OCA at 13:42, 24 January 2024

OCA — Wed, 24 Jan 2024 13:42:05 GMT

←Older revision		Revision as of 13:42, 24 January 2024
Line 1:		Line 1:

	==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003791==		==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003791==
-	<StructureSection load='6z58' size='340' side='right'caption='[[6z58]]' scene=''>	+	<StructureSection load='6z58' size='340' side='right'caption='[[6z58]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z58 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z58 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z58 OCA], [https://pdbe.org/6z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z58 RCSB], [https://www.ebi.ac.uk/pdbsum/6z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z58 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Q9B:8,14,18,19,22-pentazatetracyclo[13.5.2.12,6.018,21]tricosa-1(21),2,4,6(23),15(22),16,19-heptaen-7-one'>Q9B</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z58 OCA], [https://pdbe.org/6z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z58 RCSB], [https://www.ebi.ac.uk/pdbsum/6z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z58 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>

	==See Also==		==See Also==
	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]		*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Benderitter P]]		[[Category: Benderitter P]]

OCA: Protected "6z58" [edit=sysop:move=sysop]

OCA — Tue, 08 Jun 2021 15:22:55 GMT

Protected "6z58" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:22, 8 June 2021

OCA: New page: ==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003791== == Structural highlights == ...

OCA — Tue, 08 Jun 2021 15:22:54 GMT

New page: ==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003791== <StructureSection load='6z58' size='340' side='right'caption='6z58' scene=''> == Structural highlights == ...

New page

==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003791==
<StructureSection load='6z58' size='340' side='right'caption='[[6z58]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z58 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z58 OCA], [https://pdbe.org/6z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z58 RCSB], [https://www.ebi.ac.uk/pdbsum/6z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z58 ProSAT]</span></td></tr>
</table>

==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Benderitter P]]
[[Category: Chaikuad A]]
[[Category: Denis A]]
[[Category: Hoflack J]]
[[Category: Knapp S]]

6z58 - Revision history

OCA at 13:42, 24 January 2024

OCA: Protected "6z58" [edit=sysop:move=sysop]

OCA: New page: ==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003791== == Structural highlights == ...