6xxp - Revision history

OCA at 13:15, 24 January 2024

OCA — Wed, 24 Jan 2024 13:15:00 GMT

←Older revision		Revision as of 13:15, 24 January 2024
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	<StructureSection load='6xxp' size='340' side='right'caption='[[6xxp]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='6xxp' size='340' side='right'caption='[[6xxp]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6xxp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arabian_camel Arabian camel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6XXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XXP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6xxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxp OCA], [~~http~~://pdbe.org/6xxp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6xxp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6xxp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxp ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxp OCA], [https://pdbe.org/6xxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xxp RCSB], [https://www.ebi.ac.uk/pdbsum/6xxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabian camel~~]]	+	[[Category: Camelus dromedarius]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Papo, N]]	+	[[Category: Papo N]]
-	[[Category: Rosenfeld, L]]	+	[[Category: Rosenfeld L]]
-	[[Category: Shahar, A]]	+	[[Category: Shahar A]]
-	~~[[Category: Anti-cancer drugs]]~~	+
-	~~[[Category: Antibody drug conjugate]]~~	+
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Cancer imaging]]~~	+
-	~~[[Category: Nanobody]]~~	+
-	~~[[Category: Prostate-specific membrane antigen~~]]	+

OCA at 06:00, 5 August 2020

OCA — Wed, 05 Aug 2020 06:00:17 GMT

←Older revision		Revision as of 06:00, 5 August 2020
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	==Crystal structure of NB37, a nanobody targeting prostate specific membrane antigen==		==Crystal structure of NB37, a nanobody targeting prostate specific membrane antigen==
-	<StructureSection load='6xxp' size='340' side='right'caption='[[6xxp]]' scene=''>	+	<StructureSection load='6xxp' size='340' side='right'caption='[[6xxp]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xxp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXP FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxp OCA], [http://pdbe.org/6xxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxp RCSB], [http://www.ebi.ac.uk/pdbsum/6xxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxp ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxp OCA], [http://pdbe.org/6xxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxp RCSB], [http://www.ebi.ac.uk/pdbsum/6xxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxp ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The repertoire of methods for the detection and chemotherapeutic treatment of prostate cancer (PCa) is currently limited. Prostate-specific membrane antigen (PSMA) is overexpressed in PCa tumors and can be exploited for both imaging and drug delivery. We developed and characterized four nanobodies that present tight and specific binding and internalization into PSMA(+) cells and that accumulate specifically in PSMA(+) tumors. We then conjugated one of these nanobodies to the cytotoxic drug doxorubicin, and we show that the conjugate internalizes specifically into PSMA(+) cells, where the drug is released and induces cytotoxic activity. In vivo studies show that the extent of tumor growth inhibition is similar when mice are treated with commercial doxorubicin and with a 42-fold lower amount of the nanobody-conjugated doxorubicin, attesting to the efficacy of the conjugated drug. These data highlight nanobodies as promising agents for the imaging of PCa tumors and for the targeted delivery of chemotherapeutic drugs.
		+
		+	Nanobodies Targeting Prostate-Specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer.,Rosenfeld L, Sananes A, Zur Y, Cohen S, Dhara K, Gelkop S, Ben Zeev E, Shahar A, Lobel L, Akabayov B, Arbely E, Papo N J Med Chem. 2020 Jun 8. doi: 10.1021/acs.jmedchem.0c00418. PMID:32442375<ref>PMID:32442375</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xxp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arabian camel]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Papo N]]	+	[[Category: Papo, N]]
-	[[Category: Rosenfeld L]]	+	[[Category: Rosenfeld, L]]
-	[[Category: Shahar A]]	+	[[Category: Shahar, A]]
		+	[[Category: Anti-cancer drugs]]
		+	[[Category: Antibody drug conjugate]]
		+	[[Category: Antitumor protein]]
		+	[[Category: Cancer imaging]]
		+	[[Category: Nanobody]]
		+	[[Category: Prostate-specific membrane antigen]]

OCA at 06:29, 10 June 2020

OCA — Wed, 10 Jun 2020 06:29:47 GMT

←Older revision		Revision as of 06:29, 10 June 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6xxp is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of NB37, a nanobody targeting prostate specific membrane antigen==
-		+	<StructureSection load='6xxp' size='340' side='right'caption='[[6xxp]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxp OCA], [http://pdbe.org/6xxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxp RCSB], [http://www.ebi.ac.uk/pdbsum/6xxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Papo N]]
		+	[[Category: Rosenfeld L]]
		+	[[Category: Shahar A]]

OCA: Protected "6xxp" [edit=sysop:move=sysop]

OCA — Wed, 05 Feb 2020 06:28:35 GMT

Protected "6xxp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:28, 5 February 2020

OCA: New page: '''Unreleased structure''' The entry 6xxp is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Feb 2020 06:28:34 GMT

New page: '''Unreleased structure''' The entry 6xxp is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6xxp is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]