6xtj - Revision history

OCA at 13:12, 24 January 2024

OCA — Wed, 24 Jan 2024 13:12:18 GMT

←Older revision		Revision as of 13:12, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6xtj' size='340' side='right'caption='[[6xtj]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6xtj' size='340' side='right'caption='[[6xtj]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xtj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XTJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6XTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xtj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XTJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6xtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xtj OCA], [~~http~~://pdbe.org/6xtj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6xtj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6xtj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6xtj ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xtj OCA], [https://pdbe.org/6xtj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xtj RCSB], [https://www.ebi.ac.uk/pdbsum/6xtj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xtj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FERM2_HUMAN FERM2_HUMAN]] Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<ref>PMID:12679033</ref> <ref>PMID:18458155</ref> <ref>PMID:21325030</ref> <ref>PMID:22699938</ref> <ref>PMID:22030399</ref> <ref>PMID:22078565</ref>	+	[https://www.uniprot.org/uniprot/FERM2_HUMAN FERM2_HUMAN] Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<ref>PMID:12679033</ref> <ref>PMID:18458155</ref> <ref>PMID:21325030</ref> <ref>PMID:22699938</ref> <ref>PMID:22030399</ref> <ref>PMID:22078565</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Bradshaw~~, W J]]~~	+	[[Category: Bradshaw WJ]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Gileadi O]]
-	[[Category: Gileadi, O]]	+	[[Category: Katis VL]]
-	[[Category: Katis~~, V L~~]]	+	[[Category: Newman JA]]
-	[[Category: Newman~~, J A~~]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Alzheimer's disease]]~~	+
-	~~[[Category: Ferm domain]]~~	+
-	~~[[Category: Integrin binding]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 04:31, 13 February 2020

OCA — Thu, 13 Feb 2020 04:31:34 GMT

←Older revision		Revision as of 04:31, 13 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6xtj is ~~ON HOLD~~	+	==The high resolution structure of the FERM domain of human FERMT2==
-		+	<StructureSection load='6xtj' size='340' side='right'caption='[[6xtj]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Bradshaw, W~~.J.~~, Katis, V~~.L., ~~Newman, J~~.A., ~~von Delft, F~~., ~~Arrowsmith, C~~.H.~~, Edwards, A~~., ~~Bountra, C~~., ~~Gileadi, O~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6xtj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6XTJ FirstGlance]. <br>
-	~~Description~~: ~~The high resolution structure~~ of the ~~FERM domain~~ of ~~human FERMT2~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6xtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xtj OCA], [http://pdbe.org/6xtj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xtj RCSB], [http://www.ebi.ac.uk/pdbsum/6xtj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xtj ProSAT]</span></td></tr>
-	[[Category: ~~Katis~~, ~~V.L~~]]	+	</table>
-	[[Category: ~~Arrowsmith~~, C.H]]	+	== Function ==
-	[[Category: Bradshaw, W.J]]	+	[[http://www.uniprot.org/uniprot/FERM2_HUMAN FERM2_HUMAN]] Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<ref>PMID:12679033</ref> <ref>PMID:18458155</ref> <ref>PMID:21325030</ref> <ref>PMID:22699938</ref> <ref>PMID:22030399</ref> <ref>PMID:22078565</ref>
-	[[Category: ~~Von~~ Delft, F]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Bradshaw, W J]]
		+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A]]
	[[Category: Gileadi, O]]		[[Category: Gileadi, O]]
-	[[Category: Newman, J.A]]	+	[[Category: Katis, V L]]
-	[[Category: ~~Edwards, A~~]]	+	[[Category: Newman, J A]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Alzheimer's disease]]
		+	[[Category: Ferm domain]]
		+	[[Category: Integrin binding]]
		+	[[Category: Protein binding]]

OCA: Protected "6xtj" [edit=sysop:move=sysop]

OCA — Wed, 22 Jan 2020 14:37:40 GMT

Protected "6xtj" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:37, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6xtj is ON HOLD Authors: Bradshaw, W.J., Katis, V.L., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O. Descript...

OCA — Wed, 22 Jan 2020 14:37:38 GMT

New page: '''Unreleased structure''' The entry 6xtj is ON HOLD Authors: Bradshaw, W.J., Katis, V.L., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O. Descript...

New page

'''Unreleased structure'''

The entry 6xtj is ON HOLD

Authors: Bradshaw, W.J., Katis, V.L., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

Description: The high resolution structure of the FERM domain of human FERMT2
[[Category: Unreleased Structures]]
[[Category: Katis, V.L]]
[[Category: Arrowsmith, C.H]]
[[Category: Bradshaw, W.J]]
[[Category: Von Delft, F]]
[[Category: Gileadi, O]]
[[Category: Newman, J.A]]
[[Category: Edwards, A]]
[[Category: Bountra, C]]