6yjn - Revision history

OCA at 13:28, 24 January 2024

OCA — Wed, 24 Jan 2024 13:28:30 GMT

←Older revision		Revision as of 13:28, 24 January 2024
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	<StructureSection load='6yjn' size='340' side='right'caption='[[6yjn]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6yjn' size='340' side='right'caption='[[6yjn]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6yjn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pseudomallei"_whitmore_1913 "bacillus~~ pseudomallei~~" whitmore 1913~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YJN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6YJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yjn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YJN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>can_1, can_2, BOC42_16450, CXQ84_19645, DF122_01465, ERS013345_01543, SAMEA1968934_03740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~28450~~ "~~Bacillus pseudomallei~~" ~~Whitmore 1913])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yjn OCA], [https://pdbe.org/6yjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yjn RCSB], [https://www.ebi.ac.uk/pdbsum/6yjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yjn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6yjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yjn OCA], [~~http~~://pdbe.org/6yjn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6yjn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6yjn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6yjn ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q63Y17_BURPS Q63Y17_BURPS]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus pseudomallei whitmore 1913]]
-	[[Category: Carbonate dehydratase]]
-	[[Category: Large Structures]]
-	[[Category: Angeli, A]]
-	[[Category: Ferraroni, M]]
-	[[Category: Beta carbonic anhydrase]]
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
-	[[Category: ~~Lyase~~]]	+	[[Category: Large Structures]]
		+	[[Category: Angeli A]]
		+	[[Category: Ferraroni M]]

OCA at 08:13, 11 November 2020

OCA — Wed, 11 Nov 2020 08:13:32 GMT

←Older revision		Revision as of 08:13, 11 November 2020
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	==Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei.==		==Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei.==
-	<StructureSection load='6yjn' size='340' side='right'caption='[[6yjn]]' scene=''>	+	<StructureSection load='6yjn' size='340' side='right'caption='[[6yjn]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YJN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yjn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YJN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YJN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yjn OCA], [http://pdbe.org/6yjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yjn RCSB], [http://www.ebi.ac.uk/pdbsum/6yjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yjn ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">can_1, can_2, BOC42_16450, CXQ84_19645, DF122_01465, ERS013345_01543, SAMEA1968934_03740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yjn OCA], [http://pdbe.org/6yjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yjn RCSB], [http://www.ebi.ac.uk/pdbsum/6yjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yjn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carbonic anhydrase (CA) is a zinc enzyme that catalyzes the reversible conversion of carbon dioxide to bicarbonate and proton. Currently, CA inhibitors are widely used as antiglaucoma, anticancer, and anti-obesity drugs and for the treatment of neurological disorders. Recently, the potential use of CA inhibitors to fight infections caused by protozoa, fungi, and bacteria has emerged as a new research line. In this article, the X-ray crystal structure of beta-CA from Burkholderia pseudomallei was reported. The X-ray crystal structure of this new enzyme was solved at 2.7 A resolution, revealing a tetrameric type II beta-CA with a "closed" active site in which the zinc is tetrahedrally coordinated to Cys46, Asp48, His102, and Cys105. B. pseudomallei is known to encode at least two CAs, a beta-CA, and a gamma-CA. These proteins, playing a pivotal role in its life cycle and pathogenicity, offer a novel therapeutic opportunity to obtain antibiotics with a different mechanism of action. Furthermore, the new structure can provide a clear view of the beta-CA mechanism of action and the possibility to find selective inhibitors for this class of CAs.
		+
		+	Crystal Structure of a Tetrameric Type II beta-Carbonic Anhydrase from the Pathogenic Bacterium Burkholderia pseudomallei.,Angeli A, Ferraroni M, Pinteala M, Maier SS, Simionescu BC, Carta F, Del Prete S, Capasso C, Supuran CT Molecules. 2020 May 12;25(10). pii: molecules25102269. doi:, 10.3390/molecules25102269. PMID:32408533<ref>PMID:32408533</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yjn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus pseudomallei whitmore 1913]]
		+	[[Category: Carbonate dehydratase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Angeli A]]	+	[[Category: Angeli, A]]
-	[[Category: Ferraroni M]]	+	[[Category: Ferraroni, M]]
		+	[[Category: Beta carbonic anhydrase]]
		+	[[Category: Burkholderia pseudomallei]]
		+	[[Category: Lyase]]

OCA at 06:30, 10 June 2020

OCA — Wed, 10 Jun 2020 06:30:09 GMT

←Older revision		Revision as of 06:30, 10 June 2020
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-	'''Unreleased structure'''

-	~~The entry 6yjn is ON HOLD~~	+	==Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei.==
-		+	<StructureSection load='6yjn' size='340' side='right'caption='[[6yjn]]' scene=''>
-	~~Authors: Angeli, A., Ferraroni, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YJN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YJN FirstGlance]. <br>
-	~~Description:~~ Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yjn OCA], [http://pdbe.org/6yjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yjn RCSB], [http://www.ebi.ac.uk/pdbsum/6yjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yjn ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Ferraroni~~, M]]	+	__TOC__
-	[[Category: Angeli, A]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Angeli A]]
		+	[[Category: Ferraroni M]]

OCA: Protected "6yjn" [edit=sysop:move=sysop]

OCA — Wed, 15 Apr 2020 05:32:31 GMT

Protected "6yjn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 6yjn is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkhold...

OCA — Wed, 15 Apr 2020 05:32:30 GMT

New page: '''Unreleased structure''' The entry 6yjn is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkhold...

New page

'''Unreleased structure'''

The entry 6yjn is ON HOLD

Authors: Angeli, A., Ferraroni, M.

Description: Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei.
[[Category: Unreleased Structures]]
[[Category: Ferraroni, M]]
[[Category: Angeli, A]]