6xsw - Revision history

OCA at 09:16, 25 October 2023

OCA — Wed, 25 Oct 2023 09:16:57 GMT

←Older revision		Revision as of 09:16, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6xsw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XSW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6xsw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XSW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xsw OCA], [https://pdbe.org/6xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xsw RCSB], [https://www.ebi.ac.uk/pdbsum/6xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xsw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xsw OCA], [https://pdbe.org/6xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xsw RCSB], [https://www.ebi.ac.uk/pdbsum/6xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xsw ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:03, 1 February 2023

OCA — Wed, 01 Feb 2023 12:03:35 GMT

←Older revision		Revision as of 12:03, 1 February 2023
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-	====	+	==Structure of the Notch3 NRR in complex with an antibody Fab Fragment==
-	<StructureSection load='6xsw' size='340' side='right'caption='[[6xsw]]' scene=''>	+	<StructureSection load='6xsw' size='340' side='right'caption='[[6xsw]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xsw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XSW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xsw OCA], [https://pdbe.org/6xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xsw RCSB], [https://www.ebi.ac.uk/pdbsum/6xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xsw ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xsw OCA], [https://pdbe.org/6xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xsw RCSB], [https://www.ebi.ac.uk/pdbsum/6xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xsw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/NOTC3_HUMAN NOTC3_HUMAN] CADASIL;Infantile myofibromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NOTC3_HUMAN NOTC3_HUMAN] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation of an auristatin microtubule inhibitor through a protease cleavable linker to two antibodies with differential abilities to inhibit signaling. The signaling inhibitory antibody rapidly induces ligand-independent receptor clustering and internalization through both caveolin and clathrin-mediated pathways. The non-inhibitory antibody also efficiently endocytoses via clathrin without inducing receptor clustering but with slower lysosomal co-localization kinetics. In addition, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. NOTCH3-ADCs internalize into receptor and ligand cells independent of signaling and induce cell death in both cell types representing an atypical mechanism of ADC cytotoxicity. Treatment of xenografts with NOTCH3-ADCs leads to sustained tumor regressions, outperforms standard-of-care chemotherapy, and allows targeting of tumors that overexpress NOTCH3 independent of signaling inhibition.
		+
		+	NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.,Geles KG, Gao Y, Giannakou A, Sridharan L, Yamin TT, Zhang J, Karim R, Bard J, Piche-Nicholas N, Charati M, Maderna A, Lucas J, Golas J, Guffroy M, Pirie-Shepherd S, Roy M, Qian J, Franks T, Zhong W, O'Donnell CJ, Tchistiakova L, Gerber HP, Sapra P Cell Rep Med. 2021 May 18;2(5):100279. doi: 10.1016/j.xcrm.2021.100279. , eCollection 2021 May 18. PMID:34095881<ref>PMID:34095881</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xsw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Rattus norvegicus]]
		+	[[Category: Bard J]]

OCA at 08:55, 21 July 2021

OCA — Wed, 21 Jul 2021 08:55:40 GMT

←Older revision		Revision as of 08:55, 21 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6xsw ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6xsw' size='340' side='right'caption='[[6xsw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xsw OCA], [https://pdbe.org/6xsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xsw RCSB], [https://www.ebi.ac.uk/pdbsum/6xsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xsw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:26, 29 July 2020

OCA — Wed, 29 Jul 2020 09:26:11 GMT

←Older revision		Revision as of 09:26, 29 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xsw is ON HOLD	+	The entry 6xsw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6xsw" [edit=sysop:move=sysop]

OCA — Wed, 22 Jul 2020 07:02:13 GMT

Protected "6xsw" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:02, 22 July 2020

OCA: New page: '''Unreleased structure''' The entry 6xsw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Jul 2020 07:02:11 GMT

New page: '''Unreleased structure''' The entry 6xsw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6xsw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]