6zm5 - Revision history

OCA at 10:54, 15 November 2023

OCA — Wed, 15 Nov 2023 10:54:00 GMT

←Older revision		Revision as of 10:54, 15 November 2023
Line 1:		Line 1:

-	====	+	==Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide==
-	<StructureSection load='6zm5' size='340' side='right'caption='[[6zm5]]' scene=''>	+	<StructureSection load='6zm5' size='340' side='right'caption='[[6zm5]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zm5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZM5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm5 OCA], [https://pdbe.org/6zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/6zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.89Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=AYA:N-ACETYLALANINE'>AYA</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm5 OCA], [https://pdbe.org/6zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/6zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RM19_HUMAN RM19_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane to facilitate the cotranslational membrane insertion of the synthesized proteins. We report cryo-electron microscopy structures of human mitoribosomes with nascent polypeptide, bound to the insertase oxidase assembly 1-like (OXA1L) through three distinct contact sites. OXA1L binding is correlated with a series of conformational changes in the mitoribosomal large subunit that catalyze the delivery of newly synthesized polypeptides. The mechanism relies on the folding of mL45 inside the exit tunnel, forming two specific constriction sites that would limit helix formation of the nascent chain. A gap is formed between the exit and the membrane, making the newly synthesized proteins accessible. Our data elucidate the basis by which mitoribosomes interact with the OXA1L insertase to couple protein synthesis and membrane delivery.
		+
		+	Mechanism of membrane-tethered mitochondrial protein synthesis.,Itoh Y, Andrell J, Choi A, Richter U, Maiti P, Best RB, Barrientos A, Battersby BJ, Amunts A Science. 2021 Feb 19;371(6531):846-849. doi: 10.1126/science.abe0763. PMID:33602856<ref>PMID:33602856</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zm5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Amunts A]]
		+	[[Category: Andrell J]]
		+	[[Category: Itoh Y]]

OCA at 14:59, 3 March 2021

OCA — Wed, 03 Mar 2021 14:59:46 GMT

←Older revision		Revision as of 14:59, 3 March 2021
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	<StructureSection load='6zm5' size='340' side='right'caption='[[6zm5]]' scene=''>		<StructureSection load='6zm5' size='340' side='right'caption='[[6zm5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm5 OCA], [~~http~~://pdbe.org/6zm5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zm5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zm5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm5 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm5 OCA], [https://pdbe.org/6zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/6zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm5 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 05:52, 20 January 2021

OCA — Wed, 20 Jan 2021 05:52:03 GMT

←Older revision		Revision as of 05:52, 20 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6zm5 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6zm5' size='340' side='right'caption='[[6zm5]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm5 OCA], [http://pdbe.org/6zm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zm5 RCSB], [http://www.ebi.ac.uk/pdbsum/6zm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm5 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:29, 21 October 2020

OCA — Wed, 21 Oct 2020 06:29:11 GMT

←Older revision		Revision as of 06:29, 21 October 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zm5 is ON HOLD	+	The entry 6zm5 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6zm5" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:19:55 GMT

Protected "6zm5" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:19, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zm5 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 11:19:53 GMT

New page: '''Unreleased structure''' The entry 6zm5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zm5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]