6xrx - Revision history

OCA at 14:59, 18 October 2023

OCA — Wed, 18 Oct 2023 14:59:52 GMT

←Older revision		Revision as of 14:59, 18 October 2023
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	==Crystal structure of the mosquito protein AZ1 as an MBP fusion==		==Crystal structure of the mosquito protein AZ1 as an MBP fusion==
-	<StructureSection load='6xrx' size='340' side='right'caption='[[6xrx]]' scene=''>	+	<StructureSection load='6xrx' size='340' side='right'caption='[[6xrx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XRX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xrx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XRX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xrx OCA], [https://pdbe.org/6xrx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xrx RCSB], [https://www.ebi.ac.uk/pdbsum/6xrx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xrx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xrx OCA], [https://pdbe.org/6xrx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xrx RCSB], [https://www.ebi.ac.uk/pdbsum/6xrx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xrx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/Q8T5C5_AEDAE Q8T5C5_AEDAE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mosquito protein AEG12 is up-regulated in response to blood meals and flavivirus infection though its function remained elusive. Here, we determine the three-dimensional structure of AEG12 and describe the binding specificity of acyl-chain ligands within its large central hydrophobic cavity. We show that AEG12 displays hemolytic and cytolytic activity by selectively delivering unsaturated fatty acid cargoes into phosphatidylcholine-rich lipid bilayers. This property of AEG12 also enables it to inhibit replication of enveloped viruses such as Dengue and Zika viruses at low micromolar concentrations. Weaker inhibition was observed against more distantly related coronaviruses and lentivirus, while no inhibition was observed against the nonenveloped virus adeno-associated virus. Together, our results uncover the mechanistic understanding of AEG12 function and provide the necessary implications for its use as a broad-spectrum therapeutic against cellular and viral targets.
		+
		+	The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.,Foo ACY, Thompson PM, Chen SH, Jadi R, Lupo B, DeRose EF, Arora S, Placentra VC, Premkumar L, Perera L, Pedersen LC, Martin N, Mueller GA Proc Natl Acad Sci U S A. 2021 Mar 16;118(11). pii: 2019251118. doi:, 10.1073/pnas.2019251118. PMID:33688047<ref>PMID:33688047</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xrx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aedes aegypti]]
		+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Foo ACY]]		[[Category: Foo ACY]]
	[[Category: Mueller GA]]		[[Category: Mueller GA]]
	[[Category: Pedersen LC]]		[[Category: Pedersen LC]]

OCA at 06:38, 24 March 2021

OCA — Wed, 24 Mar 2021 06:38:21 GMT

←Older revision		Revision as of 06:38, 24 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6xrx ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the mosquito protein AZ1 as an MBP fusion==
-		+	<StructureSection load='6xrx' size='340' side='right'caption='[[6xrx]]' scene=''>
-	~~Authors~~: ~~Pedersen~~, L.C., ~~Mueller~~, G.A., ~~Foo, A~~.C.Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XRX FirstGlance]. <br>
-	~~Description: Crystal structure of the mosquito protein AZ1 as an MBP fusion~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xrx OCA], [https://pdbe.org/6xrx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xrx RCSB], [https://www.ebi.ac.uk/pdbsum/6xrx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xrx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Pedersen, L.C~~]]	+	__TOC__
-	[[Category: Mueller~~, G.A~~]]	+	</StructureSection>
-	[[Category: ~~Foo, A.C.Y~~]]	+	[[Category: Large Structures]]
		+	[[Category: Foo ACY]]
		+	[[Category: Mueller GA]]
		+	[[Category: Pedersen LC]]

OCA at 09:06, 26 August 2020

OCA — Wed, 26 Aug 2020 09:06:33 GMT

←Older revision		Revision as of 09:06, 26 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xrx is ON HOLD	+	The entry 6xrx is ON HOLD until Paper Publication

	Authors: Pedersen, L.C., Mueller, G.A., Foo, A.C.Y.		Authors: Pedersen, L.C., Mueller, G.A., Foo, A.C.Y.

OCA: Protected "6xrx" [edit=sysop:move=sysop]

OCA — Wed, 22 Jul 2020 06:58:04 GMT

Protected "6xrx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 22 July 2020

OCA: New page: '''Unreleased structure''' The entry 6xrx is ON HOLD Authors: Pedersen, L.C., Mueller, G.A., Foo, A.C.Y. Description: Crystal structure of the mosquito protein AZ1 as an MBP fusion [[C...

OCA — Wed, 22 Jul 2020 06:58:03 GMT

New page: '''Unreleased structure''' The entry 6xrx is ON HOLD Authors: Pedersen, L.C., Mueller, G.A., Foo, A.C.Y. Description: Crystal structure of the mosquito protein AZ1 as an MBP fusion [[C...

New page

'''Unreleased structure'''

The entry 6xrx is ON HOLD

Authors: Pedersen, L.C., Mueller, G.A., Foo, A.C.Y.

Description: Crystal structure of the mosquito protein AZ1 as an MBP fusion
[[Category: Unreleased Structures]]
[[Category: Pedersen, L.C]]
[[Category: Mueller, G.A]]
[[Category: Foo, A.C.Y]]