6xec - Revision history

OCA at 14:49, 6 March 2024

OCA — Wed, 06 Mar 2024 14:49:27 GMT

←Older revision		Revision as of 14:49, 6 March 2024
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	==STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O)==		==STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O)==
-	<StructureSection load='6xec' size='340' side='right'caption='[[6xec]]' scene=''>	+	<StructureSection load='6xec' size='340' side='right'caption='[[6xec]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XEC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6XEC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xec]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XEC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xec OCA], [~~http~~://pdbe.org/6xec PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6xec RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6xec PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6xec ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.701Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V1S:(1S)-N-{(1S)-1-[5-cyano-2-(4-fluorophenyl)-1H-imidazol-4-yl]-7,7-dihydroxynonyl}-6-methyl-6-azaspiro[2.5]octane-1-carboxamide'>V1S</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xec OCA], [https://pdbe.org/6xec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xec RCSB], [https://www.ebi.ac.uk/pdbsum/6xec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xec ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HDAC2_HUMAN HDAC2_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:19343227</ref>
		+
		+	==See Also==
		+	*[[Histone deacetylase 3D structures\|Histone deacetylase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Clausen D]]		[[Category: Clausen D]]
	[[Category: Klein DJ]]		[[Category: Klein DJ]]

OCA at 09:48, 12 August 2020

OCA — Wed, 12 Aug 2020 09:48:57 GMT

←Older revision		Revision as of 09:48, 12 August 2020
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-	'''Unreleased structure'''

-	~~The entry 6xec is ON HOLD until Paper Publication~~	+	==STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O)==
-		+	<StructureSection load='6xec' size='340' side='right'caption='[[6xec]]' scene=''>
-	~~Authors: Klein, D.J., Clausen, D.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XEC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XEC FirstGlance]. <br>
-	~~Description:~~ STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xec OCA], [http://pdbe.org/6xec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xec RCSB], [http://www.ebi.ac.uk/pdbsum/6xec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xec ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Clausen, D]]	+	__TOC__
-	[[Category: Klein~~, D.J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Clausen D]]
		+	[[Category: Klein DJ]]

OCA at 06:37, 22 July 2020

OCA — Wed, 22 Jul 2020 06:37:46 GMT

←Older revision		Revision as of 06:37, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xec is ON HOLD	+	The entry 6xec is ON HOLD until Paper Publication

	Authors: Klein, D.J., Clausen, D.		Authors: Klein, D.J., Clausen, D.
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	Description: STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O)		Description: STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Klein, D.J]]
	[[Category: Clausen, D]]		[[Category: Clausen, D]]
		+	[[Category: Klein, D.J]]

OCA: Protected "6xec" [edit=sysop:move=sysop]

OCA — Wed, 24 Jun 2020 18:25:35 GMT

Protected "6xec" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:25, 24 June 2020

OCA: New page: '''Unreleased structure''' The entry 6xec is ON HOLD Authors: Klein, D.J., Clausen, D. Description: STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O) [[Category: U...

OCA — Wed, 24 Jun 2020 18:25:34 GMT

New page: '''Unreleased structure''' The entry 6xec is ON HOLD Authors: Klein, D.J., Clausen, D. Description: STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O) [[Category: U...

New page

'''Unreleased structure'''

The entry 6xec is ON HOLD

Authors: Klein, D.J., Clausen, D.

Description: STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND O)
[[Category: Unreleased Structures]]
[[Category: Klein, D.J]]
[[Category: Clausen, D]]