6zj9 - Revision history

OCA at 11:53, 1 February 2024

OCA — Thu, 01 Feb 2024 11:53:20 GMT

←Older revision		Revision as of 11:53, 1 February 2024
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	<StructureSection load='6zj9' size='340' side='right'caption='[[6zj9]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6zj9' size='340' side='right'caption='[[6zj9]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zj9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZJ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ZJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZJ9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GSTA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9796 Equus caballus])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zj9 OCA], [https://pdbe.org/6zj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zj9 RCSB], [https://www.ebi.ac.uk/pdbsum/6zj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zj9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zj9 OCA], [~~http~~://pdbe.org/6zj9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zj9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zj9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zj9 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M9ZT87_HORSE M9ZT87_HORSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6zj9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6zj9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
-	[[Category: Glutathione transferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ismail, A]]	+	[[Category: Ismail A]]
-	[[Category: Lindstrom, H]]	+	[[Category: Lindstrom H]]
-	[[Category: Mannervik, B]]	+	[[Category: Mannervik B]]
-	[[Category: Sjodin, B]]	+	[[Category: Sjodin B]]
-	[[Category: Skerlova, J]]	+	[[Category: Skerlova J]]
-	[[Category: Stenmark, P]]	+	[[Category: Stenmark P]]
-	~~[[Category: Detoxication]]~~	+
-	~~[[Category: Hormone biosynthesis]]~~	+
-	~~[[Category: Steroid isomerase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:01, 24 December 2020

OCA — Thu, 24 Dec 2020 11:01:31 GMT

←Older revision		Revision as of 11:01, 24 December 2020
Line 1:		Line 1:

	==Crystal structure of Equus ferus caballus glutathione transferase A3-3 in complex with glutathione==		==Crystal structure of Equus ferus caballus glutathione transferase A3-3 in complex with glutathione==
-	<StructureSection load='6zj9' size='340' side='right'caption='[[6zj9]]' scene=''>	+	<StructureSection load='6zj9' size='340' side='right'caption='[[6zj9]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZJ9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zj9 OCA], [http://pdbe.org/6zj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zj9 RCSB], [http://www.ebi.ac.uk/pdbsum/6zj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zj9 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9796 Equus caballus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zj9 OCA], [http://pdbe.org/6zj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zj9 RCSB], [http://www.ebi.ac.uk/pdbsum/6zj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zj9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Organotin compounds are highly toxic environmental pollutants with neurotoxic and endocrine-disrupting effects. They are potent inhibitors of glutathione transferases (GSTs), thus impeding their detoxication and antioxidant functions. Several GSTs, including equine GST A3-3 (EcaGST A3-3), exhibit steroid double-bond isomerase activity and are involved in the biosynthesis of testosterone and progesterone. We have performed enzyme kinetics analyses of the inhibition of EcaGST A3-3 by organotin compounds. We have also solved crystal structures of EcaGST A3-3 in complexes with glutathione, and with glutathione together with covalently bound triethyltin. Our structural data indicate that the tin atom forms strong bonds with a covalent character not only with the glutathione, but also with a tyrosyl residue of the enzyme itself, thereby preventing the release of the glutathione-organotin adduct and completely blocking the enzyme function. This work presents a structural basis for the general mechanism of GST inhibition by organotin compounds and contributes to the understanding of their neurotoxic and endocrine disrupting effects.
		+
		+	Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants.,Skerlova J, Ismail A, Lindstrom H, Sjodin B, Mannervik B, Stenmark P Environ Pollut. 2020 Oct 29:115960. doi: 10.1016/j.envpol.2020.115960. PMID:33162212<ref>PMID:33162212</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zj9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Equus caballus]]
		+	[[Category: Glutathione transferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ismail A]]	+	[[Category: Ismail, A]]
-	[[Category: Lindstrom H]]	+	[[Category: Lindstrom, H]]
-	[[Category: Mannervik B]]	+	[[Category: Mannervik, B]]
-	[[Category: Sjodin B]]	+	[[Category: Sjodin, B]]
-	[[Category: Skerlova J]]	+	[[Category: Skerlova, J]]
-	[[Category: Stenmark P]]	+	[[Category: Stenmark, P]]
		+	[[Category: Detoxication]]
		+	[[Category: Hormone biosynthesis]]
		+	[[Category: Steroid isomerase]]
		+	[[Category: Transferase]]

OCA at 09:39, 18 November 2020

OCA — Wed, 18 Nov 2020 09:39:24 GMT

←Older revision		Revision as of 09:39, 18 November 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6zj9 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Equus ferus caballus glutathione transferase A3-3 in complex with glutathione==
-		+	<StructureSection load='6zj9' size='340' side='right'caption='[[6zj9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZJ9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zj9 OCA], [http://pdbe.org/6zj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zj9 RCSB], [http://www.ebi.ac.uk/pdbsum/6zj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zj9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ismail A]]
		+	[[Category: Lindstrom H]]
		+	[[Category: Mannervik B]]
		+	[[Category: Sjodin B]]
		+	[[Category: Skerlova J]]
		+	[[Category: Stenmark P]]

OCA: Protected "6zj9" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:13:18 GMT

Protected "6zj9" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:13, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zj9 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 11:13:17 GMT

New page: '''Unreleased structure''' The entry 6zj9 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zj9 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]