OCA at 10:23, 22 May 2024

OCA — Wed, 22 May 2024 10:23:18 GMT

←Older revision		Revision as of 10:23, 22 May 2024
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-	====	+	==Cryo-EM structure of the A. baumannii MlaBDEF complex bound to APPNHP==
-	<StructureSection load='6z5u' size='340' side='right'caption='[[6z5u]]' scene=''>	+	<StructureSection load='6z5u' size='340' side='right'caption='[[6z5u]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z5u]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z5U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5u OCA], [https://pdbe.org/6z5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z5u RCSB], [https://www.ebi.ac.uk/pdbsum/6z5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5u ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5u OCA], [https://pdbe.org/6z5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z5u RCSB], [https://www.ebi.ac.uk/pdbsum/6z5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5u ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/V5V9F4_ACIBA V5V9F4_ACIBA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multi-resistant bacteria are a major threat in modern medicine. The gram-negative coccobacillus Acinetobacter baumannii currently leads the WHO list of pathogens in critical need for new therapeutic development. The maintenance of lipid asymmetry (MLA) protein complex is one of the core machineries that transport lipids from/to the outer membrane in gram-negative bacteria. It also contributes to broad-range antibiotic resistance in several pathogens, most prominently in A. baumannii. Nonetheless, the molecular details of its role in lipid transport has remained largely elusive. Here, we report the cryo-EM maps of the core MLA complex, MlaBDEF, from the pathogen A. baumannii, in the apo-, ATP- and ADP-bound states, revealing multiple lipid binding sites in the cytosolic and periplasmic side of the complex. Molecular dynamics simulations suggest their potential trajectory across the membrane. Collectively with the recently-reported structures of the E. coli orthologue, this data also allows us to propose a molecular mechanism of lipid transport by the MLA system.
		+
		+	Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii.,Mann D, Fan J, Somboon K, Farrell DP, Muenks A, Tzokov SB, DiMaio F, Khalid S, Miller SI, Bergeron JRC Commun Biol. 2021 Jun 29;4(1):817. doi: 10.1038/s42003-021-02318-4. PMID:34188171<ref>PMID:34188171</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6z5u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acinetobacter baumannii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Bergeron JRC]]
		+	[[Category: Mann D]]

OCA at 08:51, 5 May 2021

OCA — Wed, 05 May 2021 08:51:37 GMT

←Older revision		Revision as of 08:51, 5 May 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6z5u ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6z5u' size='340' side='right'caption='[[6z5u]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z5u OCA], [https://pdbe.org/6z5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z5u RCSB], [https://www.ebi.ac.uk/pdbsum/6z5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z5u ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:45, 22 July 2020

OCA — Wed, 22 Jul 2020 07:45:51 GMT

←Older revision		Revision as of 07:45, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6z5u is ON HOLD	+	The entry 6z5u is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6z5u" [edit=sysop:move=sysop]

OCA — Wed, 03 Jun 2020 05:21:13 GMT

Protected "6z5u" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:21, 3 June 2020

OCA: New page: '''Unreleased structure''' The entry 6z5u is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jun 2020 05:21:12 GMT

New page: '''Unreleased structure''' The entry 6z5u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6z5u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6z5u - Revision history

OCA at 10:23, 22 May 2024

OCA at 08:51, 5 May 2021

OCA at 07:45, 22 July 2020

OCA: Protected "6z5u" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6z5u is ON HOLD Authors: Description: Category: Unreleased Structures