OCA at 13:24, 24 January 2024

OCA — Wed, 24 Jan 2024 13:24:25 GMT

←Older revision		Revision as of 13:24, 24 January 2024
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-	====	+	==Plasmodium falciparum Myosin A full-length, pre-powerstroke state==
-	<StructureSection load='6ycx' size='340' side='right'caption='[[6ycx]]' scene=''>	+	<StructureSection load='6ycx' size='340' side='right'caption='[[6ycx]], [[Resolution\|resolution]] 3.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ycx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_NF54 Plasmodium falciparum NF54]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YCX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ycx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ycx OCA], [~~http~~://pdbe.org/6ycx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ycx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ycx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ycx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.99Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ycx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ycx OCA], [https://pdbe.org/6ycx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ycx RCSB], [https://www.ebi.ac.uk/pdbsum/6ycx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ycx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MYOA_PLAF7 MYOA_PLAF7] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parasites from the genus Plasmodium are the causative agents of malaria. The mobility, infectivity, and ultimately pathogenesis of Plasmodium falciparum rely on a macromolecular complex, called the glideosome. At the core of the glideosome is an essential and divergent Myosin A motor (PfMyoA), a first order drug target against malaria. Here, we present the full-length structure of PfMyoA in two states of its motor cycle. We report novel interactions that are essential for motor priming and the mode of recognition of its two light chains (PfELC and MTIP) by two degenerate IQ motifs. Kinetic and motility assays using PfMyoA variants, along with molecular dynamics, demonstrate how specific priming and atypical sequence adaptations tune the motor's mechano-chemical properties. Supported by evidence for an essential role of the PfELC in malaria pathogenesis, these structures provide a blueprint for the design of future anti-malarials targeting both the glideosome motor and its regulatory elements.
		+
		+	Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets.,Moussaoui D, Robblee JP, Auguin D, Krementsova EB, Haase S, Blake TCA, Baum J, Robert-Paganin J, Trybus KM, Houdusse A Elife. 2020 Oct 13;9:e60581. doi: 10.7554/eLife.60581. PMID:33046215<ref>PMID:33046215</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ycx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Plasmodium falciparum 3D7]]
		+	[[Category: Plasmodium falciparum NF54]]
		+	[[Category: Auguin D]]
		+	[[Category: Houdusse A]]
		+	[[Category: Krementsova EB]]
		+	[[Category: Moussaoui D]]
		+	[[Category: Robblee JP]]
		+	[[Category: Robert-Paganin J]]
		+	[[Category: Trybus KM]]

OCA at 08:00, 11 November 2020

OCA — Wed, 11 Nov 2020 08:00:26 GMT

←Older revision		Revision as of 08:00, 11 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ycx ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6ycx' size='340' side='right'caption='[[6ycx]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ycx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ycx OCA], [http://pdbe.org/6ycx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ycx RCSB], [http://www.ebi.ac.uk/pdbsum/6ycx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ycx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:40, 1 April 2020

OCA — Wed, 01 Apr 2020 07:40:29 GMT

←Older revision		Revision as of 07:40, 1 April 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ycx is ON HOLD	+	The entry 6ycx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ycx" [edit=sysop:move=sysop]

OCA — Fri, 27 Mar 2020 08:39:52 GMT

Protected "6ycx" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:39, 27 March 2020

OCA: New page: '''Unreleased structure''' The entry 6ycx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 27 Mar 2020 08:39:51 GMT

New page: '''Unreleased structure''' The entry 6ycx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ycx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6ycx - Revision history

OCA at 13:24, 24 January 2024

OCA at 08:00, 11 November 2020

OCA at 07:40, 1 April 2020

OCA: Protected "6ycx" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6ycx is ON HOLD Authors: Description: Category: Unreleased Structures