OCA at 10:21, 22 May 2024

OCA — Wed, 22 May 2024 10:21:24 GMT

←Older revision		Revision as of 10:21, 22 May 2024
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-	====	+	==Rix1-Rea1 pre-60S particle - Rix1-subcomplex, body 3 (rigid body refinement)==
-	<StructureSection load='6yle' size='340' side='right'caption='[[6yle]]' scene=''>	+	<StructureSection load='6yle' size='340' side='right'caption='[[6yle]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yle]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YLE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6yle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yle OCA], [~~http~~://pdbe.org/6yle PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6yle RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6yle PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6yle ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yle OCA], [https://pdbe.org/6yle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yle RCSB], [https://www.ebi.ac.uk/pdbsum/6yle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yle ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IPI3_YEAST IPI3_YEAST] Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.<ref>PMID:14759368</ref> <ref>PMID:15528184</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribosome assembly is driven by numerous assembly factors, including the Rix1 complex and the AAA ATPase Rea1. These two assembly factors catalyze 60S maturation at two distinct states, triggering poorly understood large-scale structural transitions that we analyzed by cryo-electron microscopy. Two nuclear pre-60S intermediates were discovered that represent previously unknown states after Rea1-mediated removal of the Ytm1-Erb1 complex and reveal how the L1 stalk develops from a pre-mature nucleolar to a mature-like nucleoplasmic state. A later pre-60S intermediate shows how the central protuberance arises, assisted by the nearby Rix1-Rea1 machinery, which was solved in its pre-ribosomal context to molecular resolution. This revealed a Rix12-Ipi32 tetramer anchored to the pre-60S via Ipi1, strategically positioned to monitor this decisive remodeling. These results are consistent with a general underlying principle that temporarily stabilized immature RNA domains are successively remodeled by assembly factors, thereby ensuring failsafe assembly progression.
		+
		+	Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.,Kater L, Mitterer V, Thoms M, Cheng J, Berninghausen O, Beckmann R, Hurt E Mol Cell. 2020 Aug 20;79(4):615-628.e5. doi: 10.1016/j.molcel.2020.06.032. Epub, 2020 Jul 14. PMID:32668200<ref>PMID:32668200</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yle" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Beckmann R]]
		+	[[Category: Kater L]]

OCA at 11:11, 29 July 2020

OCA — Wed, 29 Jul 2020 11:11:38 GMT

←Older revision		Revision as of 11:11, 29 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6yle ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6yle' size='340' side='right'caption='[[6yle]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yle OCA], [http://pdbe.org/6yle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yle RCSB], [http://www.ebi.ac.uk/pdbsum/6yle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yle ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:27, 22 July 2020

OCA — Wed, 22 Jul 2020 07:27:14 GMT

←Older revision		Revision as of 07:27, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yle is ON HOLD	+	The entry 6yle is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6yle" [edit=sysop:move=sysop]

OCA — Wed, 15 Apr 2020 05:35:28 GMT

Protected "6yle" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:35, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 6yle is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Apr 2020 05:35:27 GMT

New page: '''Unreleased structure''' The entry 6yle is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6yle is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6yle - Revision history

OCA at 10:21, 22 May 2024

OCA at 11:11, 29 July 2020

OCA at 07:27, 22 July 2020

OCA: Protected "6yle" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6yle is ON HOLD Authors: Description: Category: Unreleased Structures