6xk0 - Revision history

OCA at 14:53, 18 October 2023

OCA — Wed, 18 Oct 2023 14:53:56 GMT

←Older revision		Revision as of 14:53, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='6xk0' size='340' side='right'caption='[[6xk0]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6xk0' size='340' side='right'caption='[[6xk0]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xk0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XK0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6XK0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XK0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX~~</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX~~</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6xk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xk0 OCA], [~~http~~://pdbe.org/6xk0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6xk0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6xk0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6xk0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xk0 OCA], [https://pdbe.org/6xk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xk0 RCSB], [https://www.ebi.ac.uk/pdbsum/6xk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xk0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ALBU_HORSE ALBU_HORSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6xk0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6xk0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 28:
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Czub~~, M P~~]]	+	[[Category: Czub MP]]
-	[[Category: Majorek~~, K A~~]]	+	[[Category: Majorek KA]]
-	[[Category: Minor, W]]	+	[[Category: Minor W]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shabalin IG]]
-	[[Category: Shabalin~~, I G]]~~	+
-	~~[[Category: Drug transport]]~~	+
-	~~[[Category: Esa]]~~	+
-	~~[[Category: Nysgrc]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:12, 25 November 2020

OCA — Wed, 25 Nov 2020 07:12:37 GMT

←Older revision		Revision as of 07:12, 25 November 2020
Line 1:		Line 1:

	==Albumin-dexamethasone complex==		==Albumin-dexamethasone complex==
-	<StructureSection load='6xk0' size='340' side='right'caption='[[6xk0]]' scene=''>	+	<StructureSection load='6xk0' size='340' side='right'caption='[[6xk0]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XK0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XK0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xk0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XK0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XK0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xk0 OCA], [http://pdbe.org/6xk0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xk0 RCSB], [http://www.ebi.ac.uk/pdbsum/6xk0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xk0 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xk0 OCA], [http://pdbe.org/6xk0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xk0 RCSB], [http://www.ebi.ac.uk/pdbsum/6xk0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xk0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by binding to serum albumin. Here, the first structure of serum albumin in complex with dexamethasone is reported. Dexamethasone binds to drug site 7, which is also the binding site for commonly used nonsteroidal anti-inflammatory drugs and testosterone, suggesting potentially problematic binding competition. This study bridges structural findings with an analysis of publicly available clinical data from Wuhan and suggests that an adjustment of the dexamethasone regimen should be further investigated as a strategy for patients affected by two major COVID-19 risk factors: low albumin levels and diabetes.
		+
		+	Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy.,Shabalin IG, Czub MP, Majorek KA, Brzezinski D, Grabowski M, Cooper DR, Panasiuk M, Chruszcz M, Minor W IUCrJ. 2020 Sep 29;7(Pt 6). pii: S2052252520012944. doi:, 10.1107/S2052252520012944. PMID:33063792<ref>PMID:33063792</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xk0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Czub MP]]	+	[[Category: Czub, M P]]
-	[[Category: Majorek KA]]	+	[[Category: Majorek, K A]]
-	[[Category: Minor W]]	+	[[Category: Minor, W]]
-	[[Category: Shabalin IG]]	+	[[Category: Structural genomic]]
		+	[[Category: Shabalin, I G]]
		+	[[Category: Drug transport]]
		+	[[Category: Esa]]
		+	[[Category: Nysgrc]]
		+	[[Category: Psi-biology]]
		+	[[Category: Transport protein]]

OCA at 05:59, 5 August 2020

OCA — Wed, 05 Aug 2020 05:59:39 GMT

←Older revision		Revision as of 05:59, 5 August 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6xk0 ~~is ON HOLD~~	+	==Albumin-dexamethasone complex==
-		+	<StructureSection load='6xk0' size='340' side='right'caption='[[6xk0]]' scene=''>
-	~~Authors~~: ~~Czub, M~~.P.~~, Majorek, K~~.A.~~, Shabalin, I~~.G.~~, Minor, W~~.~~, Center for Structural Genomics of Infectious Diseases (CSGID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XK0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XK0 FirstGlance]. <br>
-	~~Description~~: ~~Albumin-dexamethasone complex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xk0 OCA], [http://pdbe.org/6xk0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xk0 RCSB], [http://www.ebi.ac.uk/pdbsum/6xk0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xk0 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Shabalin~~, I.G]]	+	__TOC__
-	[[Category: ~~Majorek, K.A~~]]	+	</StructureSection>
-	[[Category: Czub~~, M.P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Center For Structural Genomics Of Infectious Diseases (Csgid)~~]]	+	[[Category: Czub MP]]
-	[[Category: Minor, W]]	+	[[Category: Majorek KA]]
		+	[[Category: Minor W]]
		+	[[Category: Shabalin IG]]

OCA: Protected "6xk0" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 10:53:11 GMT

Protected "6xk0" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:53, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6xk0 is ON HOLD Authors: Czub, M.P., Majorek, K.A., Shabalin, I.G., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID) Descri...

OCA — Wed, 08 Jul 2020 10:53:10 GMT

New page: '''Unreleased structure''' The entry 6xk0 is ON HOLD Authors: Czub, M.P., Majorek, K.A., Shabalin, I.G., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID) Descri...

New page

'''Unreleased structure'''

The entry 6xk0 is ON HOLD

Authors: Czub, M.P., Majorek, K.A., Shabalin, I.G., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: Albumin-dexamethasone complex
[[Category: Unreleased Structures]]
[[Category: Shabalin, I.G]]
[[Category: Majorek, K.A]]
[[Category: Czub, M.P]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
[[Category: Minor, W]]