6yio - Revision history

OCA at 13:27, 24 January 2024

OCA — Wed, 24 Jan 2024 13:27:51 GMT

←Older revision		Revision as of 13:27, 24 January 2024
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-	====	+	==CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD==
-	<StructureSection load='6yio' size='340' side='right'caption='[[6yio]]' scene=''>	+	<StructureSection load='6yio' size='340' side='right'caption='[[6yio]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yio]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YIO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yio OCA], [https://pdbe.org/6yio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yio RCSB], [https://www.ebi.ac.uk/pdbsum/6yio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yio ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yio OCA], [https://pdbe.org/6yio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yio RCSB], [https://www.ebi.ac.uk/pdbsum/6yio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yio ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/IL2RA_HUMAN IL2RA_HUMAN] Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:[https://omim.org/entry/601942 601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:17676041</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IL2RA_HUMAN IL2RA_HUMAN] Receptor for interleukin-2.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the high affinity receptor subunit for IL-2, is a selective target for Treg depletion in mouse and human malignancies; however, anti-human CD25 antibodies have failed to deliver clinical responses against solid tumors due to bystander IL-2 receptor signaling blockade on effector T cells, which limits their anti-tumor activity. Here we demonstrate potent single-agent activity of anti-CD25 antibodies optimized to deplete Tregs whilst preserving IL-2-STAT5 signaling on effector T cells, and demonstrate synergy with immune checkpoint blockade in vivo. Pre-clinical evaluation of an anti-human CD25 (RG6292) antibody with equivalent features demonstrates, in both non-human primates and humanized mouse models, efficient Treg depletion with no overt immune-related toxicities. Our data supports the clinical development of RG6292 and evaluation of novel combination therapies incorporating non-IL-2 blocking anti-CD25 antibodies in clinical studies.
		+
		+	CD25-T(reg)-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity.,Solomon I, Amann M, Goubier A, Arce Vargas F, Zervas D, Qing C, Henry JY, Ghorani E, Akarca AU, Marafioti T, Sledzinska A, Werner Sunderland M, Franz Demane D, Clancy JR, Georgiou A, Salimu J, Merchiers P, Brown MA, Flury R, Eckmann J, Murgia C, Sam J, Jacobsen B, Marrer-Berger E, Boetsch C, Belli S, Leibrock L, Benz J, Koll H, Sutmuller R, Peggs KS, Quezada SA Nat Cancer. 2020 Dec;1(12):1153-1166. doi: 10.1038/s43018-020-00133-0. Epub 2020 , Nov 9. PMID:33644766<ref>PMID:33644766</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yio" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Benz J]]
		+	[[Category: Koll H]]
		+	[[Category: Leibrock L]]

OCA at 10:44, 31 March 2021

OCA — Wed, 31 Mar 2021 10:44:41 GMT

←Older revision		Revision as of 10:44, 31 March 2021
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	<StructureSection load='6yio' size='340' side='right'caption='[[6yio]]' scene=''>		<StructureSection load='6yio' size='340' side='right'caption='[[6yio]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6yio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yio OCA], [~~http~~://pdbe.org/6yio PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6yio RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6yio PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6yio ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yio OCA], [https://pdbe.org/6yio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yio RCSB], [https://www.ebi.ac.uk/pdbsum/6yio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yio ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 08:00, 11 November 2020

OCA — Wed, 11 Nov 2020 08:00:30 GMT

←Older revision		Revision as of 08:00, 11 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6yio ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6yio' size='340' side='right'caption='[[6yio]]' scene=''>
-	~~Authors~~: ~~Benz, J~~.~~, Koll, H~~.~~, Leibrock, L~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yio OCA], [http://pdbe.org/6yio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yio RCSB], [http://www.ebi.ac.uk/pdbsum/6yio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yio ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Benz~~, J]]	+	__TOC__
-	[[Category: ~~Koll, H~~]]	+	</StructureSection>
-	[[Category: ~~Leibrock, L~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:24, 22 July 2020

OCA — Wed, 22 Jul 2020 07:24:02 GMT

←Older revision		Revision as of 07:24, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yio is ON HOLD	+	The entry 6yio is ON HOLD until Paper Publication

	Authors: Benz, J., Koll, H., Leibrock, L.		Authors: Benz, J., Koll, H., Leibrock, L.

OCA: Protected "6yio" [edit=sysop:move=sysop]

OCA — Wed, 08 Apr 2020 05:46:03 GMT

Protected "6yio" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:46, 8 April 2020

OCA: New page: '''Unreleased structure''' The entry 6yio is ON HOLD Authors: Benz, J., Koll, H., Leibrock, L. Description: CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD [[Category: Unrelea...

OCA — Wed, 08 Apr 2020 05:46:01 GMT

New page: '''Unreleased structure''' The entry 6yio is ON HOLD Authors: Benz, J., Koll, H., Leibrock, L. Description: CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 6yio is ON HOLD

Authors: Benz, J., Koll, H., Leibrock, L.

Description: CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD
[[Category: Unreleased Structures]]
[[Category: Benz, J]]
[[Category: Koll, H]]
[[Category: Leibrock, L]]