6z5j - Revision history

OCA at 10:23, 22 May 2024

OCA — Wed, 22 May 2024 10:23:11 GMT

←Older revision		Revision as of 10:23, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='6z5j' size='340' side='right'caption='[[6z5j]], [[Resolution\|resolution]] 8.00Å' scene=''>		<StructureSection load='6z5j' size='340' side='right'caption='[[6z5j]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6z5j]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~puerto_rico~~/8-~~9nmc3~~/1934(~~h1n1~~)) Influenza a virus (a/~~puerto rico~~/8-~~9nmc3~~/1934(~~h1n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Z5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z5j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8-9NMC3/1934(H1N1)) Influenza A virus (A/Puerto Rico/8-9NMC3/1934(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z5J FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">M1, ~~M (~~[~~http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=760066 Influenza A virus (A/Puerto Rico/8-9NMC3/1934(H1N1))])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6z5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5j OCA], [~~http~~://pdbe.org/6z5j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6z5j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6z5j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5j OCA], [https://pdbe.org/6z5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z5j RCSB], [https://www.ebi.ac.uk/pdbsum/6z5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/F0TTD6_9INFA F0TTD6_9INFA]] Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.[HAMAP-Rule:MF_04068][RuleBase:RU362105] Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.[HAMAP-Rule:MF_04068][RuleBase:RU362105]	+	[https://www.uniprot.org/uniprot/F0TTD6_9INFA F0TTD6_9INFA] Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.[HAMAP-Rule:MF_04068][RuleBase:RU362105] Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.[HAMAP-Rule:MF_04068][RuleBase:RU362105]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briggs~~, J A.G~~]]	+	[[Category: Briggs JAG]]
-	[[Category: Erlendsson, S]]	+	[[Category: Erlendsson S]]
-	[[Category: Kraeusslich, H G]]	+	[[Category: Kraeusslich H-G]]
-	[[Category: Peukes, J]]	+	[[Category: Peukes J]]
-	[[Category: Qu, K]]	+	[[Category: Qu K]]
-	[[Category: Wan, W]]	+	[[Category: Wan W]]
-	[[Category: Xiong, X]]	+	[[Category: Xiong X]]
-	~~[[Category: Membrane binding]]~~	+
-	~~[[Category: Ph sensor]]~~	+
-	~~[[Category: Polymer]]~~	+
-	~~[[Category: Viral matrix protein]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:17, 2 December 2020

OCA — Wed, 02 Dec 2020 08:17:46 GMT

←Older revision		Revision as of 08:17, 2 December 2020
Line 1:		Line 1:

	==Arrangement of the matrix protein M1 in influenza A/Hong Kong/1/1968 VLPs (HA,NA,M1,M2)==		==Arrangement of the matrix protein M1 in influenza A/Hong Kong/1/1968 VLPs (HA,NA,M1,M2)==
-	<StructureSection load='6z5j' size='340' side='right'caption='[[6z5j]]' scene=''>	+	<StructureSection load='6z5j' size='340' side='right'caption='[[6z5j]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z5j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8-9nmc3/1934(h1n1)) Influenza a virus (a/puerto rico/8-9nmc3/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z5J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5j OCA], [http://pdbe.org/6z5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z5j RCSB], [http://www.ebi.ac.uk/pdbsum/6z5j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5j ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M1, M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=760066 Influenza A virus (A/Puerto Rico/8-9NMC3/1934(H1N1))])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5j OCA], [http://pdbe.org/6z5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z5j RCSB], [http://www.ebi.ac.uk/pdbsum/6z5j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/F0TTD6_9INFA F0TTD6_9INFA]] Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.[HAMAP-Rule:MF_04068][RuleBase:RU362105] Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.[HAMAP-Rule:MF_04068][RuleBase:RU362105]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Influenza A virus causes millions of severe cases of disease during annual epidemics. The most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus assembly by forming an endoskeleton beneath the virus membrane(1). The structure of full-length M1, and how it oligomerizes to mediate the assembly of virions, is unknown. Here we determine the complete structure of assembled M1 within intact virus particles, as well as the structure of M1 oligomers reconstituted in vitro. We find that the C-terminal domain of M1 is disordered in solution but can fold and bind in trans to the N-terminal domain of another M1 monomer, thus polymerizing M1 into linear strands that coat the interior surface of the membrane of the assembling virion. In the M1 polymer, five histidine residues-contributed by three different monomers of M1-form a cluster that can serve as the pH-sensitive disassembly switch after entry into a target cell. These structures therefore reveal mechanisms of influenza virus assembly and disassembly.
		+
		+	The native structure of the assembled matrix protein 1 of influenza A virus.,Peukes J, Xiong X, Erlendsson S, Qu K, Wan W, Calder LJ, Schraidt O, Kummer S, Freund SMV, Krausslich HG, Briggs JAG Nature. 2020 Sep 9. pii: 10.1038/s41586-020-2696-8. doi:, 10.1038/s41586-020-2696-8. PMID:32908308<ref>PMID:32908308</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6z5j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briggs ~~JAG~~]]	+	[[Category: Briggs, J A.G]]
-	[[Category: Erlendsson S]]	+	[[Category: Erlendsson, S]]
-	[[Category: Kraeusslich H-G]]	+	[[Category: Kraeusslich, H G]]
-	[[Category: Peukes J]]	+	[[Category: Peukes, J]]
-	[[Category: Qu K]]	+	[[Category: Qu, K]]
-	[[Category: Wan W]]	+	[[Category: Wan, W]]
-	[[Category: Xiong X]]	+	[[Category: Xiong, X]]
		+	[[Category: Membrane binding]]
		+	[[Category: Ph sensor]]
		+	[[Category: Polymer]]
		+	[[Category: Viral matrix protein]]
		+	[[Category: Viral protein]]

OCA at 05:50, 14 October 2020

OCA — Wed, 14 Oct 2020 05:50:29 GMT

←Older revision		Revision as of 05:50, 14 October 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6z5j is ~~ON HOLD until Paper Publication~~	+	==Arrangement of the matrix protein M1 in influenza A/Hong Kong/1/1968 VLPs (HA,NA,M1,M2)==
-		+	<StructureSection load='6z5j' size='340' side='right'caption='[[6z5j]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z5J FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5j OCA], [http://pdbe.org/6z5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z5j RCSB], [http://www.ebi.ac.uk/pdbsum/6z5j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5j ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Briggs JAG]]
		+	[[Category: Erlendsson S]]
		+	[[Category: Kraeusslich H-G]]
		+	[[Category: Peukes J]]
		+	[[Category: Qu K]]
		+	[[Category: Wan W]]
		+	[[Category: Xiong X]]

OCA at 08:48, 17 June 2020

OCA — Wed, 17 Jun 2020 08:48:20 GMT

←Older revision		Revision as of 08:48, 17 June 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6z5j is ON HOLD	+	The entry 6z5j is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6z5j" [edit=sysop:move=sysop]

OCA — Wed, 03 Jun 2020 05:20:45 GMT

Protected "6z5j" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 3 June 2020

OCA: New page: '''Unreleased structure''' The entry 6z5j is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jun 2020 05:20:44 GMT

New page: '''Unreleased structure''' The entry 6z5j is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6z5j is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]