6z6z - Revision history

OCA at 13:42, 24 January 2024

OCA — Wed, 24 Jan 2024 13:42:53 GMT

←Older revision		Revision as of 13:42, 24 January 2024
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	==Crystal structure of an Anticalin directed towards colchicine without ligand==		==Crystal structure of an Anticalin directed towards colchicine without ligand==
-	<StructureSection load='6z6z' size='340' side='right'caption='[[6z6z]]' scene=''>	+	<StructureSection load='6z6z' size='340' side='right'caption='[[6z6z]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6z6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z6Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z6z OCA], [https://pdbe.org/6z6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z6z RCSB], [https://www.ebi.ac.uk/pdbsum/6z6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z6z ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z6z OCA], [https://pdbe.org/6z6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z6z RCSB], [https://www.ebi.ac.uk/pdbsum/6z6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z6z ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref>
		+
		+	==See Also==
		+	*[[Neutrophil gelatinase-associated lipocalin\|Neutrophil gelatinase-associated lipocalin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eichinger A]]		[[Category: Eichinger A]]
	[[Category: Skerra A]]		[[Category: Skerra A]]

OCA at 12:10, 9 June 2021

OCA — Wed, 09 Jun 2021 12:10:06 GMT

←Older revision		Revision as of 12:10, 9 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6z6z ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of an Anticalin directed towards colchicine without ligand==
-		+	<StructureSection load='6z6z' size='340' side='right'caption='[[6z6z]]' scene=''>
-	~~Authors~~: ~~Skerra~~, A., ~~Eichinger~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z6Z FirstGlance]. <br>
-	~~Description: Crystal structure of an Anticalin directed towards colchicine without ligand~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z6z OCA], [https://pdbe.org/6z6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z6z RCSB], [https://www.ebi.ac.uk/pdbsum/6z6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z6z ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Eichinger, A]]	+	__TOC__
-	[[Category: Skerra, A]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Eichinger A]]
		+	[[Category: Skerra A]]

OCA at 07:46, 22 July 2020

OCA — Wed, 22 Jul 2020 07:46:53 GMT

←Older revision		Revision as of 07:46, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6z6z is ON HOLD	+	The entry 6z6z is ON HOLD until Paper Publication

	Authors: Skerra, A., Eichinger, A.		Authors: Skerra, A., Eichinger, A.

OCA: Protected "6z6z" [edit=sysop:move=sysop]

OCA — Wed, 10 Jun 2020 05:07:01 GMT

Protected "6z6z" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:07, 10 June 2020

OCA: New page: '''Unreleased structure''' The entry 6z6z is ON HOLD Authors: Skerra, A., Eichinger, A. Description: Crystal structure of an Anticalin directed towards colchicine without ligand [[Cate...

OCA — Wed, 10 Jun 2020 05:06:59 GMT

New page: '''Unreleased structure''' The entry 6z6z is ON HOLD Authors: Skerra, A., Eichinger, A. Description: Crystal structure of an Anticalin directed towards colchicine without ligand [[Cate...

New page

'''Unreleased structure'''

The entry 6z6z is ON HOLD

Authors: Skerra, A., Eichinger, A.

Description: Crystal structure of an Anticalin directed towards colchicine without ligand
[[Category: Unreleased Structures]]
[[Category: Eichinger, A]]
[[Category: Skerra, A]]