6xay - Revision history

OCA at 14:49, 18 October 2023

OCA — Wed, 18 Oct 2023 14:49:08 GMT

←Older revision		Revision as of 14:49, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='6xay' size='340' side='right'caption='[[6xay]], [[Resolution\|resolution]] 2.48Å' scene=''>		<StructureSection load='6xay' size='340' side='right'caption='[[6xay]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xay]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xay]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.48Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FN1, FN ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xay OCA], [https://pdbe.org/6xay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xay RCSB], [https://www.ebi.ac.uk/pdbsum/6xay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xay ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xay OCA], [https://pdbe.org/6xay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xay RCSB], [https://www.ebi.ac.uk/pdbsum/6xay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xay ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>	+	[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>	+	[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>

	==See Also==		==See Also==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briknarova, K]]	+	[[Category: Briknarova K]]
-	[[Category: Mou~~, T C~~]]	+	[[Category: Mou TC]]
-	[[Category: Nepomuceno~~, P A~~]]	+	[[Category: Nepomuceno PA]]
-	[[Category: Sprang~~, S R]]~~	+	[[Category: Sprang SR]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Fibronectin]]~~	+
-	~~[[Category: Fn3~~]]	+

OCA at 12:45, 13 October 2021

OCA — Wed, 13 Oct 2021 12:45:33 GMT

←Older revision		Revision as of 12:45, 13 October 2021
Line 12:		Line 12:
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>		[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
		+
		+	==See Also==
		+	*[[Fibronectin 3D structures\|Fibronectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:42, 25 June 2021

OCA — Fri, 25 Jun 2021 07:42:55 GMT

←Older revision		Revision as of 07:42, 25 June 2021
Line 1:		Line 1:

	==Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains==		==Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains==
-	<StructureSection load='6xay' size='340' side='right'caption='[[6xay]]' scene=''>	+	<StructureSection load='6xay' size='340' side='right'caption='[[6xay]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xay]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xay OCA], [https://pdbe.org/6xay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xay RCSB], [https://www.ebi.ac.uk/pdbsum/6xay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xay ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FN1, FN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xay OCA], [https://pdbe.org/6xay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xay RCSB], [https://www.ebi.ac.uk/pdbsum/6xay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xay ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briknarova K]]	+	[[Category: Briknarova, K]]
-	[[Category: Mou TC]]	+	[[Category: Mou, T C]]
-	[[Category: Nepomuceno PA]]	+	[[Category: Nepomuceno, P A]]
-	[[Category: Sprang SR]]	+	[[Category: Sprang, S R]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Fibronectin]]
		+	[[Category: Fn3]]

OCA at 12:09, 9 June 2021

OCA — Wed, 09 Jun 2021 12:09:48 GMT

←Older revision		Revision as of 12:09, 9 June 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6xay is ON HOLD until Jun 05 2022~~	+	==Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains==
-		+	<StructureSection load='6xay' size='340' side='right'caption='[[6xay]]' scene=''>
-	~~Authors: Mou, T.C., Nepomuceno, P.A., Sprang, S.R., Briknarova, K.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAY FirstGlance]. <br>
-	~~Description:~~ Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xay OCA], [https://pdbe.org/6xay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xay RCSB], [https://www.ebi.ac.uk/pdbsum/6xay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xay ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Nepomuceno~~, P.A]]	+	__TOC__
-	[[Category: Briknarova, K]]	+	</StructureSection>
-	[[Category: Mou~~, T.C~~]]	+	[[Category: Large Structures]]
-	[[Category: Sprang~~, S.R~~]]	+	[[Category: Briknarova K]]
		+	[[Category: Mou TC]]
		+	[[Category: Nepomuceno PA]]
		+	[[Category: Sprang SR]]

OCA at 10:45, 8 July 2020

OCA — Wed, 08 Jul 2020 10:45:00 GMT

←Older revision		Revision as of 10:45, 8 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xay is ON HOLD	+	The entry 6xay is ON HOLD until Jun 05 2022

	Authors: Mou, T.C., Nepomuceno, P.A., Sprang, S.R., Briknarova, K.		Authors: Mou, T.C., Nepomuceno, P.A., Sprang, S.R., Briknarova, K.

OCA: Protected "6xay" [edit=sysop:move=sysop]

OCA — Wed, 10 Jun 2020 05:04:40 GMT

Protected "6xay" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 6xay is ON HOLD Authors: Mou, T.C., Nepomuceno, P.A., Sprang, S.R., Briknarova, K. Description: Structure of a fragment of human fibronectin contai...

OCA — Wed, 10 Jun 2020 05:04:39 GMT

New page: '''Unreleased structure''' The entry 6xay is ON HOLD Authors: Mou, T.C., Nepomuceno, P.A., Sprang, S.R., Briknarova, K. Description: Structure of a fragment of human fibronectin contai...

New page

'''Unreleased structure'''

The entry 6xay is ON HOLD

Authors: Mou, T.C., Nepomuceno, P.A., Sprang, S.R., Briknarova, K.

Description: Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains
[[Category: Unreleased Structures]]
[[Category: Nepomuceno, P.A]]
[[Category: Briknarova, K]]
[[Category: Mou, T.C]]
[[Category: Sprang, S.R]]