6zl9 - Revision history

OCA at 11:08, 14 June 2023

OCA — Wed, 14 Jun 2023 11:08:59 GMT

←Older revision		Revision as of 11:08, 14 June 2023
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	==Structure of a parallel c-Myc modified with 5' duplex stem-loop overhang==		==Structure of a parallel c-Myc modified with 5' duplex stem-loop overhang==
-	<StructureSection load='6zl9' size='340' side='right'caption='[[6zl9~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6zl9' size='340' side='right'caption='[[6zl9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zl9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZL9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ZL9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZL9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zl9 OCA], [~~http~~://pdbe.org/6zl9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zl9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zl9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zl9 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zl9 OCA], [https://pdbe.org/6zl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zl9 RCSB], [https://www.ebi.ac.uk/pdbsum/6zl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zl9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Vianney, Y M~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Weisz, K~~]]	+	[[Category: Vianney YM]]
-	[[Category: ~~Dna]]~~	+	[[Category: Weisz K]]
-	~~[[Category: Duplex]]~~	+
-	~~[[Category: G-quadruplex]]~~	+
-	~~[[Category: Quadruplex-duplex junction~~]]	+

OCA at 11:01, 24 December 2020

OCA — Thu, 24 Dec 2020 11:01:55 GMT

←Older revision		Revision as of 11:01, 24 December 2020
Line 1:		Line 1:

	==Structure of a parallel c-Myc modified with 5' duplex stem-loop overhang==		==Structure of a parallel c-Myc modified with 5' duplex stem-loop overhang==
-	<StructureSection load='6zl9' size='340' side='right'caption='[[6zl9]]' scene=''>	+	<StructureSection load='6zl9' size='340' side='right'caption='[[6zl9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZL9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZL9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zl9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZL9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZL9 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zl9 OCA], [http://pdbe.org/6zl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zl9 RCSB], [http://www.ebi.ac.uk/pdbsum/6zl9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zl9 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zl9 OCA], [http://pdbe.org/6zl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zl9 RCSB], [http://www.ebi.ac.uk/pdbsum/6zl9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zl9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A parallel quadruplex derived from the Myc promoter sequence was extended by a stem-loop duplex at either its 5'- or 3'-terminus to mimic a quadruplex-duplex (Q-D) junction as a potential genomic target. High-resolution structures of the hybrids demonstrate continuous stacking of the duplex on the quadruplex core without significant perturbations. An indoloquinoline ligand carrying an aminoalkyl sidechain was shown to bind the Q-D hybrids with a very high affinity in the order K a ~ 10 7 M -1 irrespective of the duplex location at the quadruplex 3'- or 5'-end. NMR chemical shift perturbations identified the tetrad face of the Q-D junction as specific binding site for the ligand. However, calorimetric analyses revealed significant differences in the thermodynamic profiles upon binding to hybrids with either a duplex extension at the quadruplex 3'- or 5'-terminus. A large enthalpic gain and considerable hydrophobic effects are accompanied by the binding of one ligand to the 3'-Q-D junction, whereas non-hydrophobic entropic contributions favor binding with formation of a 2:1 ligand-quadruplex complex in case of the 5'-Q-D hybrid.
		+
		+	Quadruplex-Duplex Junction: A High-Affinity Binding Site for Indoloquinoline Ligands.,Vianney YM, Preckwinkel P, Mohr S, Weisz K Chemistry. 2020 Sep 25. doi: 10.1002/chem.202003540. PMID:32975874<ref>PMID:32975874</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zl9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Vianney YM]]	+	[[Category: Vianney, Y M]]
-	[[Category: Weisz K]]	+	[[Category: Weisz, K]]
		+	[[Category: Dna]]
		+	[[Category: Duplex]]
		+	[[Category: G-quadruplex]]
		+	[[Category: Quadruplex-duplex junction]]

OCA at 06:21, 7 October 2020

OCA — Wed, 07 Oct 2020 06:21:48 GMT

←Older revision		Revision as of 06:21, 7 October 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6zl9 ~~is ON HOLD until Paper Publication~~	+	==Structure of a parallel c-Myc modified with 5' duplex stem-loop overhang==
-		+	<StructureSection load='6zl9' size='340' side='right'caption='[[6zl9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZL9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZL9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zl9 OCA], [http://pdbe.org/6zl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zl9 RCSB], [http://www.ebi.ac.uk/pdbsum/6zl9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zl9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Vianney YM]]
		+	[[Category: Weisz K]]

OCA: Protected "6zl9" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:17:35 GMT

Protected "6zl9" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:17, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zl9 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 11:17:34 GMT

New page: '''Unreleased structure''' The entry 6zl9 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zl9 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]