OCA at 11:56, 1 February 2024

OCA — Thu, 01 Feb 2024 11:56:23 GMT

←Older revision		Revision as of 11:56, 1 February 2024
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-	====	+	==HER2-binding scFv-Fab fusion 841==
-	<StructureSection load='6zqk' size='340' side='right'caption='[[6zqk]]' scene=''>	+	<StructureSection load='6zqk' size='340' side='right'caption='[[6zqk]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zqk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZQK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zqk OCA], [https://pdbe.org/6zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zqk RCSB], [https://www.ebi.ac.uk/pdbsum/6zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zqk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zqk OCA], [https://pdbe.org/6zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zqk RCSB], [https://www.ebi.ac.uk/pdbsum/6zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zqk ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The receptor tyrosine kinase HER2 acts as oncogenic driver in numerous cancers. Usually, the gene is amplified, resulting in receptor overexpression, massively increased signaling and unchecked proliferation. However, tumors become frequently addicted to oncogenes and hence are druggable by targeted interventions. Here, we design an anti-HER2 biparatopic and tetravalent IgG fusion with a multimodal mechanism of action. The molecule first induces HER2 clustering into inactive complexes, evidenced by reduced mobility of surface HER2. However, in contrast to our earlier binders based on DARPins, clusters of HER2 are thereafter robustly internalized and quantitatively degraded. This multimodal mechanism of action is found only in few of the tetravalent constructs investigated, which must target specific epitopes on HER2 in a defined geometric arrangement. The inhibitory effect of our antibody as single agent surpasses the combination of trastuzumab and pertuzumab as well as its parental mAbs in vitro and it is effective in a xenograft model.
		+
		+	Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.,Kast F, Schwill M, Stuber JC, Pfundstein S, Nagy-Davidescu G, Rodriguez JMM, Seehusen F, Richter CP, Honegger A, Hartmann KP, Weber TG, Kroener F, Ernst P, Piehler J, Pluckthun A Nat Commun. 2021 Jun 18;12(1):3790. doi: 10.1038/s41467-021-23948-6. PMID:34145240<ref>PMID:34145240</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zqk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Ernst P]]
		+	[[Category: Hartmann KP]]
		+	[[Category: Honegger A]]
		+	[[Category: Kast F]]
		+	[[Category: Kroener F]]
		+	[[Category: Monne Rodriguez JM]]
		+	[[Category: Nagy-Davidescu G]]
		+	[[Category: Pfundstein S]]
		+	[[Category: Piehler J]]
		+	[[Category: Plueckthun A]]
		+	[[Category: Richter CP]]
		+	[[Category: Schwill M]]
		+	[[Category: Seehusen F]]
		+	[[Category: Stueber JC]]
		+	[[Category: Weber TG]]

OCA at 03:31, 2 July 2021

OCA — Fri, 02 Jul 2021 03:31:36 GMT

←Older revision		Revision as of 03:31, 2 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6zqk ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6zqk' size='340' side='right'caption='[[6zqk]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zqk OCA], [https://pdbe.org/6zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zqk RCSB], [https://www.ebi.ac.uk/pdbsum/6zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zqk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 08:11, 12 August 2020

OCA — Wed, 12 Aug 2020 08:11:31 GMT

←Older revision		Revision as of 08:11, 12 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zqk is ON HOLD	+	The entry 6zqk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6zqk" [edit=sysop:move=sysop]

OCA — Wed, 22 Jul 2020 08:13:14 GMT

Protected "6zqk" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:13, 22 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zqk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Jul 2020 08:13:12 GMT

New page: '''Unreleased structure''' The entry 6zqk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zqk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6zqk - Revision history

OCA at 11:56, 1 February 2024

OCA at 03:31, 2 July 2021

OCA at 08:11, 12 August 2020

OCA: Protected "6zqk" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6zqk is ON HOLD Authors: Description: Category: Unreleased Structures