uniprot.org/uniprot/W8TUE6_STAAU W8TUE6_STAAU]] This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.[HAMAP-Rule:MF_01366][RuleBase:RU003878][SAAS:SAAS00725369] [[http://www.uniprot.org/uniprot/A0A0E0VQU6_STAA5 A0A0E0VQU6_STAA5]] This protein binds to 23S rRNA in the presence of protein L20.[HAMAP-Rule:MF_01363][RuleBase:RU000562] [[http://www.uniprot.org/uniprot/W8U3X2_STAAU W8U3X2_STAAU]] This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.[HAMAP-Rule:MF_01365][RuleBase:RU003870] [[http://www.uniprot.org/uniprot/A0A077UKF9_STAAU A0A077UKF9_STAAU]] The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.[HAMAP-Rule:MF_01331] This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.[HAMAP-Rule:MF_01331][RuleBase:RU004008]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Linezolid and tedizolid are oxazolidinones with established clinical utility for the treatment of Gram-positive pathogens. Over time it has become apparent that even modest structural changes to the core phenyl oxazolidinone leads to drastic changes in biological activity. Consequently, the structure-activity relationship around the core oxazolidinone is constantly evolving, often reflected with new structural motifs present in nascent oxazolidinones. Herein we describe the use of cryo-electron microscopy to examine the differences in binding of several functionally different oxazolidinones in the hopes of enhanced understanding of their SAR. Tedizolid, radezolid, T145, and contezolid have been examined within the peptidyl transferase center (PTC) of the 50S ribosomal subunit from methicillin resistant Staphylococcus aureus. The ribosome-antibiotic complexes were resolved to a resolution of around 3 A enabling unambiguous assignment of how each antibiotic interacts with the PTC.
		+
		+	Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM.,Wright A, Deane-Alder K, Marschall E, Bamert R, Venugopal H, Lithgow T, Lupton DW, Belousoff MJ ACS Pharmacol Transl Sci. 2020 May 13;3(3):425-432. doi:, 10.1021/acsptsci.0c00041. eCollection 2020 Jun 12. PMID:32566908<ref>PMID:32566908</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wru" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Belousoff, MJ]]	+	[[Category: Staphylococcus aureus]]
		+	[[Category: Belousoff, M J]]
		+	[[Category: Antibiotic]]
		+	[[Category: Oxazolidinone]]
		+	[[Category: Ribosome]]
		+	[[Category: Tedizolid]]

OCA at 06:29, 3 June 2020

OCA — Wed, 03 Jun 2020 06:29:36 GMT

←Older revision		Revision as of 06:29, 3 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6wru is ON HOLD~~	+	==Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with an isomer of the tedizolid==
-		+	<StructureSection load='6wru' size='340' side='right'caption='[[6wru]]' scene=''>
-	~~Authors: Belousoff, M.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WRU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WRU FirstGlance]. <br>
-	~~Description:~~ Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with an isomer of the tedizolid	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wru OCA], [http://pdbe.org/6wru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wru RCSB], [http://www.ebi.ac.uk/pdbsum/6wru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wru ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Belousoff, ~~M.J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Belousoff, MJ]]

OCA at 04:44, 27 May 2020

OCA — Wed, 27 May 2020 04:44:52 GMT

←Older revision		Revision as of 04:44, 27 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wru is ON HOLD ~~until sometime in the future~~	+	The entry 6wru is ON HOLD

	Authors: Belousoff, M.J.		Authors: Belousoff, M.J.

OCA at 04:04, 13 May 2020

OCA — Wed, 13 May 2020 04:04:44 GMT

←Older revision		Revision as of 04:04, 13 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wru is ON HOLD	+	The entry 6wru is ON HOLD until sometime in the future

	Authors: Belousoff, M.J.		Authors: Belousoff, M.J.

OCA: Protected "6wru" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2020 04:34:56 GMT

Protected "6wru" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:34, 6 May 2020

OCA: New page: '''Unreleased structure''' The entry 6wru is ON HOLD Authors: Belousoff, M.J. Description: Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus...

OCA — Wed, 06 May 2020 04:34:54 GMT

New page: '''Unreleased structure''' The entry 6wru is ON HOLD Authors: Belousoff, M.J. Description: Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus...

New page

'''Unreleased structure'''

The entry 6wru is ON HOLD

Authors: Belousoff, M.J.

Description: Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with an isomer of the tedizolid
[[Category: Unreleased Structures]]
[[Category: Belousoff, M.J]]