OCA at 10:21, 22 May 2024

OCA — Wed, 22 May 2024 10:21:29 GMT

←Older revision		Revision as of 10:21, 22 May 2024
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-	====	+	==Cryo-EM structure of Tetrahymena thermophila mitochondrial ATP synthase - central stalk/cring==
-	<StructureSection load='6ynw' size='340' side='right'caption='[[6ynw]]' scene=''>	+	<StructureSection load='6ynw' size='340' side='right'caption='[[6ynw]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ynw]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YNW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ynw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ynw OCA], [~~http~~://pdbe.org/6ynw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ynw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ynw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ynw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ynw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ynw OCA], [https://pdbe.org/6ynw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ynw RCSB], [https://www.ebi.ac.uk/pdbsum/6ynw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ynw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q951A5_TETTH Q951A5_TETTH]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitochondrial ATP synthases form functional homodimers to induce cristae curvature that is a universal property of mitochondria. To expand on the understanding of this fundamental phenomenon, we characterized the unique type III mitochondrial ATP synthase in its dimeric and tetrameric form. The cryo-EM structure of a ciliate ATP synthase dimer reveals an unusual U-shaped assembly of 81 proteins, including a substoichiometrically bound ATPTT2, 40 lipids, and co-factors NAD and CoQ. A single copy of subunit ATPTT2 functions as a membrane anchor for the dimeric inhibitor IF1. Type III specific linker proteins stably tie the ATP synthase monomers in parallel to each other. The intricate dimer architecture is scaffolded by an extended subunit-a that provides a template for both intra- and inter-dimer interactions. The latter results in the formation of tetramer assemblies, the membrane part of which we determined to 3.1 A resolution. The structure of the type III ATP synthase tetramer and its associated lipids suggests that it is the intact unit propagating the membrane curvature.
		+
		+	Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.,Flygaard RK, Muhleip A, Tobiasson V, Amunts A Nat Commun. 2020 Oct 22;11(1):5342. doi: 10.1038/s41467-020-18993-6. PMID:33093501<ref>PMID:33093501</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ynw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase 3D structures\|ATPase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Tetrahymena thermophila]]
		+	[[Category: Amunts A]]
		+	[[Category: Kock Flygaard R]]
		+	[[Category: Muhleip A]]

OCA at 07:11, 30 September 2020

OCA — Wed, 30 Sep 2020 07:11:22 GMT

←Older revision		Revision as of 07:11, 30 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ynw ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6ynw' size='340' side='right'caption='[[6ynw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ynw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ynw OCA], [http://pdbe.org/6ynw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ynw RCSB], [http://www.ebi.ac.uk/pdbsum/6ynw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ynw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:23, 29 April 2020

OCA — Wed, 29 Apr 2020 05:23:15 GMT

←Older revision		Revision as of 05:23, 29 April 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ynw is ON HOLD	+	The entry 6ynw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ynw" [edit=sysop:move=sysop]

OCA — Wed, 22 Apr 2020 04:27:14 GMT

Protected "6ynw" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 22 April 2020

OCA: New page: '''Unreleased structure''' The entry 6ynw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Apr 2020 04:27:12 GMT

New page: '''Unreleased structure''' The entry 6ynw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ynw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6ynw - Revision history

OCA at 10:21, 22 May 2024

OCA at 07:11, 30 September 2020

OCA at 05:23, 29 April 2020

OCA: Protected "6ynw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6ynw is ON HOLD Authors: Description: Category: Unreleased Structures