6xjj - Revision history

OCA at 14:53, 18 October 2023

OCA — Wed, 18 Oct 2023 14:53:29 GMT

←Older revision		Revision as of 14:53, 18 October 2023
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	==Structure of non-heme iron enzyme TropC: Radical tropolone biosynthesis==		==Structure of non-heme iron enzyme TropC: Radical tropolone biosynthesis==
-	<StructureSection load='6xjj' size='340' side='right'caption='[[6xjj]]' scene=''>	+	<StructureSection load='6xjj' size='340' side='right'caption='[[6xjj]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XJJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xjj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Talaromyces_stipitatus_ATCC_10500 Talaromyces stipitatus ATCC 10500]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XJJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjj OCA], [https://pdbe.org/6xjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xjj RCSB], [https://www.ebi.ac.uk/pdbsum/6xjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjj OCA], [https://pdbe.org/6xjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xjj RCSB], [https://www.ebi.ac.uk/pdbsum/6xjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TROPC_TALSN TROPC_TALSN] 2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of the tropolone class of fungal maleic anhydrides (PubMed:22508998, PubMed:24863423). The pathway begins with the synthesis of 3-methylorcinaldehyde by the non-reducing polyketide synthase (PKS) tropA (PubMed:22508998). 3-methylorcinaldehyde is the substrate for the FAD-dependent monooxygenase tropB to yield a dearomatized hydroxycyclohexadione (PubMed:22508998, PubMed:24863423). The 2-oxoglutarate-dependent dioxygenase tropC then performs the oxidative ring expansion to provide the first tropolone metabolite stipitaldehyde (PubMed:22508998, PubMed:24863423). Trop D converts stipitaldehyde into stipitacetal which is in turn converted to stipitalide by the short-chain dehydrogenase/reductase tropE (PubMed:24863423). The next steps involve tropF, tropG, tropH, tropI and tropJ to form successive tropolone maleic anhydrides including stipitaldehydic, stipitatonic and stipitatic acids (PubMed:24863423).<ref>PMID:22508998</ref> <ref>PMID:24863423</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Talaromyces stipitatus ATCC 10500]]
	[[Category: Doyon TJ]]		[[Category: Doyon TJ]]
	[[Category: Koutmos M]]		[[Category: Koutmos M]]
	[[Category: Mallik L]]		[[Category: Mallik L]]
	[[Category: Narayan ARH]]		[[Category: Narayan ARH]]

OCA at 14:33, 2 June 2021

OCA — Wed, 02 Jun 2021 14:33:06 GMT

←Older revision		Revision as of 14:33, 2 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6xjj is ~~ON HOLD until Paper Publication~~	+	==Structure of non-heme iron enzyme TropC: Radical tropolone biosynthesis==
-		+	<StructureSection load='6xjj' size='340' side='right'caption='[[6xjj]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XJJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjj OCA], [https://pdbe.org/6xjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xjj RCSB], [https://www.ebi.ac.uk/pdbsum/6xjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Doyon TJ]]
		+	[[Category: Koutmos M]]
		+	[[Category: Mallik L]]
		+	[[Category: Narayan ARH]]

OCA at 09:23, 29 July 2020

OCA — Wed, 29 Jul 2020 09:23:20 GMT

←Older revision		Revision as of 09:23, 29 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xjj is ON HOLD	+	The entry 6xjj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6xjj" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 10:52:04 GMT

Protected "6xjj" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:52, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6xjj is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 10:52:03 GMT

New page: '''Unreleased structure''' The entry 6xjj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6xjj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]