6xhr - Revision history

OCA at 14:52, 18 October 2023

OCA — Wed, 18 Oct 2023 14:52:40 GMT

←Older revision		Revision as of 14:52, 18 October 2023
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	<StructureSection load='6xhr' size='340' side='right'caption='[[6xhr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6xhr' size='340' side='right'caption='[[6xhr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xhr]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XHR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xhr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XHR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>[https://en.wikipedia.org/wiki/D-ribitol-5-phosphate_cytidylyltransferase D-ribitol-5-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.40 2.7.7.40] </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xhr OCA], [https://pdbe.org/6xhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xhr RCSB], [https://www.ebi.ac.uk/pdbsum/6xhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xhr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xhr OCA], [https://pdbe.org/6xhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xhr RCSB], [https://www.ebi.ac.uk/pdbsum/6xhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xhr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TARI1_STAA8 TARI1_STAA8]] Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.[HAMAP-Rule:MF_02068]<ref>PMID:15362865</ref>	+	[https://www.uniprot.org/uniprot/TARI1_STAA8 TARI1_STAA8] Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.[HAMAP-Rule:MF_02068]<ref>PMID:15362865</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: D-ribitol-5-phosphate cytidylyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Li, F K.K~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Strynadka, N C.J~~]]	+	[[Category: Li FKK]]
-	[[Category: ~~Cytidylyltransferase]]~~	+	[[Category: Strynadka NCJ]]
-	~~[[Category: Transferase~~]]	+

OCA at 05:28, 28 April 2021

OCA — Wed, 28 Apr 2021 05:28:30 GMT

←Older revision		Revision as of 05:28, 28 April 2021
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	==Crystal structure of S. aureus TarI (space group P1211)==		==Crystal structure of S. aureus TarI (space group P1211)==
-	<StructureSection load='6xhr' size='340' side='right'caption='[[6xhr]]' scene=''>	+	<StructureSection load='6xhr' size='340' side='right'caption='[[6xhr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XHR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xhr]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XHR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xhr OCA], [https://pdbe.org/6xhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xhr RCSB], [https://www.ebi.ac.uk/pdbsum/6xhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xhr ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-ribitol-5-phosphate_cytidylyltransferase D-ribitol-5-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.40 2.7.7.40] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xhr OCA], [https://pdbe.org/6xhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xhr RCSB], [https://www.ebi.ac.uk/pdbsum/6xhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xhr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TARI1_STAA8 TARI1_STAA8]] Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.[HAMAP-Rule:MF_02068]<ref>PMID:15362865</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cell wall of many pathogenic Gram-positive bacteria contains ribitol-phosphate wall teichoic acid (WTA), a polymer that is linked to virulence and regulation of essential physiological processes including cell division. CDP-ribitol, the activated precursor for ribitol-phosphate polymerization, is synthesized by a cytidylyltransferase and reductase pair known as TarI and TarJ, respectively. In this study, we present crystal structures of Staphylococcus aureus TarI and TarJ in their apo forms and in complex with substrates and products. The TarI structures illustrate the mechanism of CDP-ribitol synthesis from CTP and ribitol-phosphate and reveal structural changes required for substrate binding and catalysis. Insights into the upstream step of ribulose-phosphate reduction to ribitol-phosphate is provided by the structures of TarJ. Furthermore, we propose a general topology of the enzymes in a heterotetrameric form built using restraints from crosslinking mass spectrometry analysis. Together, our data present molecular details of CDP-ribitol production that may aid in the design of inhibitors against WTA biosynthesis.
		+
		+	Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis.,Li FKK, Gale RT, Petrotchenko EV, Borchers CH, Brown ED, Strynadka NCJ J Struct Biol. 2021 Apr 2:107733. doi: 10.1016/j.jsb.2021.107733. PMID:33819634<ref>PMID:33819634</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xhr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: D-ribitol-5-phosphate cytidylyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li ~~FKK~~]]	+	[[Category: Li, F K.K]]
-	[[Category: Strynadka ~~NCJ~~]]	+	[[Category: Strynadka, N C.J]]
		+	[[Category: Cytidylyltransferase]]
		+	[[Category: Transferase]]

OCA at 08:20, 21 April 2021

OCA — Wed, 21 Apr 2021 08:20:23 GMT

←Older revision		Revision as of 08:20, 21 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6xhr ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of S. aureus TarI (space group P1211)==
-		+	<StructureSection load='6xhr' size='340' side='right'caption='[[6xhr]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XHR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xhr OCA], [https://pdbe.org/6xhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xhr RCSB], [https://www.ebi.ac.uk/pdbsum/6xhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xhr ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li FKK]]
		+	[[Category: Strynadka NCJ]]

OCA at 06:41, 22 July 2020

OCA — Wed, 22 Jul 2020 06:41:33 GMT

←Older revision		Revision as of 06:41, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xhr is ON HOLD	+	The entry 6xhr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6xhr" [edit=sysop:move=sysop]

OCA — Wed, 24 Jun 2020 18:33:53 GMT

Protected "6xhr" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:33, 24 June 2020

OCA: New page: '''Unreleased structure''' The entry 6xhr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Jun 2020 18:33:52 GMT

New page: '''Unreleased structure''' The entry 6xhr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6xhr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]