6zky - Revision history

OCA at 11:53, 1 February 2024

OCA — Thu, 01 Feb 2024 11:53:56 GMT

←Older revision		Revision as of 11:53, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6zky]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZKY FirstGlance]. <br>		<table><tr><td colspan='2'>[[6zky]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZKY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMB:5-Mercapto-norvaline'>QMB</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMB:5-Mercapto-norvaline'>QMB</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zky OCA], [https://pdbe.org/6zky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zky RCSB], [https://www.ebi.ac.uk/pdbsum/6zky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zky ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zky OCA], [https://pdbe.org/6zky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zky RCSB], [https://www.ebi.ac.uk/pdbsum/6zky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zky ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 6zky" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6zky" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
		+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:27, 7 December 2022

OCA — Wed, 07 Dec 2022 08:27:59 GMT

←Older revision		Revision as of 08:27, 7 December 2022
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-	====	+	==Crystal structure of InhA:01 TCR in complex with HLA-E (S147C) bound to InhA (53-61 H3C)==
-	<StructureSection load='6zky' size='340' side='right'caption='[[6zky]]' scene=''>	+	<StructureSection load='6zky' size='340' side='right'caption='[[6zky]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zky]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZKY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zky OCA], [https://pdbe.org/6zky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zky RCSB], [https://www.ebi.ac.uk/pdbsum/6zky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zky ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMB:5-Mercapto-norvaline'>QMB</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zky OCA], [https://pdbe.org/6zky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zky RCSB], [https://www.ebi.ac.uk/pdbsum/6zky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zky ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HLAE_HUMAN HLAE_HUMAN] Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nonpolymorphic class Ib molecule, HLA-E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. Although peptides of pathogenic origin can also be presented by HLA-E to T cells, the molecular basis underpinning their role in antigen surveillance is largely unknown. Here, we solved a co-complex crystal structure of a TCR with an HLA-E presented peptide (pHLA-E) from bacterial (Mycobacterium tuberculosis) origin, and the first TCR-pHLA-E complex with a noncanonically presented peptide from viral (HIV) origin. The structures provided a molecular foundation to develop a novel method to introduce cysteine traps using non-natural amino acid chemistry that stabilized pHLA-E complexes while maintaining native interface contacts between the TCRs and different pHLA-E complexes. These pHLA-E monomers could be used to isolate pHLA-E-specific T cells, with obvious utility for studying pHLA-E restricted T cells, and for the identification of putative therapeutic TCRs.
		+
		+	Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.,Barber C, De Souza VA, Paterson RL, Martin-Urdiroz M, Mulakkal NC, Srikannathasan V, Connolly M, Phillips G, Foong-Leong T, Pengelly R, Karuppiah V, Grant T, Dembek M, Verma A, Gibbs-Howe D, Blicher TH, Knox A, Robinson RA, Cole DK, Leonard S Eur J Immunol. 2022 Apr;52(4):618-632. doi: 10.1002/eji.202149745. Epub 2022 Feb , 13. PMID:35108401<ref>PMID:35108401</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zky" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
		+	[[Category: Karuppiah V]]
		+	[[Category: Robinson RA]]
		+	[[Category: Srikannathasan V]]

OCA at 06:59, 27 January 2022

OCA — Thu, 27 Jan 2022 06:59:40 GMT

←Older revision		Revision as of 06:59, 27 January 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 6zky ~~is ON HOLD~~	+	====
-		+	<StructureSection load='6zky' size='340' side='right'caption='[[6zky]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zky OCA], [https://pdbe.org/6zky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zky RCSB], [https://www.ebi.ac.uk/pdbsum/6zky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zky ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 15:26, 15 December 2021

OCA — Wed, 15 Dec 2021 15:26:36 GMT

←Older revision		Revision as of 15:26, 15 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zky is ON HOLD ~~until Paper Publication~~	+	The entry 6zky is ON HOLD

	Authors:		Authors:

OCA at 09:30, 29 July 2020

OCA — Wed, 29 Jul 2020 09:30:54 GMT

←Older revision		Revision as of 09:30, 29 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zky is ON HOLD	+	The entry 6zky is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6zky" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:17:03 GMT

Protected "6zky" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:17, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zky is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 11:17:01 GMT

New page: '''Unreleased structure''' The entry 6zky is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zky is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]