6zmm - Revision history

OCA at 11:54, 1 February 2024

OCA — Thu, 01 Feb 2024 11:54:39 GMT

←Older revision		Revision as of 11:54, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='6zmm' size='340' side='right'caption='[[6zmm]], [[Resolution\|resolution]] 2.96Å' scene=''>		<StructureSection load='6zmm' size='340' side='right'caption='[[6zmm]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zmm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zmm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.96Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NDRG1, CAP43, DRG1, RTP ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmm OCA], [https://pdbe.org/6zmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmm RCSB], [https://www.ebi.ac.uk/pdbsum/6zmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmm OCA], [https://pdbe.org/6zmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmm RCSB], [https://www.ebi.ac.uk/pdbsum/6zmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmm ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN]] Charcot-Marie-Tooth disease type 4D. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN] Charcot-Marie-Tooth disease type 4D. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN]] Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.<ref>PMID:15247272</ref> <ref>PMID:15377670</ref> <ref>PMID:17786215</ref> <ref>PMID:9766676</ref>	+	[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN] Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.<ref>PMID:15247272</ref> <ref>PMID:15377670</ref> <ref>PMID:17786215</ref> <ref>PMID:9766676</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kursula, P]]	+	[[Category: Kursula P]]
-	[[Category: Mustonen, V]]	+	[[Category: Mustonen V]]
-	[[Category: Ruskamo, S]]	+	[[Category: Ruskamo S]]
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Tumor suppressor~~]]	+

OCA at 14:54, 17 June 2021

OCA — Thu, 17 Jun 2021 14:54:13 GMT

←Older revision		Revision as of 14:54, 17 June 2021
Line 1:		Line 1:

	==Crystal structure of human NDRG1==		==Crystal structure of human NDRG1==
-	<StructureSection load='6zmm' size='340' side='right'caption='[[6zmm]]' scene=''>	+	<StructureSection load='6zmm' size='340' side='right'caption='[[6zmm]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ZMM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zmm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6zmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmm OCA], [~~http~~://pdbe.org/6zmm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6zmm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6zmm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmm ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDRG1, CAP43, DRG1, RTP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmm OCA], [https://pdbe.org/6zmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmm RCSB], [https://www.ebi.ac.uk/pdbsum/6zmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN]] Charcot-Marie-Tooth disease type 4D. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN]] Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.<ref>PMID:15247272</ref> <ref>PMID:15377670</ref> <ref>PMID:17786215</ref> <ref>PMID:9766676</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-myc downstream regulated gene 1 (NDRG1) is a tumour suppressor involved in vesicular trafficking and stress response. NDRG1 participates in peripheral nerve myelination, and mutations in the NDRG1 gene lead to Charcot-Marie-Tooth neuropathy. The 43-kDa NDRG1 is considered as an inactive member of the alpha/beta hydrolase superfamily. In addition to a central alpha/beta hydrolase fold domain, NDRG1 consists of a short N terminus and a C-terminal region with three 10-residue repeats. We determined the crystal structure of the alpha/beta hydrolase domain of human NDRG1 and characterised the structure and dynamics of full-length NDRG1. The structure of the alpha/beta hydrolase domain resembles the canonical alpha/beta hydrolase fold with a central beta sheet surrounded by alpha helices. Small-angle X-ray scattering and CD spectroscopy indicated a variable conformation for the N- and C-terminal regions. NDRG1 binds to various types of lipid vesicles, and the conformation of the C-terminal region is modulated upon lipid interaction. Intriguingly, NDRG1 interacts with metal ions, such as nickel, but is prone to aggregation in their presence. Our results uncover the structural and dynamic features of NDRG1, as well as elucidate its interactions with metals and lipids, and encourage studies to identify a putative hydrolase activity of NDRG1.
		+
		+	Crystal and solution structure of NDRG1, a membrane-binding protein linked to myelination and tumour suppression.,Mustonen V, Muruganandam G, Loris R, Kursula P, Ruskamo S FEBS J. 2020 Dec 10. doi: 10.1111/febs.15660. PMID:33305529<ref>PMID:33305529</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zmm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kursula P]]	+	[[Category: Kursula, P]]
-	[[Category: Mustonen V]]	+	[[Category: Mustonen, V]]
-	[[Category: Ruskamo S]]	+	[[Category: Ruskamo, S]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Tumor suppressor]]

OCA at 10:34, 24 December 2020

OCA — Thu, 24 Dec 2020 10:34:56 GMT

←Older revision		Revision as of 10:34, 24 December 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6zmm is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human NDRG1==
-		+	<StructureSection load='6zmm' size='340' side='right'caption='[[6zmm]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ZMM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmm OCA], [http://pdbe.org/6zmm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zmm RCSB], [http://www.ebi.ac.uk/pdbsum/6zmm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmm ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kursula P]]
		+	[[Category: Mustonen V]]
		+	[[Category: Ruskamo S]]

OCA at 03:55, 5 August 2020

OCA — Wed, 05 Aug 2020 03:55:38 GMT

←Older revision		Revision as of 03:55, 5 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zmm is ON HOLD	+	The entry 6zmm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6zmm" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:21:15 GMT

Protected "6zmm" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:21, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zmm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 11:21:14 GMT

New page: '''Unreleased structure''' The entry 6zmm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zmm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]