6yvg - Revision history

OCA at 10:51, 17 June 2020

OCA — Wed, 17 Jun 2020 10:51:27 GMT

←Older revision		Revision as of 10:51, 17 June 2020
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	==Crystal structure of MesI (Lpg2505) from Legionella pneumophila==		==Crystal structure of MesI (Lpg2505) from Legionella pneumophila==
-	<StructureSection load='6yvg' size='340' side='right'caption='[[6yvg]]' scene=''>	+	<StructureSection load='6yvg' size='340' side='right'caption='[[6yvg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YVG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YVG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YVG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yvg OCA], [http://pdbe.org/6yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yvg RCSB], [http://www.ebi.ac.uk/pdbsum/6yvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yvg ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg2505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yvg OCA], [http://pdbe.org/6yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yvg RCSB], [http://www.ebi.ac.uk/pdbsum/6yvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yvg ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Persistence and replication of the gram-negative bacterium Legionella pneumophila in the human host cell depend on so-called effector proteins that target diverse cellular functions and modulate them in favor of the pathogen. We solved the crystal structure of the L. pneumophila effector protein MesI de novo to a resolution of 2.2 A. The 34 kDa polypeptide chain folds into two distinct alpha-helical domains. The larger C-terminal domain shows similarity to tetratricopeptide repeat proteins. Using size-exclusion chromatography, we confirmed that MesI binds tightly to full-length SidI and that deletion of either the N- or the C-terminus weakens the interaction. Based on the three-dimensional structure of MesI we suggest a possible binding mode for SidI and identified two homologs of MesI within the proteome of L. pneumophila that do not bind to SidI, but may act as specific inhibitors of other yet to be identified effectors.
		+
		+	Crystal structure of the metaeffector MesI (Lpg2505) from Legionella pneumophila.,Machtens DA, Willerding JM, Eschenburg S, Reubold TF Biochem Biophys Res Commun. 2020 Jun 30;527(3):696-701. doi:, 10.1016/j.bbrc.2020.05.027. Epub 2020 May 15. PMID:32423822<ref>PMID:32423822</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yvg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eschenburg S]]	+	[[Category: Legph]]
-	[[Category: Machtens DA]]	+	[[Category: Eschenburg, S]]
-	[[Category: Reubold TF]]	+	[[Category: Machtens, D A]]
-	[[Category: Willerding JM]]	+	[[Category: Reubold, T F]]
		+	[[Category: Willerding, J M]]
		+	[[Category: Protein binding]]

OCA at 06:30, 10 June 2020

OCA — Wed, 10 Jun 2020 06:30:18 GMT

←Older revision		Revision as of 06:30, 10 June 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6yvg ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of MesI (Lpg2505) from Legionella pneumophila==
-		+	<StructureSection load='6yvg' size='340' side='right'caption='[[6yvg]]' scene=''>
-	~~Authors~~: ~~Machtens~~, D.A., ~~Willerding~~, J.M., ~~Eschenburg, S~~., ~~Reubold, T~~.F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YVG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YVG FirstGlance]. <br>
-	~~Description: Crystal structure of MesI (Lpg2505) from Legionella pneumophila~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yvg OCA], [http://pdbe.org/6yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yvg RCSB], [http://www.ebi.ac.uk/pdbsum/6yvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yvg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Willerding, J.M~~]]	+	__TOC__
-	[[Category: Machtens~~, D.A~~]]	+	</StructureSection>
-	[[Category: ~~Eschenburg, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Reubold, T.F~~]]	+	[[Category: Eschenburg S]]
		+	[[Category: Machtens DA]]
		+	[[Category: Reubold TF]]
		+	[[Category: Willerding JM]]

OCA at 05:17, 3 June 2020

OCA — Wed, 03 Jun 2020 05:17:27 GMT

←Older revision		Revision as of 05:17, 3 June 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yvg is ON HOLD	+	The entry 6yvg is ON HOLD until Paper Publication

	Authors: Machtens, D.A., Willerding, J.M., Eschenburg, S., Reubold, T.F.		Authors: Machtens, D.A., Willerding, J.M., Eschenburg, S., Reubold, T.F.

OCA at 04:13, 13 May 2020

OCA — Wed, 13 May 2020 04:13:52 GMT

←Older revision		Revision as of 04:13, 13 May 2020
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	The entry 6yvg is ON HOLD		The entry 6yvg is ON HOLD

-	Authors: Machtens, D.A., Willerding, J., Eschenburg, S., Reubold, T.F.	+	Authors: Machtens, D.A., Willerding, J.M., Eschenburg, S., Reubold, T.F.

	Description: Crystal structure of MesI (Lpg2505) from Legionella pneumophila		Description: Crystal structure of MesI (Lpg2505) from Legionella pneumophila
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Willerding, J.M]]
	[[Category: Machtens, D.A]]		[[Category: Machtens, D.A]]
	[[Category: Eschenburg, S]]		[[Category: Eschenburg, S]]
	[[Category: Reubold, T.F]]		[[Category: Reubold, T.F]]
-	[[Category: Willerding, J]]

OCA: Protected "6yvg" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2020 04:45:22 GMT

Protected "6yvg" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:45, 6 May 2020

OCA: New page: '''Unreleased structure''' The entry 6yvg is ON HOLD Authors: Machtens, D.A., Willerding, J., Eschenburg, S., Reubold, T.F. Description: Crystal structure of MesI (Lpg2505) from Legion...

OCA — Wed, 06 May 2020 04:45:20 GMT

New page: '''Unreleased structure''' The entry 6yvg is ON HOLD Authors: Machtens, D.A., Willerding, J., Eschenburg, S., Reubold, T.F. Description: Crystal structure of MesI (Lpg2505) from Legion...

New page

'''Unreleased structure'''

The entry 6yvg is ON HOLD

Authors: Machtens, D.A., Willerding, J., Eschenburg, S., Reubold, T.F.

Description: Crystal structure of MesI (Lpg2505) from Legionella pneumophila
[[Category: Unreleased Structures]]
[[Category: Machtens, D.A]]
[[Category: Eschenburg, S]]
[[Category: Reubold, T.F]]
[[Category: Willerding, J]]