6zv4 - Revision history

OCA at 11:09, 14 June 2023

OCA — Wed, 14 Jun 2023 11:09:17 GMT

←Older revision		Revision as of 11:09, 14 June 2023
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	==Human TFIIS N-terminal domain in complex with IWS1==		==Human TFIIS N-terminal domain in complex with IWS1==
-	<StructureSection load='6zv4' size='340' side='right'caption='[[6zv4~~]], [[NMR_Ensembles_of_Models \| 40 NMR models~~]]' scene=''>	+	<StructureSection load='6zv4' size='340' side='right'caption='[[6zv4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.	+	[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.	+	[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.[https://www.uniprot.org/uniprot/IWS1_HUMAN IWS1_HUMAN] Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.<ref>PMID:17184735</ref> <ref>PMID:17234882</ref> <ref>PMID:19141475</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Veverka, V]]	+	[[Category: Veverka V]]
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription elongation~~]]	+

OCA at 10:01, 8 December 2021

OCA — Wed, 08 Dec 2021 10:01:59 GMT

←Older revision		Revision as of 10:01, 8 December 2021
Line 1:		Line 1:

	==Human TFIIS N-terminal domain in complex with IWS1==		==Human TFIIS N-terminal domain in complex with IWS1==
-	<StructureSection load='6zv4' size='340' side='right'caption='[[6zv4]]' scene=''>	+	<StructureSection load='6zv4' size='340' side='right'caption='[[6zv4]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	[Figure: see text].
		+
		+	A ubiquitous disordered protein interaction module orchestrates transcription elongation.,Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V Science. 2021 Nov 26;374(6571):1113-1121. doi: 10.1126/science.abe2913. Epub 2021, Nov 25. PMID:34822292<ref>PMID:34822292</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zv4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Veverka V]]	+	[[Category: Veverka, V]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription elongation]]

OCA at 06:17, 1 December 2021

OCA — Wed, 01 Dec 2021 06:17:19 GMT

←Older revision		Revision as of 06:17, 1 December 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6zv4 ~~is ON HOLD until Paper Publication~~	+	==Human TFIIS N-terminal domain in complex with IWS1==
-		+	<StructureSection load='6zv4' size='340' side='right'caption='[[6zv4]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Veverka V]]

OCA at 03:58, 5 August 2020

OCA — Wed, 05 Aug 2020 03:58:18 GMT

←Older revision		Revision as of 03:58, 5 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zv4 is ON HOLD	+	The entry 6zv4 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6zv4" [edit=sysop:move=sysop]

OCA — Wed, 29 Jul 2020 09:38:42 GMT

Protected "6zv4" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:38, 29 July 2020

OCA: New page: '''Unreleased structure''' The entry 6zv4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Jul 2020 09:38:40 GMT

New page: '''Unreleased structure''' The entry 6zv4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6zv4 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]