OCA at 10:22, 22 May 2024

OCA — Wed, 22 May 2024 10:22:47 GMT

←Older revision		Revision as of 10:22, 22 May 2024
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-	====	+	==Structure of the Mrp antiporter complex==
-	<StructureSection load='6z16' size='340' side='right'caption='[[6z16]]' scene=''>	+	<StructureSection load='6z16' size='340' side='right'caption='[[6z16]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z16]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Anoxybacillus_flavithermus_WK1 Anoxybacillus flavithermus WK1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z16 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6z16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z16 OCA], [~~http~~://pdbe.org/6z16 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6z16 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6z16 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6z16 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z16 OCA], [https://pdbe.org/6z16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z16 RCSB], [https://www.ebi.ac.uk/pdbsum/6z16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z16 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B7GL84_ANOFW B7GL84_ANOFW]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multiple resistance and pH adaptation (Mrp) antiporters are multi-subunit Na(+) (or K(+))/H(+) exchangers representing an ancestor of many essential redox-driven proton pumps, such as respiratory complex I. The mechanism of coupling between ion or electron transfer and proton translocation in this large protein family is unknown. Here, we present the structure of the Mrp complex from Anoxybacillus flavithermus solved by cryo-EM at 3.0 A resolution. It is a dimer of seven-subunit protomers with 50 trans-membrane helices each. Surface charge distribution within each monomer is remarkably asymmetric, revealing probable proton and sodium translocation pathways. On the basis of the structure we propose a mechanism where the coupling between sodium and proton translocation is facilitated by a series of electrostatic interactions between a cation and key charged residues. This mechanism is likely to be applicable to the entire family of redox proton pumps, where electron transfer to substrates replaces cation movements.
		+
		+	Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter.,Steiner J, Sazanov L Elife. 2020 Jul 31;9:e59407. doi: 10.7554/eLife.59407. PMID:32735215<ref>PMID:32735215</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6z16" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anoxybacillus flavithermus WK1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Sazanov LA]]
		+	[[Category: Steiner J]]

OCA at 09:50, 12 August 2020

OCA — Wed, 12 Aug 2020 09:50:29 GMT

←Older revision		Revision as of 09:50, 12 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6z16 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6z16' size='340' side='right'caption='[[6z16]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z16 OCA], [http://pdbe.org/6z16 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z16 RCSB], [http://www.ebi.ac.uk/pdbsum/6z16 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z16 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:27, 29 July 2020

OCA — Wed, 29 Jul 2020 09:27:23 GMT

←Older revision		Revision as of 09:27, 29 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6z16 is ON HOLD	+	The entry 6z16 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6z16" [edit=sysop:move=sysop]

OCA — Wed, 20 May 2020 04:31:20 GMT

Protected "6z16" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 20 May 2020

OCA: New page: '''Unreleased structure''' The entry 6z16 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 May 2020 04:31:18 GMT

New page: '''Unreleased structure''' The entry 6z16 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6z16 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6z16 - Revision history

OCA at 10:22, 22 May 2024

OCA at 09:50, 12 August 2020

OCA at 09:27, 29 July 2020

OCA: Protected "6z16" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6z16 is ON HOLD Authors: Description: Category: Unreleased Structures