6zi0 - Revision history

OCA at 11:52, 1 February 2024

OCA — Thu, 01 Feb 2024 11:52:38 GMT

←Older revision		Revision as of 11:52, 1 February 2024
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	<StructureSection load='6zi0' size='340' side='right'caption='[[6zi0]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6zi0' size='340' side='right'caption='[[6zi0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zi0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Haei8 Haei8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZI0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ZI0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zi0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_86-028NP Haemophilus influenzae 86-028NP]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZI0 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~vapD~~, ~~NTHI0577 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=281310 HAEI8])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zi0 OCA], [~~http~~://pdbe.org/6zi0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zi0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zi0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zi0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zi0 OCA], [https://pdbe.org/6zi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zi0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zi0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q4QN95_HAEI8 Q4QN95_HAEI8]] Cleaves ssRNA, mostly between U:A.[PIRNR:PIRNR002882]	+	[https://www.uniprot.org/uniprot/Q4QN95_HAEI8 Q4QN95_HAEI8] Cleaves ssRNA, mostly between U:A.[PIRNR:PIRNR002882]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Haei8~~]]	+	[[Category: Haemophilus influenzae 86-028NP]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bertelsen~~, M B~~]]	+	[[Category: Bertelsen MB]]
-	[[Category: Bisiak, F]]	+	[[Category: Bisiak F]]
-	[[Category: Brodersen~~, D E~~]]	+	[[Category: Brodersen DE]]
-	[[Category: Cunha~~, M V~~]]	+	[[Category: Cunha MV]]
-	[[Category: Daines~~, D A~~]]	+	[[Category: Daines DA]]
-	[[Category: Molinaro~~, A L~~]]	+	[[Category: Molinaro AL]]
-	[[Category: Nielsen~~, M H~~]]	+	[[Category: Nielsen MH]]
-	[[Category: Senissar, M]]	+	[[Category: Senissar M]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nucleic-acid binding protein]]~~	+
-	~~[[Category: Rnase]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Toxin-antitoxin]]~~	+
-	~~[[Category: Vapxd~~]]	+

OCA at 07:39, 4 November 2020

OCA — Wed, 04 Nov 2020 07:39:24 GMT

←Older revision		Revision as of 07:39, 4 November 2020
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	==Crystal structure of the isolated H. influenzae VapD toxin (wildtype)==		==Crystal structure of the isolated H. influenzae VapD toxin (wildtype)==
-	<StructureSection load='6zi0' size='340' side='right'caption='[[6zi0]]' scene=''>	+	<StructureSection load='6zi0' size='340' side='right'caption='[[6zi0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZI0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZI0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zi0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haei8 Haei8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZI0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZI0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zi0 OCA], [http://pdbe.org/6zi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zi0 RCSB], [http://www.ebi.ac.uk/pdbsum/6zi0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zi0 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vapD, NTHI0577 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=281310 HAEI8])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zi0 OCA], [http://pdbe.org/6zi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zi0 RCSB], [http://www.ebi.ac.uk/pdbsum/6zi0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zi0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q4QN95_HAEI8 Q4QN95_HAEI8]] Cleaves ssRNA, mostly between U:A.[PIRNR:PIRNR002882]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial type II toxin-antitoxin (TA) modules encode a toxic protein that downregulates metabolism and a specific antitoxin that binds and inhibits the toxin during normal growth. In non-typeable Haemophilus influenzae, a common cause of infections in humans, the vapXD locus was found to constitute a functional TA module and contribute to pathogenicity; however, the mode of action of VapD and the mechanism of inhibition by the VapX antitoxin remain unknown. Here, we report the structure of the intact H. influenzae VapXD complex, revealing an unusual 2:1 TA molecular stoichiometry where a Cas2-like homodimer of VapD binds a single VapX antitoxin. VapX consists of an oligonucleotide/oligosaccharide-binding domain that docks into an asymmetrical cavity on the toxin dimer. Structures of isolated VapD further reveal how a symmetrical toxin homodimer adapts to interacting with an asymmetrical antitoxin and suggest how a primordial TA system evolved to become part of CRISPR-Cas immunity systems.
		+
		+	Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System.,Bertelsen MB, Senissar M, Nielsen MH, Bisiak F, Cunha MV, Molinaro AL, Daines DA, Brodersen DE Structure. 2020 Oct 16. pii: S0969-2126(20)30373-7. doi:, 10.1016/j.str.2020.10.002. PMID:33096014<ref>PMID:33096014</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zi0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Haei8]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bertelsen MB]]	+	[[Category: Bertelsen, M B]]
-	[[Category: Bisiak F]]	+	[[Category: Bisiak, F]]
-	[[Category: Brodersen DE]]	+	[[Category: Brodersen, D E]]
-	[[Category: Cunha MV]]	+	[[Category: Cunha, M V]]
-	[[Category: Daines DA]]	+	[[Category: Daines, D A]]
-	[[Category: Molinaro AL]]	+	[[Category: Molinaro, A L]]
-	[[Category: Nielsen MH]]	+	[[Category: Nielsen, M H]]
-	[[Category: Senissar M]]	+	[[Category: Senissar, M]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nucleic-acid binding protein]]
		+	[[Category: Rnase]]
		+	[[Category: Toxin]]
		+	[[Category: Toxin-antitoxin]]
		+	[[Category: Vapxd]]

OCA at 05:50, 14 October 2020

OCA — Wed, 14 Oct 2020 05:50:51 GMT

←Older revision		Revision as of 05:50, 14 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6zi0 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the isolated H. influenzae VapD toxin (wildtype)==
-		+	<StructureSection load='6zi0' size='340' side='right'caption='[[6zi0]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZI0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZI0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zi0 OCA], [http://pdbe.org/6zi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zi0 RCSB], [http://www.ebi.ac.uk/pdbsum/6zi0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zi0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bertelsen MB]]
		+	[[Category: Bisiak F]]
		+	[[Category: Brodersen DE]]
		+	[[Category: Cunha MV]]
		+	[[Category: Daines DA]]
		+	[[Category: Molinaro AL]]
		+	[[Category: Nielsen MH]]
		+	[[Category: Senissar M]]

OCA at 09:28, 29 July 2020

OCA — Wed, 29 Jul 2020 09:28:33 GMT

←Older revision		Revision as of 09:28, 29 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zi0 is ON HOLD	+	The entry 6zi0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6zi0" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:10:26 GMT

Protected "6zi0" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:10, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zi0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 11:10:25 GMT

New page: '''Unreleased structure''' The entry 6zi0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zi0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]