OCA at 13:46, 24 January 2024

OCA — Wed, 24 Jan 2024 13:46:46 GMT

←Older revision		Revision as of 13:46, 24 January 2024
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	==syk in complex with 57262_SYKB-AZ13344324-2==		==syk in complex with 57262_SYKB-AZ13344324-2==
-	<StructureSection load='6zcu' size='340' side='right'caption='[[6zcu]]' scene=''>	+	<StructureSection load='6zcu' size='340' side='right'caption='[[6zcu]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZCU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZCU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zcu OCA], [https://pdbe.org/6zcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zcu RCSB], [https://www.ebi.ac.uk/pdbsum/6zcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zcu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.73Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5JG:6-CHLORO-2-(2-FLUORO-4,5-DIMETHOXYPHENYL)-N-(PIPERIDIN-4-YLMETHYL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-AMINE'>5JG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zcu OCA], [https://pdbe.org/6zcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zcu RCSB], [https://www.ebi.ac.uk/pdbsum/6zcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zcu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KSYK_HUMAN KSYK_HUMAN] Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. Beside its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen.<ref>PMID:8657103</ref> <ref>PMID:9535867</ref> <ref>PMID:12456653</ref> <ref>PMID:12387735</ref> <ref>PMID:15388330</ref> <ref>PMID:19909739</ref>
		+
		+	==See Also==
		+	*[[Tyrosine kinase 3D structures\|Tyrosine kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Patel J]]		[[Category: Patel J]]
	[[Category: Read JA]]		[[Category: Read JA]]

OCA at 07:28, 25 June 2021

OCA — Fri, 25 Jun 2021 07:28:54 GMT

←Older revision		Revision as of 07:28, 25 June 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6zcu ~~is ON HOLD until Paper Publication~~	+	==syk in complex with 57262_SYKB-AZ13344324-2==
-		+	<StructureSection load='6zcu' size='340' side='right'caption='[[6zcu]]' scene=''>
-	~~Authors~~: ~~Read~~, J.A., ~~Patel~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZCU FirstGlance]. <br>
-	~~Description~~: ~~syk in complex with 57262_SYKB~~-~~AZ13344324-2~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zcu OCA], [https://pdbe.org/6zcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zcu RCSB], [https://www.ebi.ac.uk/pdbsum/6zcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zcu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Patel, J]]	+	__TOC__
-	[[Category: Read~~, J.A~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Patel J]]
		+	[[Category: Read JA]]

OCA at 07:54, 22 July 2020

OCA — Wed, 22 Jul 2020 07:54:01 GMT

←Older revision		Revision as of 07:54, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zcu is ON HOLD	+	The entry 6zcu is ON HOLD until Paper Publication

	Authors: Read, J.A., Patel, J.		Authors: Read, J.A., Patel, J.

OCA: Protected "6zcu" [edit=sysop:move=sysop]

OCA — Wed, 24 Jun 2020 18:35:51 GMT

Protected "6zcu" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:35, 24 June 2020

OCA: New page: '''Unreleased structure''' The entry 6zcu is ON HOLD Authors: Read, J.A., Patel, J. Description: syk in complex with 57262_SYKB-AZ13344324-2 Category: Unreleased Structures [[Categ...

OCA — Wed, 24 Jun 2020 18:35:49 GMT

New page: '''Unreleased structure''' The entry 6zcu is ON HOLD Authors: Read, J.A., Patel, J. Description: syk in complex with 57262_SYKB-AZ13344324-2 Category: Unreleased Structures [[Categ...

New page

'''Unreleased structure'''

The entry 6zcu is ON HOLD

Authors: Read, J.A., Patel, J.

Description: syk in complex with 57262_SYKB-AZ13344324-2
[[Category: Unreleased Structures]]
[[Category: Patel, J]]
[[Category: Read, J.A]]

6zcu - Revision history

OCA at 13:46, 24 January 2024

OCA at 07:28, 25 June 2021

OCA at 07:54, 22 July 2020

OCA: Protected "6zcu" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6zcu is ON HOLD Authors: Read, J.A., Patel, J. Description: syk in complex with 57262_SYKB-AZ13344324-2 Category: Unreleased Structures [[Categ...