6y9c - Revision history

OCA at 11:52, 1 February 2024

OCA — Thu, 01 Feb 2024 11:52:21 GMT

←Older revision		Revision as of 11:52, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6y9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y9C FirstGlance]. <br>		<table><tr><td colspan='2'>[[6y9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y9C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y9c OCA], [https://pdbe.org/6y9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y9c RCSB], [https://www.ebi.ac.uk/pdbsum/6y9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y9c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y9c OCA], [https://pdbe.org/6y9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y9c RCSB], [https://www.ebi.ac.uk/pdbsum/6y9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y9c ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:39, 18 January 2023

OCA — Wed, 18 Jan 2023 07:39:56 GMT

←Older revision		Revision as of 07:39, 18 January 2023
Line 1:		Line 1:

	==The structure of a quaternary ammonium Rieske monooxygenase reveals insights into carnitine oxidation by gut microbiota and inter-subunit electron transfer==		==The structure of a quaternary ammonium Rieske monooxygenase reveals insights into carnitine oxidation by gut microbiota and inter-subunit electron transfer==
-	<StructureSection load='6y9c' size='340' side='right'caption='[[6y9c]]' scene=''>	+	<StructureSection load='6y9c' size='340' side='right'caption='[[6y9c]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y9C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6y9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y9C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y9c OCA], [https://pdbe.org/6y9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y9c RCSB], [https://www.ebi.ac.uk/pdbsum/6y9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y9c ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y9c OCA], [https://pdbe.org/6y9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y9c RCSB], [https://www.ebi.ac.uk/pdbsum/6y9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y9c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CNTA_ACIB2 CNTA_ACIB2] Converts carnitine to trimethylamine and malic semialdehyde.[HAMAP-Rule:MF_02097]<ref>PMID:24591617</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rieske monooxygenases undertake complex catalysis integral to marine, terrestrial and human gut-ecosystems. Group-I to IV Rieske monooxygenases accept aromatic substrates and have well characterised catalytic mechanisms. Nascent to our understanding are Group-V members catalysing the oxidation/breakdown of quaternary ammonium substrates. Phylogenetic analysis of Group V highlights a cysteine residue-pair adjacent to the mononuclear Fe active site with no established role. Following our elucidation of the carnitine monooxygenase CntA structure, we probed the function of the cysteine pair Cys206/Cys209. Utilising biochemical and biophysical techniques, we found the cysteine residues do not play a structural role nor influence the electron transfer pathway, but rather are used in a non-stoichiometric role to ensure the catalytic iron centre remains in an Fe(II) state.
		+
		+	Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site.,Quareshy M, Shanmugam M, Cameron AD, Bugg TDH, Chen Y FEBS J. 2023 Jan 8. doi: 10.1111/febs.16722. PMID:36617384<ref>PMID:36617384</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6y9c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acinetobacter baumannii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bugg TD]]		[[Category: Bugg TD]]

OCA at 10:29, 31 March 2021

OCA — Wed, 31 Mar 2021 10:29:43 GMT

←Older revision		Revision as of 10:29, 31 March 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6y9c is ~~ON HOLD until Paper Publication~~	+	==The structure of a quaternary ammonium Rieske monooxygenase reveals insights into carnitine oxidation by gut microbiota and inter-subunit electron transfer==
-		+	<StructureSection load='6y9c' size='340' side='right'caption='[[6y9c]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y9C FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y9c OCA], [https://pdbe.org/6y9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y9c RCSB], [https://www.ebi.ac.uk/pdbsum/6y9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y9c ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bugg TD]]
		+	[[Category: Cameron A]]
		+	[[Category: Chen Y]]
		+	[[Category: Quareshy M]]
		+	[[Category: Shanmugam M]]

OCA: Protected "6y9c" [edit=sysop:move=sysop]

OCA — Wed, 18 Mar 2020 08:38:55 GMT

Protected "6y9c" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:38, 18 March 2020

OCA: New page: '''Unreleased structure''' The entry 6y9c is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Mar 2020 08:38:54 GMT

New page: '''Unreleased structure''' The entry 6y9c is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6y9c is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]