6yf8 - Revision history

OCA at 13:25, 24 January 2024

OCA — Wed, 24 Jan 2024 13:25:30 GMT

←Older revision		Revision as of 13:25, 24 January 2024
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	==DYRK1A with PST001==		==DYRK1A with PST001==
-	<StructureSection load='6yf8' size='340' side='right'caption='[[6yf8]]' scene=''>	+	<StructureSection load='6yf8' size='340' side='right'caption='[[6yf8]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YF8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yf8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YF8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yf8 OCA], [https://pdbe.org/6yf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yf8 RCSB], [https://www.ebi.ac.uk/pdbsum/6yf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yf8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.198Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OPW:~{N}-[5-(5-methoxy-1,3-benzothiazol-2-yl)pyridin-3-yl]ethanamide'>OPW</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yf8 OCA], [https://pdbe.org/6yf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yf8 RCSB], [https://www.ebi.ac.uk/pdbsum/6yf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yf8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Rothweiler U]]		[[Category: Rothweiler U]]

OCA at 06:45, 7 April 2021

OCA — Wed, 07 Apr 2021 06:45:40 GMT

←Older revision		Revision as of 06:45, 7 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6yf8 ~~is ON HOLD until Paper Publication~~	+	==DYRK1A with PST001==
-		+	<StructureSection load='6yf8' size='340' side='right'caption='[[6yf8]]' scene=''>
-	~~Authors~~: ~~Rothweiler~~, U.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YF8 FirstGlance]. <br>
-	~~Description: DYRK1A with PST001~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yf8 OCA], [https://pdbe.org/6yf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yf8 RCSB], [https://www.ebi.ac.uk/pdbsum/6yf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yf8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Rothweiler, U]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rothweiler U]]

OCA at 07:20, 22 July 2020

OCA — Wed, 22 Jul 2020 07:20:41 GMT

←Older revision		Revision as of 07:20, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yf8 is ON HOLD	+	The entry 6yf8 is ON HOLD until Paper Publication

	Authors: Rothweiler, U.		Authors: Rothweiler, U.

OCA: Protected "6yf8" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2020 07:47:33 GMT

Protected "6yf8" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:47, 1 April 2020

OCA: New page: '''Unreleased structure''' The entry 6yf8 is ON HOLD Authors: Rothweiler, U. Description: DYRK1A with PST001 Category: Unreleased Structures Category: Rothweiler, U

OCA — Wed, 01 Apr 2020 07:47:32 GMT

New page: '''Unreleased structure''' The entry 6yf8 is ON HOLD Authors: Rothweiler, U. Description: DYRK1A with PST001 Category: Unreleased Structures Category: Rothweiler, U

New page

'''Unreleased structure'''

The entry 6yf8 is ON HOLD

Authors: Rothweiler, U.

Description: DYRK1A with PST001
[[Category: Unreleased Structures]]
[[Category: Rothweiler, U]]