6wt8 - Revision history

OCA at 20:50, 28 October 2020

OCA — Wed, 28 Oct 2020 20:50:59 GMT

←Older revision		Revision as of 20:50, 28 October 2020
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	<StructureSection load='6wt8' size='340' side='right'caption='[[6wt8]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='6wt8' size='340' side='right'caption='[[6wt8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6wt8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Flavobacteriaceae_bacterium~~ Flavobacteriaceae ~~bacterium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wt8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Flavobacteriaceae Flavobacteriaceae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT8 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt8 OCA], [http://pdbe.org/6wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt8 OCA], [http://pdbe.org/6wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt8 ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Flavobacteriaceae ~~bacterium~~]]	+	[[Category: Flavobacteriaceae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Govande, A A]]		[[Category: Govande, A A]]

OCA at 10:17, 16 September 2020

OCA — Wed, 16 Sep 2020 10:17:14 GMT

←Older revision		Revision as of 10:17, 16 September 2020
Line 1:		Line 1:

-	==Structure of a STING-associated CdnE c-di-GMP synthase from ~~Flacobacteriaceae~~ sp.==	+	==Structure of a STING-associated CdnE c-di-GMP synthase from Flavobacteriaceae sp.==
-	<StructureSection load='6wt8' size='340' side='right'caption='[[6wt8]]' scene=''>	+	<StructureSection load='6wt8' size='340' side='right'caption='[[6wt8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6wt8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Flavobacteriaceae_bacterium Flavobacteriaceae bacterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt8 OCA], [http://pdbe.org/6wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt8 ProSAT]</span></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt8 OCA], [http://pdbe.org/6wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt8 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides released during bacterial infection and endogenous cyclic GMP-AMP signalling during viral infection and antitumour immunity(1-5). STING shares no structural homology with other known signalling proteins(6-9), limiting functional analysis and preventing explanation of the origin of cyclic dinucleotide signalling in mammalian innate immunity. Here we discover functional STING homologues encoded within prokaryotic defence islands and reveal a conserved mechanism of signal activation. Crystal structures of bacterial STING define a minimal homodimeric scaffold that selectively responds to c-di-GMP synthesized by a neighbouring cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzyme. Bacterial STING domains couple cyclic dinucleotide recognition with protein filament formation to drive TIR effector domain oligomerization and rapid NAD(+) cleavage. We reconstruct the evolutionary events following acquisition of STING into metazoan innate immunity and determine the structure of a full-length TIR-STING fusion from the Pacific oyster Crassostrea gigas. Comparative structural analysis demonstrates how metazoan-specific additions to the core STING scaffold enabled a switch from direct effector function to regulation of antiviral transcription. Together, our results explain the mechanism of STING-dependent signalling and reveal conservation of a functional cGAS-STING pathway in prokaryotic bacteriophage defence.
		+
		+	STING cyclic dinucleotide sensing originated in bacteria.,Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ Nature. 2020 Sep 2. pii: 10.1038/s41586-020-2719-5. doi:, 10.1038/s41586-020-2719-5. PMID:32877915<ref>PMID:32877915</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6wt8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Flavobacteriaceae bacterium]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Govande AA]]	+	[[Category: Govande, A A]]
-	[[Category: Keszei ~~AFA~~]]	+	[[Category: Keszei, A F.A]]
-	[[Category: Kranzusch PJ]]	+	[[Category: Kranzusch, P J]]
-	[[Category: Lowey B]]	+	[[Category: Lowey, B]]
-	[[Category: Millman A]]	+	[[Category: Millman, A]]
-	[[Category: Morehouse BR]]	+	[[Category: Morehouse, B R]]
-	[[Category: Ofir G]]	+	[[Category: Ofir, G]]
-	[[Category: Shao S]]	+	[[Category: Shao, S]]
-	[[Category: Sorek R]]	+	[[Category: Sorek, R]]
		+	[[Category: C-di-gmp]]
		+	[[Category: Cbass]]
		+	[[Category: Cd-ntase]]
		+	[[Category: Sting]]
		+	[[Category: Transferase]]

OCA at 09:34, 9 September 2020

OCA — Wed, 09 Sep 2020 09:34:14 GMT

←Older revision		Revision as of 09:34, 9 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6wt8 is ~~ON HOLD until Paper Publication~~	+	==Structure of a STING-associated CdnE c-di-GMP synthase from Flacobacteriaceae sp.==
-		+	<StructureSection load='6wt8' size='340' side='right'caption='[[6wt8]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt8 OCA], [http://pdbe.org/6wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Govande AA]]
		+	[[Category: Keszei AFA]]
		+	[[Category: Kranzusch PJ]]
		+	[[Category: Lowey B]]
		+	[[Category: Millman A]]
		+	[[Category: Morehouse BR]]
		+	[[Category: Ofir G]]
		+	[[Category: Shao S]]
		+	[[Category: Sorek R]]

OCA at 04:15, 20 May 2020

OCA — Wed, 20 May 2020 04:15:18 GMT

←Older revision		Revision as of 04:15, 20 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6wt8 is ON HOLD	+	The entry 6wt8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6wt8" [edit=sysop:move=sysop]

OCA — Wed, 13 May 2020 04:06:31 GMT

Protected "6wt8" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:06, 13 May 2020

OCA: New page: '''Unreleased structure''' The entry 6wt8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 May 2020 04:06:30 GMT

New page: '''Unreleased structure''' The entry 6wt8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6wt8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]