6yy4 - Revision history

OCA at 11:08, 14 June 2023

OCA — Wed, 14 Jun 2023 11:08:40 GMT

←Older revision		Revision as of 11:08, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='6yy4' size='340' side='right'caption='[[6yy4]]' scene=''>		<StructureSection load='6yy4' size='340' side='right'caption='[[6yy4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6yy4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YY4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yy4 OCA], [https://pdbe.org/6yy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yy4 RCSB], [https://www.ebi.ac.uk/pdbsum/6yy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yy4 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yy4 OCA], [https://pdbe.org/6yy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yy4 RCSB], [https://www.ebi.ac.uk/pdbsum/6yy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yy4 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G-quadruplexes are noncanonical nucleic acid structures formed by stacked guanine tetrads. They are capable of a range of functions and thought to play widespread biological roles. This diversity raises an important question: what determines the biochemical specificity of G-quadruplex structures? The answer is particularly important from the perspective of biological regulation because genomes can contain hundreds of thousands of G-quadruplexes with a range of functions. Here we analyze the specificity of each sequence in a 496-member library of variants of a reference G-quadruplex with respect to five functions. Our analysis shows that the sequence requirements of G-quadruplexes with these functions are different from one another, with some mutations altering biochemical specificity by orders of magnitude. Mutations in tetrads have larger effects than mutations in loops, and changes in specificity are correlated with changes in multimeric state. To complement our biochemical data we determined the solution structure of a monomeric G-quadruplex from the library. The stacked and accessible tetrads rationalize why monomers tend to promote a model peroxidase reaction and generate fluorescence. Our experiments support a model in which the sequence requirements of G-quadruplexes with different functions are overlapping but distinct. This has implications for biological regulation, bioinformatics, and drug design.
		+
		+	Overlapping but distinct: a new model for G-quadruplex biochemical specificity.,Volek M, Kolesnikova S, Svehlova K, Srb P, Sgallova R, Streckerova T, Redondo JA, Veverka V, Curtis EA Nucleic Acids Res. 2021 Feb 26;49(4):1816-1827. doi: 10.1093/nar/gkab037. PMID:33544841<ref>PMID:33544841</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6yy4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
	[[Category: Curtis C]]		[[Category: Curtis C]]
	[[Category: Srb P]]		[[Category: Srb P]]
	[[Category: Veverka V]]		[[Category: Veverka V]]

OCA at 17:52, 10 March 2021

OCA — Wed, 10 Mar 2021 17:52:50 GMT

←Older revision		Revision as of 17:52, 10 March 2021
Line 3:		Line 3:
	<StructureSection load='6yy4' size='340' side='right'caption='[[6yy4]]' scene=''>		<StructureSection load='6yy4' size='340' side='right'caption='[[6yy4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YY4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6YY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YY4 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6yy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yy4 OCA], [~~http~~://pdbe.org/6yy4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6yy4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6yy4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6yy4 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yy4 OCA], [https://pdbe.org/6yy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yy4 RCSB], [https://www.ebi.ac.uk/pdbsum/6yy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yy4 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 08:12, 20 January 2021

OCA — Wed, 20 Jan 2021 08:12:20 GMT

←Older revision		Revision as of 08:12, 20 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6yy4 ~~is ON HOLD until Paper Publication~~	+	==Parallel 17-mer DNA G-quadruplex==
-		+	<StructureSection load='6yy4' size='340' side='right'caption='[[6yy4]]' scene=''>
-	~~Authors~~: ~~Srb~~, P., ~~Curtis~~, C., ~~Veverka~~, V.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YY4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YY4 FirstGlance]. <br>
-	~~Description: Parallel 17-mer DNA G-quadruplex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yy4 OCA], [http://pdbe.org/6yy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yy4 RCSB], [http://www.ebi.ac.uk/pdbsum/6yy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yy4 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Veverka, V~~]]	+	__TOC__
-	[[Category: Srb, P]]	+	</StructureSection>
-	[[Category: ~~Curtis, C~~]]	+	[[Category: Large Structures]]
		+	[[Category: Curtis C]]
		+	[[Category: Srb P]]
		+	[[Category: Veverka V]]

OCA at 07:39, 22 July 2020

OCA — Wed, 22 Jul 2020 07:39:04 GMT

←Older revision		Revision as of 07:39, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6yy4 is ON HOLD	+	The entry 6yy4 is ON HOLD until Paper Publication

	Authors: Srb, P., Curtis, C., Veverka, V.		Authors: Srb, P., Curtis, C., Veverka, V.

OCA: Protected "6yy4" [edit=sysop:move=sysop]

OCA — Wed, 13 May 2020 04:15:52 GMT

Protected "6yy4" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:15, 13 May 2020

OCA: New page: '''Unreleased structure''' The entry 6yy4 is ON HOLD Authors: Srb, P., Curtis, C., Veverka, V. Description: Parallel 17-mer DNA G-quadruplex Category: Unreleased Structures [[Categ...

OCA — Wed, 13 May 2020 04:15:51 GMT

New page: '''Unreleased structure''' The entry 6yy4 is ON HOLD Authors: Srb, P., Curtis, C., Veverka, V. Description: Parallel 17-mer DNA G-quadruplex Category: Unreleased Structures [[Categ...

New page

'''Unreleased structure'''

The entry 6yy4 is ON HOLD

Authors: Srb, P., Curtis, C., Veverka, V.

Description: Parallel 17-mer DNA G-quadruplex
[[Category: Unreleased Structures]]
[[Category: Veverka, V]]
[[Category: Srb, P]]
[[Category: Curtis, C]]