6xzv - Revision history

OCA at 10:53, 15 November 2023

OCA — Wed, 15 Nov 2023 10:53:35 GMT

←Older revision		Revision as of 10:53, 15 November 2023
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-	====	+	==Structure of zVDR LBD-Calcitriol in complex with chimera 18==
-	<StructureSection load='6xzv' size='340' side='right'caption='[[6xzv]]' scene=''>	+	<StructureSection load='6xzv' size='340' side='right'caption='[[6xzv]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6xzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XZV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xzv OCA], [https://pdbe.org/6xzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xzv RCSB], [https://www.ebi.ac.uk/pdbsum/6xzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xzv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2Z:[(2~{S})-2-azanylpropyl]carbamic+acid'>G2Z</scene>, <scene name='pdbligand=MFH:[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propyl]carbamic+acid'>MFH</scene>, <scene name='pdbligand=UIA:[(2~{R})-1-azanylpropan-2-yl]carbamic+acid'>UIA</scene>, <scene name='pdbligand=URL:[(2~{S})-2-azanyl-4-methyl-pentyl]carbamic+acid'>URL</scene>, <scene name='pdbligand=URV:[(2~{S})-2-azanyl-3-methyl-butyl]carbamic+acid'>URV</scene>, <scene name='pdbligand=UZN:[(2~{S})-2-azanylhexyl]carbamic+acid'>UZN</scene>, <scene name='pdbligand=VDX:5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL'>VDX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xzv OCA], [https://pdbe.org/6xzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xzv RCSB], [https://www.ebi.ac.uk/pdbsum/6xzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xzv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Efficient optimization of a peptide lead into a drug candidate frequently needs further transformation to augment properties such as bioavailability. Among the different options, foldamers, which are sequence-based oligomers with precise folded conformation, have emerged as a promising technology. We introduce oligourea foldamers to reduce the peptide character of inhibitors of protein-protein interactions (PPI). However, the precise design of such mimics is currently limited by the lack of structural information on how these foldamers adapt to protein surfaces. We report a collection of X-ray structures of peptide-oligourea hybrids in complex with ubiquitin ligase MDM2 and vitamin D receptor and show how such hybrid oligomers can be designed to bind with high affinity to protein targets. This work should enable the generation of more effective foldamer-based disruptors of PPIs in the context of peptide lead optimization.
		+
		+	Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers.,Cussol L, Mauran-Ambrosino L, Buratto J, Belorusova AY, Neuville M, Osz J, Fribourg S, Fremaux J, Dolain C, Goudreau SR, Rochel N, Guichard G Angew Chem Int Ed Engl. 2020 Sep 16. doi: 10.1002/anie.202008992. PMID:32935897<ref>PMID:32935897</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6xzv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Vitamin D receptor 3D structures\|Vitamin D receptor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Belorusova AY]]
		+	[[Category: Buratto J]]
		+	[[Category: Guichard G]]
		+	[[Category: Rochel N]]

OCA at 09:57, 17 February 2021

OCA — Wed, 17 Feb 2021 09:57:18 GMT

←Older revision		Revision as of 09:57, 17 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6xzv ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6xzv' size='340' side='right'caption='[[6xzv]]' scene=''>
-	~~Authors~~: ~~Buratto, J~~.~~, Belorusova, A~~.Y.~~, Rochel, N~~.~~, Guichard, G~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structure of zVDR LBD-Calcitriol in complex with chimera 18~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xzv OCA], [https://pdbe.org/6xzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xzv RCSB], [https://www.ebi.ac.uk/pdbsum/6xzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xzv ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Belorusova, A~~.Y]]	+	__TOC__
-	[~~[Category~~: ~~Guichard~~, G]]	+	</StructureSection>
-	[[Category: ~~Buratto, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Rochel, N~~]]	+	[[Category: Z-disk]]

OCA at 07:07, 22 July 2020

OCA — Wed, 22 Jul 2020 07:07:41 GMT

←Older revision		Revision as of 07:07, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6xzv is ON HOLD	+	The entry 6xzv is ON HOLD until Paper Publication

	Authors: Buratto, J., Belorusova, A.Y., Rochel, N., Guichard, G.		Authors: Buratto, J., Belorusova, A.Y., Rochel, N., Guichard, G.

OCA: Protected "6xzv" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2020 02:55:14 GMT

Protected "6xzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:55, 13 February 2020

OCA: New page: '''Unreleased structure''' The entry 6xzv is ON HOLD Authors: Buratto, J., Belorusova, A.Y., Rochel, N., Guichard, G. Description: Structure of zVDR LBD-Calcitriol in complex with chim...

OCA — Thu, 13 Feb 2020 02:55:12 GMT

New page: '''Unreleased structure''' The entry 6xzv is ON HOLD Authors: Buratto, J., Belorusova, A.Y., Rochel, N., Guichard, G. Description: Structure of zVDR LBD-Calcitriol in complex with chim...

New page

'''Unreleased structure'''

The entry 6xzv is ON HOLD

Authors: Buratto, J., Belorusova, A.Y., Rochel, N., Guichard, G.

Description: Structure of zVDR LBD-Calcitriol in complex with chimera 18
[[Category: Unreleased Structures]]
[[Category: Belorusova, A.Y]]
[[Category: Guichard, G]]
[[Category: Buratto, J]]
[[Category: Rochel, N]]