6yaw - Revision history

OCA at 13:23, 24 January 2024

OCA — Wed, 24 Jan 2024 13:23:10 GMT

←Older revision		Revision as of 13:23, 24 January 2024
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	<StructureSection load='6yaw' size='340' side='right'caption='[[6yaw]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='6yaw' size='340' side='right'caption='[[6yaw]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6yaw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YAW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6YAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yaw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YAW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P9H:(2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic+acid'>P9H</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P9H:(2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic+acid'>P9H</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yaw OCA], [~~http~~://pdbe.org/6yaw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6yaw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6yaw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6yaw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yaw OCA], [https://pdbe.org/6yaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yaw RCSB], [https://www.ebi.ac.uk/pdbsum/6yaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yaw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>	+	[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6yaw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6yaw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Neiers, F]]	+	[[Category: Neiers F]]
-	[[Category: Schwartz, M]]	+	[[Category: Schwartz M]]
-	~~[[Category: Detoxification]]~~	+
-	~~[[Category: Glutathione transferase]]~~	+
-	~~[[Category: Metabolism]]~~	+
-	~~[[Category: Olfaction]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:55, 18 November 2020

OCA — Wed, 18 Nov 2020 09:55:00 GMT

←Older revision		Revision as of 09:55, 18 November 2020
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	<StructureSection load='6yaw' size='340' side='right'caption='[[6yaw]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='6yaw' size='340' side='right'caption='[[6yaw]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6yaw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YAW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yaw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YAW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YAW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P9H:(2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic+acid'>P9H</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P9H:(2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic+acid'>P9H</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yaw OCA], [http://pdbe.org/6yaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yaw RCSB], [http://www.ebi.ac.uk/pdbsum/6yaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yaw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yaw OCA], [http://pdbe.org/6yaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yaw RCSB], [http://www.ebi.ac.uk/pdbsum/6yaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yaw ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Neiers, F]]		[[Category: Neiers, F]]

OCA at 07:11, 2 September 2020

OCA — Wed, 02 Sep 2020 07:11:40 GMT

←Older revision		Revision as of 07:11, 2 September 2020
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	==Crystal structure of human GSTA1-1 bound to the glutathione adduct of cinnamaldehyde==		==Crystal structure of human GSTA1-1 bound to the glutathione adduct of cinnamaldehyde==
-	<StructureSection load='6yaw' size='340' side='right'caption='[[6yaw]]' scene=''>	+	<StructureSection load='6yaw' size='340' side='right'caption='[[6yaw]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YAW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yaw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YAW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YAW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yaw OCA], [http://pdbe.org/6yaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yaw RCSB], [http://www.ebi.ac.uk/pdbsum/6yaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yaw ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P9H:(2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic+acid'>P9H</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yaw OCA], [http://pdbe.org/6yaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yaw RCSB], [http://www.ebi.ac.uk/pdbsum/6yaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yaw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Xenobiotic metabolizing enzymes and other proteins, including odorant-binding proteins located in the nasal epithelium and mucus, participate in a series of processes modulating the concentration of odorants in the environment of olfactory receptors and finely impact odor perception. These enzymes and transporters are thought to participate in odorant degradation or transport. Odorant biotransformation results in (i) changes in the odorant quantity up to their clearance and the termination of signalling and (ii) the formation of new odorant stimuli (metabolites). Enzymes, such as cytochrome P450 and glutathione transferases (GSTs), have been proposed to participate in odorant clearance in insects and mammals as odorant metabolizing enzymes. This study aims to explore the function of GSTs in human olfaction. Using immunohistochemical methods, GSTs were found to be localized in human tissues surrounding the olfactory epithelium. Then, the activity of two members of the GST family towards odorants was measured using heterologously expressed enzymes. The interactions/reactions with odorants were further characterized using a combination of enzymatic techniques. Furthermore, the structure of the complex between human GSTA1 and the glutathione conjugate of an odorant was determined by X-ray crystallography. Our results strongly suggest the role of human GSTs in the modulation of odorant availability to olfactory receptors in the peripheral olfactory process.
		+
		+	Interactions between Odorants and Glutathione Transferases in the Human Olfactory Cleft.,Schwartz M, Menetrier F, Heydel JM, Chavanne E, Faure P, Labrousse M, Lirussi F, Canon F, Mannervik B, Briand L, Neiers F Chem Senses. 2020 Aug 21. pii: 5895478. doi: 10.1093/chemse/bjaa055. PMID:32822468<ref>PMID:32822468</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yaw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Neiers F]]	+	[[Category: Neiers, F]]
-	[[Category: Schwartz M]]	+	[[Category: Schwartz, M]]
		+	[[Category: Detoxification]]
		+	[[Category: Glutathione transferase]]
		+	[[Category: Metabolism]]
		+	[[Category: Olfaction]]
		+	[[Category: Transferase]]

OCA at 11:18, 26 August 2020

OCA — Wed, 26 Aug 2020 11:18:07 GMT

←Older revision		Revision as of 11:18, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6yaw ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of human GSTA1-1 bound to the glutathione adduct of cinnamaldehyde==
-		+	<StructureSection load='6yaw' size='340' side='right'caption='[[6yaw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YAW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YAW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yaw OCA], [http://pdbe.org/6yaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yaw RCSB], [http://www.ebi.ac.uk/pdbsum/6yaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yaw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Neiers F]]
		+	[[Category: Schwartz M]]

OCA at 05:21, 29 April 2020

OCA — Wed, 29 Apr 2020 05:21:41 GMT

←Older revision		Revision as of 05:21, 29 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yaw is ON HOLD	+	The entry 6yaw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6yaw" [edit=sysop:move=sysop]

OCA — Fri, 27 Mar 2020 08:33:55 GMT

Protected "6yaw" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:33, 27 March 2020

OCA: New page: '''Unreleased structure''' The entry 6yaw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 27 Mar 2020 08:33:54 GMT

New page: '''Unreleased structure''' The entry 6yaw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6yaw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]