6yse - Revision history

OCA at 11:08, 14 June 2023

OCA — Wed, 14 Jun 2023 11:08:33 GMT

←Older revision		Revision as of 11:08, 14 June 2023
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	==Gp4 from the Pseudomonas phage LUZ24==		==Gp4 from the Pseudomonas phage LUZ24==
-	<StructureSection load='6yse' size='340' side='right'caption='[[6yse~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6yse' size='340' side='right'caption='[[6yse]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6yse]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bpluz Bpluz~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yse]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_virus_LUZ24 Pseudomonas virus LUZ24]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YSE FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gp4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484895 BPLUZ])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yse OCA], [https://pdbe.org/6yse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yse RCSB], [https://www.ebi.ac.uk/pdbsum/6yse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yse ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yse OCA], [https://pdbe.org/6yse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yse RCSB], [https://www.ebi.ac.uk/pdbsum/6yse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yse ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A9J6U1_BPLUZ A9J6U1_BPLUZ]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bpluz]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bdira, F B~~]]	+	[[Category: Pseudomonas virus LUZ24]]
-	[[Category: ~~Dame, R T~~]]	+	[[Category: Bdira FB]]
-	[[Category: ~~Volkov, A N~~]]	+	[[Category: Dame RT]]
-	[[Category: ~~Antimicrobial]]~~	+	[[Category: Volkov AN]]
-	~~[[Category: Gp4]]~~	+
-	~~[[Category: Peptide binding protein]]~~	+
-	~~[[Category: Phage]]~~	+
-	~~[[Category: Pseudomona~~]]	+

OCA at 12:46, 13 October 2021

OCA — Wed, 13 Oct 2021 12:46:20 GMT

←Older revision		Revision as of 12:46, 13 October 2021
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	==Gp4 from the Pseudomonas phage LUZ24==		==Gp4 from the Pseudomonas phage LUZ24==
-	<StructureSection load='6yse' size='340' side='right'caption='[[6yse]]' scene=''>	+	<StructureSection load='6yse' size='340' side='right'caption='[[6yse]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yse]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpluz Bpluz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YSE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yse OCA], [https://pdbe.org/6yse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yse RCSB], [https://www.ebi.ac.uk/pdbsum/6yse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yse ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gp4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484895 BPLUZ])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yse OCA], [https://pdbe.org/6yse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yse RCSB], [https://www.ebi.ac.uk/pdbsum/6yse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yse ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	H-NS family proteins, bacterial xenogeneic silencers, play central roles in genome organization and in the regulation of foreign genes. It is thought that gene repression is directly dependent on the DNA binding modes of H-NS family proteins. These proteins form lateral protofilaments along DNA. Under specific environmental conditions they switch to bridging two DNA duplexes. This switching is a direct effect of environmental conditions on electrostatic interactions between the oppositely charged DNA binding and N-terminal domains of H-NS proteins. The Pseudomonas lytic phage LUZ24 encodes the protein gp4, which modulates the DNA binding and function of the H-NS family protein MvaT of Pseudomonas aeruginosa. However, the mechanism by which gp4 affects MvaT activity remains elusive. In this study, we show that gp4 specifically interferes with the formation and stability of the bridged MvaT-DNA complex. Structural investigations suggest that gp4 acts as an 'electrostatic zipper' between the oppositely charged domains of MvaT protomers, and stabilizes a structure resembling their 'half-open' conformation, resulting in relief of gene silencing and adverse effects on P. aeruginosa growth. The ability to control H-NS conformation and thereby its impact on global gene regulation and growth might open new avenues to fight Pseudomonas multidrug resistance.
		+
		+	Novel anti-repression mechanism of H-NS proteins by a phage protein.,Bdira FB, Erkelens AM, Qin L, Volkov AN, Lippa AM, Bowring N, Boyle AL, Ubbink M, Dove SL, Dame RT Nucleic Acids Res. 2021 Oct 11;49(18):10770-10784. doi: 10.1093/nar/gkab793. PMID:34520554<ref>PMID:34520554</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yse" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bpluz]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bdira FB]]	+	[[Category: Bdira, F B]]
-	[[Category: Dame RT]]	+	[[Category: Dame, R T]]
-	[[Category: Volkov AN]]	+	[[Category: Volkov, A N]]
		+	[[Category: Antimicrobial]]
		+	[[Category: Gp4]]
		+	[[Category: Peptide binding protein]]
		+	[[Category: Phage]]
		+	[[Category: Pseudomona]]

OCA at 09:18, 12 May 2021

OCA — Wed, 12 May 2021 09:18:21 GMT

←Older revision		Revision as of 09:18, 12 May 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6yse is ~~ON HOLD until Paper Publication~~	+	==Gp4 from the Pseudomonas phage LUZ24==
-		+	<StructureSection load='6yse' size='340' side='right'caption='[[6yse]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YSE FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yse OCA], [https://pdbe.org/6yse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yse RCSB], [https://www.ebi.ac.uk/pdbsum/6yse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yse ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bdira FB]]
		+	[[Category: Dame RT]]
		+	[[Category: Volkov AN]]

OCA at 07:33, 22 July 2020

OCA — Wed, 22 Jul 2020 07:33:41 GMT

←Older revision		Revision as of 07:33, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yse is ON HOLD	+	The entry 6yse is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6yse" [edit=sysop:move=sysop]

OCA — Wed, 29 Apr 2020 05:29:25 GMT

Protected "6yse" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:29, 29 April 2020

OCA: New page: '''Unreleased structure''' The entry 6yse is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Apr 2020 05:29:23 GMT

New page: '''Unreleased structure''' The entry 6yse is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6yse is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]