OCA at 14:41, 18 October 2023

OCA — Wed, 18 Oct 2023 14:41:36 GMT

←Older revision		Revision as of 14:41, 18 October 2023
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	==Hsa Siglec and Unique domains in complex with 6S-sialy-Lewisx==		==Hsa Siglec and Unique domains in complex with 6S-sialy-Lewisx==
-	<StructureSection load='6x3k' size='340' side='right'caption='[[6x3k]]' scene=''>	+	<StructureSection load='6x3k' size='340' side='right'caption='[[6x3k]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X3K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6x3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_gordonii_str._Challis Streptococcus gordonii str. Challis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X3K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x3k OCA], [https://pdbe.org/6x3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x3k RCSB], [https://www.ebi.ac.uk/pdbsum/6x3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x3k ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x3k OCA], [https://pdbe.org/6x3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x3k RCSB], [https://www.ebi.ac.uk/pdbsum/6x3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x3k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HSA_STRGC HSA_STRGC] A cell wall protein involved with PadA in host cell interactions required for colonization and pathogensis (Probable) (PubMed:19884334, PubMed:27616700). Mediates hemagglutination and adherence to ghst glycoproteins (PubMed:11854202). Recognizes fetuin-A (AHSG), a highly glycosylated human plasma protein, also involved in recognition of human platelets, probably via platelet glycoprotein Ib alpha (GP1BA) (PubMed:19884334). Acts in concert with PadA to promote binding to glycosylated human fibronectin (FN1) and vitronectin (VTN), and biofilm formation. Plays a major role in fibronectin and vitronectin binding; binding is mediated by glycosylated regions. Probably mediates interaction of PadA with resting platelets (PubMed:27616700).<ref>PMID:11854202</ref> <ref>PMID:19884334</ref> <ref>PMID:27616700</ref> <ref>PMID:11854202</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial binding to host receptors underlies both commensalism and pathogenesis. Many streptococci adhere to protein-attached carbohydrates expressed on cell surfaces using Siglec-like binding regions (SLBRs). The precise glycan repertoire recognized may dictate whether the organism is a strict commensal versus a pathogen. However, it is currently not clear what drives receptor selectivity. Here, we use five representative SLBRs and identify regions of the receptor binding site that are hypervariable in sequence and structure. We show that these regions control the identity of the preferred carbohydrate ligand using chimeragenesis and single amino acid substitutions. We further evaluate how the identity of the preferred ligand affects the interaction with glycoprotein receptors in human saliva and plasma samples. As point mutations can change the preferred human receptor, these studies suggest how streptococci may adapt to changes in the environmental glycan repertoire.
		+
		+	Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.,Bensing BA, Stubbs HE, Agarwal R, Yamakawa I, Luong K, Solakyildirim K, Yu H, Hadadianpour A, Castro MA, Fialkowski KP, Morrison KM, Wawrzak Z, Chen X, Lebrilla CB, Baudry J, Smith JC, Sullam PM, Iverson TM Nat Commun. 2022 May 18;13(1):2753. doi: 10.1038/s41467-022-30509-y. PMID:35585145<ref>PMID:35585145</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6x3k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Streptococcus gordonii str. Challis]]
	[[Category: Iverson TM]]		[[Category: Iverson TM]]
	[[Category: Stubbs HE]]		[[Category: Stubbs HE]]

OCA at 09:16, 26 May 2021

OCA — Wed, 26 May 2021 09:16:04 GMT

←Older revision		Revision as of 09:16, 26 May 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6x3k ~~is ON HOLD until Paper Publication~~	+	==Hsa Siglec and Unique domains in complex with 6S-sialy-Lewisx==
-		+	<StructureSection load='6x3k' size='340' side='right'caption='[[6x3k]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X3K FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x3k OCA], [https://pdbe.org/6x3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x3k RCSB], [https://www.ebi.ac.uk/pdbsum/6x3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x3k ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Iverson TM]]
		+	[[Category: Stubbs HE]]

OCA at 10:38, 8 July 2020

OCA — Wed, 08 Jul 2020 10:38:47 GMT

←Older revision		Revision as of 10:38, 8 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6x3k is ON HOLD	+	The entry 6x3k is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6x3k" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2020 04:58:35 GMT

Protected "6x3k" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 27 May 2020

OCA: New page: '''Unreleased structure''' The entry 6x3k is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 May 2020 04:58:33 GMT

New page: '''Unreleased structure''' The entry 6x3k is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6x3k is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6x3k - Revision history

OCA at 14:41, 18 October 2023

OCA at 09:16, 26 May 2021

OCA at 10:38, 8 July 2020

OCA: Protected "6x3k" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6x3k is ON HOLD Authors: Description: Category: Unreleased Structures