6z1w - Revision history

OCA at 13:40, 24 January 2024

OCA — Wed, 24 Jan 2024 13:40:10 GMT

←Older revision		Revision as of 13:40, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6z1w' size='340' side='right'caption='[[6z1w]], [[Resolution\|resolution]] 2.48Å' scene=''>		<StructureSection load='6z1w' size='340' side='right'caption='[[6z1w]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6z1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=OXN:OXTOXYNOL~~-~~10'>OXN</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.48Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HSD17B4, EDH17B4, SDR8C1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OXN:OXTOXYNOL-10'>OXN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1w OCA], [https://pdbe.org/6z1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1w RCSB], [https://www.ebi.ac.uk/pdbsum/6z1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1w OCA], [https://pdbe.org/6z1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1w RCSB], [https://www.ebi.ac.uk/pdbsum/6z1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1w ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN]] Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:[https://omim.org/entry/261515 261515]]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.<ref>PMID:9482850</ref> <ref>PMID:10400999</ref> <ref>PMID:11743515</ref> Defects in HSD17B4 are the cause of Perrault syndrome (PRLTS1) [MIM:[https://omim.org/entry/233400 233400]]. A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement.<ref>PMID:20673864</ref>	+	[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:[https://omim.org/entry/261515 261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.<ref>PMID:9482850</ref> <ref>PMID:10400999</ref> <ref>PMID:11743515</ref> Defects in HSD17B4 are the cause of Perrault syndrome (PRLTS1) [MIM:[https://omim.org/entry/233400 233400]. A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement.<ref>PMID:20673864</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN]] Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.<ref>PMID:9089413</ref> <ref>PMID:8902629</ref>	+	[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.<ref>PMID:9089413</ref> <ref>PMID:8902629</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Janssen~~, D B~~]]	+	[[Category: Janssen DB]]
-	[[Category: Rozeboom~~, H J]]~~	+	[[Category: Rozeboom HJ]]
-	~~[[Category: Alfa-beta fold]]~~	+
-	~~[[Category: Hydrophobic tunnel]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein-triton x-100 complex~~]]	+

OCA at 09:34, 15 September 2021

OCA — Wed, 15 Sep 2021 09:34:14 GMT

←Older revision		Revision as of 09:34, 15 September 2021
Line 1:		Line 1:

	==Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C==		==Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C==
-	<StructureSection load='6z1w' size='340' side='right'caption='[[6z1w]]' scene=''>	+	<StructureSection load='6z1w' size='340' side='right'caption='[[6z1w]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1w OCA], [https://pdbe.org/6z1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1w RCSB], [https://www.ebi.ac.uk/pdbsum/6z1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1w ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OXN:OXTOXYNOL-10'>OXN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSD17B4, EDH17B4, SDR8C1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1w OCA], [https://pdbe.org/6z1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1w RCSB], [https://www.ebi.ac.uk/pdbsum/6z1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1w ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN]] Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:[https://omim.org/entry/261515 261515]]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.<ref>PMID:9482850</ref> <ref>PMID:10400999</ref> <ref>PMID:11743515</ref> Defects in HSD17B4 are the cause of Perrault syndrome (PRLTS1) [MIM:[https://omim.org/entry/233400 233400]]. A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement.<ref>PMID:20673864</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN]] Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.<ref>PMID:9089413</ref> <ref>PMID:8902629</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Janssen DB]]	+	[[Category: Janssen, D B]]
-	[[Category: Rozeboom HJ]]	+	[[Category: Rozeboom, H J]]
		+	[[Category: Alfa-beta fold]]
		+	[[Category: Hydrophobic tunnel]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Protein-triton x-100 complex]]

OCA at 14:42, 3 March 2021

OCA — Wed, 03 Mar 2021 14:42:46 GMT

←Older revision		Revision as of 14:42, 3 March 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6z1w is ON HOLD until Paper Publication~~	+	==Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C==
-		+	<StructureSection load='6z1w' size='340' side='right'caption='[[6z1w]]' scene=''>
-	~~Authors: Rozeboom, H.J., Janssen, D.B.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1W FirstGlance]. <br>
-	~~Description:~~ Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1w OCA], [https://pdbe.org/6z1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1w RCSB], [https://www.ebi.ac.uk/pdbsum/6z1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1w ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Janssen~~, D.B~~]]	+	__TOC__
-	[[Category: Rozeboom~~, H.J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Janssen DB]]
		+	[[Category: Rozeboom HJ]]

OCA at 05:02, 27 May 2020

OCA — Wed, 27 May 2020 05:02:14 GMT

←Older revision		Revision as of 05:02, 27 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6z1w is ON HOLD	+	The entry 6z1w is ON HOLD until Paper Publication

	Authors: Rozeboom, H.J., Janssen, D.B.		Authors: Rozeboom, H.J., Janssen, D.B.

OCA: Protected "6z1w" [edit=sysop:move=sysop]

OCA — Wed, 20 May 2020 04:33:54 GMT

Protected "6z1w" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:33, 20 May 2020

OCA: New page: '''Unreleased structure''' The entry 6z1w is ON HOLD Authors: Rozeboom, H.J., Janssen, D.B. Description: Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C [[C...

OCA — Wed, 20 May 2020 04:33:53 GMT

New page: '''Unreleased structure''' The entry 6z1w is ON HOLD Authors: Rozeboom, H.J., Janssen, D.B. Description: Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C [[C...

New page

'''Unreleased structure'''

The entry 6z1w is ON HOLD

Authors: Rozeboom, H.J., Janssen, D.B.

Description: Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C
[[Category: Unreleased Structures]]
[[Category: Janssen, D.B]]
[[Category: Rozeboom, H.J]]