6xwx - Revision history

OCA at 13:14, 24 January 2024

OCA — Wed, 24 Jan 2024 13:14:24 GMT

←Older revision		Revision as of 13:14, 24 January 2024
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	<StructureSection load='6xwx' size='340' side='right'caption='[[6xwx]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6xwx' size='340' side='right'caption='[[6xwx]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xwx]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chatd Chatd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XWX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6XWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xwx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XWX FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CTHT_0029130 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~759272 CHATD])~~, ~~CTHT_0011090 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=759272 CHATD])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6xwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xwx OCA], [~~http~~://pdbe.org/6xwx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6xwx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6xwx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6xwx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xwx OCA], [https://pdbe.org/6xwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xwx RCSB], [https://www.ebi.ac.uk/pdbsum/6xwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xwx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~G0S0S7_CHATD G0S0S7_CHATD]] Plays an important role in the control of DNA replication and the maintenance of replication fork stability.[RuleBase:RU366049~~]	+	[https://www.uniprot.org/uniprot/G0S825_CHATD G0S825_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chatd~~]]	+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Grabarczyk~~, D B]]~~	+	[[Category: Grabarczyk DB]]
-	~~[[Category: Armadillo repeat]]~~	+
-	~~[[Category: Cohesion establishment]]~~	+
-	~~[[Category: Fork protection complex]]~~	+
-	~~[[Category: Replication]]~~	+
-	~~[[Category: Replisome]]~~	+
-	~~[[Category: S phase checkpoint~~]]	+

OCA at 06:51, 10 June 2020

OCA — Wed, 10 Jun 2020 06:51:49 GMT

←Older revision		Revision as of 06:51, 10 June 2020
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	==Crystal structure of the Tof1-Csm3 complex==		==Crystal structure of the Tof1-Csm3 complex==
-	<StructureSection load='6xwx' size='340' side='right'caption='[[6xwx]]' scene=''>	+	<StructureSection load='6xwx' size='340' side='right'caption='[[6xwx]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XWX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xwx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XWX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XWX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xwx OCA], [http://pdbe.org/6xwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xwx RCSB], [http://www.ebi.ac.uk/pdbsum/6xwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xwx ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0029130 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), CTHT_0011090 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xwx OCA], [http://pdbe.org/6xwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xwx RCSB], [http://www.ebi.ac.uk/pdbsum/6xwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xwx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G0S0S7_CHATD G0S0S7_CHATD]] Plays an important role in the control of DNA replication and the maintenance of replication fork stability.[RuleBase:RU366049]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Tof1-Csm3 fork protection complex has a central role in the replisome-it promotes the progression of DNA replication forks and protects them when they stall, while also enabling cohesion establishment and checkpoint responses. Here, I present the crystal structure of the Tof1-Csm3 complex from Chaetomium thermophilum at 3.1 A resolution. The structure reveals that both proteins together form an extended alpha helical repeat structure, which suggests a mechanical or scaffolding role for the complex. Expanding on this idea, I characterize a DNA interacting region and a cancer-associated Mrc1 binding site. This study provides the molecular basis for understanding the functions of the Tof1-Csm3 complex, its human orthologue the Timeless-Tipin complex and additionally the Drosophila circadian rhythm protein Timeless.
		+
		+	Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.,Grabarczyk DB Nucleic Acids Res. 2020 May 29. pii: 5848492. doi: 10.1093/nar/gkaa456. PMID:32469068<ref>PMID:32469068</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xwx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chatd]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Grabarczyk DB]]	+	[[Category: Grabarczyk, D B]]
		+	[[Category: Armadillo repeat]]
		+	[[Category: Cohesion establishment]]
		+	[[Category: Fork protection complex]]
		+	[[Category: Replication]]
		+	[[Category: Replisome]]
		+	[[Category: S phase checkpoint]]

OCA at 07:05, 27 May 2020

OCA — Wed, 27 May 2020 07:05:23 GMT

←Older revision		Revision as of 07:05, 27 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6xwx ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the Tof1-Csm3 complex==
-		+	<StructureSection load='6xwx' size='340' side='right'caption='[[6xwx]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XWX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XWX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xwx OCA], [http://pdbe.org/6xwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xwx RCSB], [http://www.ebi.ac.uk/pdbsum/6xwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xwx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Grabarczyk DB]]

OCA: Protected "6xwx" [edit=sysop:move=sysop]

OCA — Wed, 05 Feb 2020 06:26:40 GMT

Protected "6xwx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:26, 5 February 2020

OCA: New page: '''Unreleased structure''' The entry 6xwx is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Feb 2020 06:26:38 GMT

New page: '''Unreleased structure''' The entry 6xwx is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6xwx is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]