6y6s - Revision history

OCA at 13:20, 24 January 2024

OCA — Wed, 24 Jan 2024 13:20:37 GMT

←Older revision		Revision as of 13:20, 24 January 2024
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	==Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8==		==Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8==
-	<StructureSection load='6y6s' size='340' side='right'caption='[[6y6s]]' scene=''>	+	<StructureSection load='6y6s' size='340' side='right'caption='[[6y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Y6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y6S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6s OCA], [~~http~~://pdbe.org/6y6s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6y6s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6y6s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ODW:(1~{R},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol'>ODW</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6s OCA], [https://pdbe.org/6y6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y6s RCSB], [https://www.ebi.ac.uk/pdbsum/6y6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GALC_MOUSE GALC_MOUSE] Defects in Galc are the cause of the 'twitcher' phenotype; an autosomal recessive leukodystrophy similar to the human disease (Krabbe disease). This deficiency results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GALC_MOUSE GALC_MOUSE] Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.<ref>PMID:8769874</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Competitive inhibitors of galactocerebrosidase (GALC) could be candidates for pharmacological chaperone therapy of patients with Krabbe disease. The known and selective nortropane-type iminosugar galacto-noeurostegine has been found to competitively inhibit GALC with K (i) = 7 muM at pH 4.6, which is 330-fold more potent than the analogous deoxynoeurostegine. It was shown through X-ray protein crystallography that galacto-noeurostegine binds to the active site of GALC in its bicyclic form.
		+
		+	The Bicyclic Form of galacto-Noeurostegine Is a Potent Inhibitor of beta-Galactocerebrosidase.,Viuff A, Salamone S, McLoughlin J, Deane JE, Jensen HH ACS Med Chem Lett. 2020 Dec 18;12(1):56-59. doi: 10.1021/acsmedchemlett.0c00377. , eCollection 2021 Jan 14. PMID:33488964<ref>PMID:33488964</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6y6s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galactosylceramidase\|Galactosylceramidase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
	[[Category: Deane JE]]		[[Category: Deane JE]]
	[[Category: McLoughlin J]]		[[Category: McLoughlin J]]

OCA at 05:50, 20 January 2021

OCA — Wed, 20 Jan 2021 05:50:38 GMT

←Older revision		Revision as of 05:50, 20 January 2021
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-	'''Unreleased structure'''

-	~~The entry 6y6s is ON HOLD until Paper Publication~~	+	==Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8==
-		+	<StructureSection load='6y6s' size='340' side='right'caption='[[6y6s]]' scene=''>
-	~~Authors: Deane, J.E., McLoughlin, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y6S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y6S FirstGlance]. <br>
-	~~Description:~~ Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y6s OCA], [http://pdbe.org/6y6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y6s RCSB], [http://www.ebi.ac.uk/pdbsum/6y6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y6s ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Mcloughlin, J~~]]	+	__TOC__
-	[[Category: ~~Deane,~~ J.E]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Deane JE]]
		+	[[Category: McLoughlin J]]

OCA at 06:14, 11 March 2020

OCA — Wed, 11 Mar 2020 06:14:32 GMT

←Older revision		Revision as of 06:14, 11 March 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6y6s is ON HOLD	+	The entry 6y6s is ON HOLD until Paper Publication

	Authors: Deane, J.E., McLoughlin, J.		Authors: Deane, J.E., McLoughlin, J.
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	Description: Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8		Description: Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Deane, J.E]]
	[[Category: Mcloughlin, J]]		[[Category: Mcloughlin, J]]
		+	[[Category: Deane, J.E]]

OCA: Protected "6y6s" [edit=sysop:move=sysop]

OCA — Wed, 04 Mar 2020 05:47:37 GMT

Protected "6y6s" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:47, 4 March 2020

OCA: New page: '''Unreleased structure''' The entry 6y6s is ON HOLD Authors: Deane, J.E., McLoughlin, J. Description: Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8 [[C...

OCA — Wed, 04 Mar 2020 05:47:36 GMT

New page: '''Unreleased structure''' The entry 6y6s is ON HOLD Authors: Deane, J.E., McLoughlin, J. Description: Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8 [[C...

New page

'''Unreleased structure'''

The entry 6y6s is ON HOLD

Authors: Deane, J.E., McLoughlin, J.

Description: Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8
[[Category: Unreleased Structures]]
[[Category: Deane, J.E]]
[[Category: Mcloughlin, J]]