6ztf - Revision history

OCA at 11:58, 1 February 2024

OCA — Thu, 01 Feb 2024 11:58:12 GMT

←Older revision		Revision as of 11:58, 1 February 2024
Line 1:		Line 1:

-	====	+	==Crystal Structure of the anti-human P-Cadherin Fab CQY684==
-	<StructureSection load='6ztf' size='340' side='right'caption='[[6ztf]]' scene=''>	+	<StructureSection load='6ztf' size='340' side='right'caption='[[6ztf]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ztf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZTF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ztf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ztf OCA], [https://pdbe.org/6ztf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ztf RCSB], [https://www.ebi.ac.uk/pdbsum/6ztf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ztf ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ztf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ztf OCA], [https://pdbe.org/6ztf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ztf RCSB], [https://www.ebi.ac.uk/pdbsum/6ztf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ztf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cell surface glycoprotein P-cadherin (PCAD) is highly expressed in a number of malignancies, including those arising in the epithelium of the bladder, breast, esophagus, lung and upper aerodigestive system. PCA062 is a P-cadherin specific antibody drug conjugate (ADC) that utilizes the clinically validated SMCC-DM1 linker-payload to mediate potent cytotoxicity in cell lines expressing high levels of P-cadherin in vitro, while displaying no specific activity in P-cadherin negative cell lines. High cell surface P-cadherin is necessary, but not sufficient, to mediate PCA062 cytotoxicity. In vivo, PCA062 demonstrated high serum stability and a potent ability to induce mitotic arrest. In addition, PCA062 was efficacious in clinically relevant models of P-cadherin expressing cancers, including breast, esophageal and head and neck. Preclinical non-human primate toxicology studies demonstrated a favorable safety profile that supports clinical development. Genome-wide CRISPR screens reveal that expression of the multi-drug resistant gene ABCC1 and the lysosomal transporter SLC46A3 differentially impact tumor cell sensitivity to PCA062. The preclinical data presented here suggest that PCA062 may have clinical value for treating patients with multiple cancer types including basal-like breast cancer.
		+
		+	PCA062, a P-cadherin targeting antibody-drug-conjugate, displays potent anti-tumor activity against P-cadherin-expressing malignancies.,Sheng Q, D'Alessio JA, Menezes DL, Karim C, Tang Y, Tam A, Clark S, Ying C, Connor A, Mansfield KG, Rondeau JM, Ghoddusi M, Geyer FC, Gu J, McLaughlin ME, Newcombe R, Elliott G, Tschantz WR, Lehmann S, Miller K, Huber T, Rendahl KG, Jeffry U, Pryer NK, Lees E, Kwon P, Abraham JA, Damiano JS, Abrams TJ Mol Cancer Ther. 2021 Apr 20. pii: 1535-7163.MCT-20-0708. doi:, 10.1158/1535-7163.MCT-20-0708. PMID:33879555<ref>PMID:33879555</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ztf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Lehmann S]]
		+	[[Category: Rondeau JM]]

OCA at 08:51, 5 May 2021

OCA — Wed, 05 May 2021 08:51:51 GMT

←Older revision		Revision as of 08:51, 5 May 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ztf ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6ztf' size='340' side='right'caption='[[6ztf]]' scene=''>
-	~~Authors~~: ~~Rondeau, J~~.M.~~, Lehmann, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of the anti~~-~~human P-Cadherin Fab CQY684~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ztf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ztf OCA], [https://pdbe.org/6ztf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ztf RCSB], [https://www.ebi.ac.uk/pdbsum/6ztf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ztf ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Lehmann, S~~]]	+	__TOC__
-	[[Category: ~~Rondeau, J.M~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:08, 26 August 2020

OCA — Wed, 26 Aug 2020 09:08:35 GMT

←Older revision		Revision as of 09:08, 26 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ztf is ON HOLD	+	The entry 6ztf is ON HOLD until Paper Publication

	Authors: Rondeau, J.M., Lehmann, S.		Authors: Rondeau, J.M., Lehmann, S.

OCA: Protected "6ztf" [edit=sysop:move=sysop]

OCA — Wed, 29 Jul 2020 09:33:46 GMT

Protected "6ztf" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 29 July 2020

OCA: New page: '''Unreleased structure''' The entry 6ztf is ON HOLD Authors: Rondeau, J.M., Lehmann, S. Description: Crystal Structure of the anti-human P-Cadherin Fab CQY684 [[Category: Unreleased S...

OCA — Wed, 29 Jul 2020 09:33:44 GMT

New page: '''Unreleased structure''' The entry 6ztf is ON HOLD Authors: Rondeau, J.M., Lehmann, S. Description: Crystal Structure of the anti-human P-Cadherin Fab CQY684 [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 6ztf is ON HOLD

Authors: Rondeau, J.M., Lehmann, S.

Description: Crystal Structure of the anti-human P-Cadherin Fab CQY684
[[Category: Unreleased Structures]]
[[Category: Lehmann, S]]
[[Category: Rondeau, J.M]]