6y7q - Revision history

OCA at 13:21, 24 January 2024

OCA — Wed, 24 Jan 2024 13:21:13 GMT

←Older revision		Revision as of 13:21, 24 January 2024
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	<StructureSection load='6y7q' size='340' side='right'caption='[[6y7q]], [[Resolution\|resolution]] 1.39Å' scene=''>		<StructureSection load='6y7q' size='340' side='right'caption='[[6y7q]], [[Resolution\|resolution]] 1.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6y7q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y7Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Y7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y7Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.39Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5va1\|5va1]]~~, ~~[[5va2\|5va2]], [[5va3\|5va3]]</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">KCNH7, ERG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y7q OCA], [https://pdbe.org/6y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y7q RCSB], [https://www.ebi.ac.uk/pdbsum/6y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y7q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y7q OCA], [~~http~~://pdbe.org/6y7q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6y7q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6y7q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6y7q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KCNH7_HUMAN KCNH7_HUMAN]] Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.	+	[https://www.uniprot.org/uniprot/KCNH7_HUMAN KCNH7_HUMAN] Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cresser-Brown, J]]	+	[[Category: Cresser-Brown J]]
-	[[Category: Moody, P]]	+	[[Category: Moody P]]
-	[[Category: Raven, E]]	+	[[Category: Raven E]]
-	~~[[Category: Heme binding]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Pa]]~~	+
-	~~[[Category: Potassium channel]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 07:48, 30 September 2020

OCA — Wed, 30 Sep 2020 07:48:03 GMT

←Older revision		Revision as of 07:48, 30 September 2020
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	==Crystal Structure of the N-terminal PAS domain from the hERG3 Potassium Channel==		==Crystal Structure of the N-terminal PAS domain from the hERG3 Potassium Channel==
-	<StructureSection load='6y7q' size='340' side='right'caption='[[6y7q]]' scene=''>	+	<StructureSection load='6y7q' size='340' side='right'caption='[[6y7q]], [[Resolution\|resolution]] 1.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y7Q FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y7q OCA], [http://pdbe.org/6y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y7q RCSB], [http://www.ebi.ac.uk/pdbsum/6y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y7q ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5va1\|5va1]], [[5va2\|5va2]], [[5va3\|5va3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KCNH7, ERG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y7q OCA], [http://pdbe.org/6y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y7q RCSB], [http://www.ebi.ac.uk/pdbsum/6y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y7q ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCNH7_HUMAN KCNH7_HUMAN]] Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ether-a-go-go (EAG) family of voltage gated K+ channels are important regulators of neuronal and cardiac action potential firing (excitability) and have major roles in human diseases such as epilepsy, schizophrenia, cancer and sudden cardiac death. A defining feature of EAG (Kv10-12) channels is a highly conserved domain on the amino-terminus, known as the eag-domain, consisting of a PAS domain capped by a short sequence containing an amphipathic helix (Cap-domain). The PAS and Cap domains are both vital for the normal function of EAG channels. Using heme-affinity pull-down assays and proteomics of lysates from primary cortical neurons, we identified that an EAG channel, hERG3 (Kv11.3), binds to heme. In whole cell electrophysiology experiments, we identified that heme inhibits hERG3 channel activity. In addition, we expressed the Cap and PAS domain of hERG3 in E.coli and, using spectroscopy and kinetics, identified the PAS domain as the location for heme binding. The results identify heme as a regulator of hERG3 channel activity. These observations are discussed in the context of the emerging role for heme as a regulator of ion channel activity in cells.
		+
		+	Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.,Burton MJ, Cresser-Brown J, Thomas M, Portolano N, Basran J, Freeman SL, Kwon H, Bottrill AR, Llansola-Portoles MJ, Pascal AA, Jukes-Jones R, Chernova T, Schmid R, Davies NW, Storey NM, Dorlet P, Moody PCE, Mitcheson JS, Raven EL J Biol Chem. 2020 Jul 28. pii: RA120.014150. doi: 10.1074/jbc.RA120.014150. PMID:32723862<ref>PMID:32723862</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6y7q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cresser-Brown J]]	+	[[Category: Cresser-Brown, J]]
-	[[Category: Moody P]]	+	[[Category: Moody, P]]
-	[[Category: Raven E]]	+	[[Category: Raven, E]]
		+	[[Category: Heme binding]]
		+	[[Category: Membrane protein]]
		+	[[Category: Pa]]
		+	[[Category: Potassium channel]]
		+	[[Category: Rossmann fold]]

OCA at 09:49, 12 August 2020

OCA — Wed, 12 Aug 2020 09:49:21 GMT

←Older revision		Revision as of 09:49, 12 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6y7q is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of the N-terminal PAS domain from the hERG3 Potassium Channel==
-		+	<StructureSection load='6y7q' size='340' side='right'caption='[[6y7q]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y7Q FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y7q OCA], [http://pdbe.org/6y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y7q RCSB], [http://www.ebi.ac.uk/pdbsum/6y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y7q ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cresser-Brown J]]
		+	[[Category: Moody P]]
		+	[[Category: Raven E]]

OCA at 07:12, 22 July 2020

OCA — Wed, 22 Jul 2020 07:12:39 GMT

←Older revision		Revision as of 07:12, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6y7q is ON HOLD	+	The entry 6y7q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6y7q" [edit=sysop:move=sysop]

OCA — Wed, 11 Mar 2020 06:16:05 GMT

Protected "6y7q" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:16, 11 March 2020

OCA: New page: '''Unreleased structure''' The entry 6y7q is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Mar 2020 06:16:03 GMT

New page: '''Unreleased structure''' The entry 6y7q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6y7q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]