OCA at 13:49, 24 January 2024

OCA — Wed, 24 Jan 2024 13:49:02 GMT

←Older revision		Revision as of 13:49, 24 January 2024
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	==glutamate transporter homologue Glttk in complex with a photo cage compound==		==glutamate transporter homologue Glttk in complex with a photo cage compound==
-	<StructureSection load='6zgb' size='340' side='right'caption='[[6zgb]]' scene=''>	+	<StructureSection load='6zgb' size='340' side='right'caption='[[6zgb]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZGB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zgb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZGB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zgb OCA], [https://pdbe.org/6zgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zgb RCSB], [https://www.ebi.ac.uk/pdbsum/6zgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zgb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=QJW:(2~{S},3~{S})-2-azanyl-3-[(2-nitrophenyl)methoxy]butanedioic+acid'>QJW</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zgb OCA], [https://pdbe.org/6zgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zgb RCSB], [https://www.ebi.ac.uk/pdbsum/6zgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zgb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5JID0_THEKO Q5JID0_THEKO]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Photopharmacology addresses the challenge of drug selectivity and side effects through creation of photoresponsive molecules activated with light with high spatiotemporal precision. This is achieved through incorporation of molecular photoswitches and photocages into the pharmacophore. However, the structural basis for the light-induced modulation of inhibitory potency in general is still missing, which poses a major design challenge for this emerging field of research. Here we solved crystal structures of the glutamate transporter homologue GltTk in complex with photoresponsive transport inhibitors-azobenzene derivative of TBOA (both in trans and cis configuration) and with the photocaged compound ONB-hydroxyaspartate. The essential role of glutamate transporters in the functioning of the central nervous system renders them potential therapeutic targets in the treatment of neurodegenerative diseases. The obtained structures provide a clear structural insight into the origins of photocontrol in photopharmacology and lay the foundation for application of photocontrolled ligands to study the transporter dynamics by using time-resolved X-ray crystallography.
		+
		+	Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue.,Arkhipova V, Fu H, Hoorens MWH, Trinco G, Lameijer LN, Marin E, Feringa BL, Poelarends GJ, Szymanski W, Slotboom DJ, Guskov A J Am Chem Soc. 2021 Jan 15. doi: 10.1021/jacs.0c11336. PMID:33449695<ref>PMID:33449695</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zgb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Symporter 3D structures\|Symporter 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Thermococcus kodakarensis KOD1]]
	[[Category: Arkhipova V]]		[[Category: Arkhipova V]]
	[[Category: Guskov A]]		[[Category: Guskov A]]
	[[Category: Slotboom DJ]]		[[Category: Slotboom DJ]]

OCA at 07:55, 27 January 2021

OCA — Wed, 27 Jan 2021 07:55:52 GMT

←Older revision		Revision as of 07:55, 27 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6zgb is ~~ON HOLD until Paper Publication~~	+	==glutamate transporter homologue Glttk in complex with a photo cage compound==
-		+	<StructureSection load='6zgb' size='340' side='right'caption='[[6zgb]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZGB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zgb OCA], [https://pdbe.org/6zgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zgb RCSB], [https://www.ebi.ac.uk/pdbsum/6zgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zgb ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arkhipova V]]
		+	[[Category: Guskov A]]
		+	[[Category: Slotboom DJ]]

OCA at 07:58, 22 July 2020

OCA — Wed, 22 Jul 2020 07:58:39 GMT

←Older revision		Revision as of 07:58, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zgb is ON HOLD	+	The entry 6zgb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6zgb" [edit=sysop:move=sysop]

OCA — Wed, 24 Jun 2020 18:47:26 GMT

Protected "6zgb" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:47, 24 June 2020

OCA: New page: '''Unreleased structure''' The entry 6zgb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Jun 2020 18:47:25 GMT

New page: '''Unreleased structure''' The entry 6zgb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zgb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6zgb - Revision history

OCA at 13:49, 24 January 2024

OCA at 07:55, 27 January 2021

OCA at 07:58, 22 July 2020

OCA: Protected "6zgb" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6zgb is ON HOLD Authors: Description: Category: Unreleased Structures