6zzm - Revision history

OCA at 12:00, 1 February 2024

OCA — Thu, 01 Feb 2024 12:00:56 GMT

←Older revision		Revision as of 12:00, 1 February 2024
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	<StructureSection load='6zzm' size='340' side='right'caption='[[6zzm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6zzm' size='340' side='right'caption='[[6zzm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6zzm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ccug_57279 Ccug 57279~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zzm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_mustelae Corynebacterium mustelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~aceF, CMUST_11075 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=571915 CCUG 57279])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zzm OCA], [https://pdbe.org/6zzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zzm RCSB], [https://www.ebi.ac.uk/pdbsum/6zzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zzm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zzm OCA], [https://pdbe.org/6zzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zzm RCSB], [https://www.ebi.ac.uk/pdbsum/6zzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zzm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0G3H170_9CORY A0A0G3H170_9CORY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6zzm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6zzm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydrolipoamide acetyltransferase 3D structures\|Dihydrolipoamide acetyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ccug 57279~~]]	+	[[Category: Corynebacterium mustelae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bellinzoni, M]]	+	[[Category: Bellinzoni M]]
-	[[Category: Bruch~~, E M]]~~	+	[[Category: Bruch EM]]
-	~~[[Category: Acetyltransferase]]~~	+
-	~~[[Category: Coa]]~~	+
-	~~[[Category: Corynebacterium]]~~	+
-	~~[[Category: Lipoamide]]~~	+
-	~~[[Category: Odh]]~~	+
-	~~[[Category: Pdh]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:54, 15 December 2021

OCA — Wed, 15 Dec 2021 16:54:20 GMT

←Older revision		Revision as of 16:54, 15 December 2021
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-	==Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)==	+	==Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p).==
	<StructureSection load='6zzm' size='340' side='right'caption='[[6zzm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6zzm' size='340' side='right'caption='[[6zzm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 10:02, 8 December 2021

OCA — Wed, 08 Dec 2021 10:02:35 GMT

←Older revision		Revision as of 10:02, 8 December 2021
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	==Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)==		==Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)==
-	<StructureSection load='6zzm' size='340' side='right'caption='[[6zzm]]' scene=''>	+	<StructureSection load='6zzm' size='340' side='right'caption='[[6zzm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6zzm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ccug_57279 Ccug 57279]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zzm OCA], [https://pdbe.org/6zzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zzm RCSB], [https://www.ebi.ac.uk/pdbsum/6zzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zzm ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aceF, CMUST_11075 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=571915 CCUG 57279])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zzm OCA], [https://pdbe.org/6zzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zzm RCSB], [https://www.ebi.ac.uk/pdbsum/6zzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zzm ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	alpha-oxoacid dehydrogenase complexes are large, tripartite enzymatic machineries carrying out key reactions in central metabolism. Extremely conserved across the tree of life, they have been, so far, all considered to be structured around a high-molecular weight hollow core, consisting of up to 60 subunits of the acyltransferase component. We provide here evidence that Actinobacteria break the rule by possessing an acetyltranferase component reduced to its minimally active, trimeric unit, characterized by a unique C-terminal helix bearing an actinobacterial specific insertion that precludes larger protein oligomerization. This particular feature, together with the presence of an odhA gene coding for both the decarboxylase and the acyltransferase domains on the same polypetide, is spread over Actinobacteria and reflects the association of PDH and ODH into a single physical complex. Considering the central role of the pyruvate and 2-oxoglutarate nodes in central metabolism, our findings pave the way to both therapeutic and metabolic engineering applications.
		+
		+	Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.,Bruch EM, Vilela P, Yang L, Boyko A, Lexa-Sapart N, Raynal B, Alzari PM, Bellinzoni M Proc Natl Acad Sci U S A. 2021 Nov 30;118(48). pii: 2112107118. doi:, 10.1073/pnas.2112107118. PMID:34819376<ref>PMID:34819376</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6zzm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ccug 57279]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bellinzoni M]]	+	[[Category: Bellinzoni, M]]
-	[[Category: Bruch EM]]	+	[[Category: Bruch, E M]]
		+	[[Category: Acetyltransferase]]
		+	[[Category: Coa]]
		+	[[Category: Corynebacterium]]
		+	[[Category: Lipoamide]]
		+	[[Category: Odh]]
		+	[[Category: Pdh]]
		+	[[Category: Transferase]]

OCA at 06:06, 18 August 2021

OCA — Wed, 18 Aug 2021 06:06:23 GMT

←Older revision		Revision as of 06:06, 18 August 2021
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-	'''Unreleased structure'''

-	~~The entry 6zzm is ON HOLD until Paper Publication~~	+	==Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)==
-		+	<StructureSection load='6zzm' size='340' side='right'caption='[[6zzm]]' scene=''>
-	~~Authors: Bruch, E.M., Bellinzoni, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZM FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zzm OCA], [https://pdbe.org/6zzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zzm RCSB], [https://www.ebi.ac.uk/pdbsum/6zzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zzm ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Bellinzoni, M]]	+	__TOC__
-	[[Category: Bruch~~, E.M~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bellinzoni M]]
		+	[[Category: Bruch EM]]

OCA at 05:00, 2 September 2020

OCA — Wed, 02 Sep 2020 05:00:29 GMT

←Older revision		Revision as of 05:00, 2 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6zzm is ON HOLD	+	The entry 6zzm is ON HOLD until Paper Publication

	Authors: Bruch, E.M., Bellinzoni, M.		Authors: Bruch, E.M., Bellinzoni, M.
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	Description: Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)		Description: Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bruch, E.M]]
	[[Category: Bellinzoni, M]]		[[Category: Bellinzoni, M]]
		+	[[Category: Bruch, E.M]]

OCA: Protected "6zzm" [edit=sysop:move=sysop]

OCA — Wed, 12 Aug 2020 08:17:25 GMT

Protected "6zzm" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:17, 12 August 2020

OCA: New page: '''Unreleased structure''' The entry 6zzm is ON HOLD Authors: Bruch, E.M., Bellinzoni, M. Description: Crystal structure of the catalytic domain of Corynebacterium mustelae predicted a...

OCA — Wed, 12 Aug 2020 08:17:24 GMT

New page: '''Unreleased structure''' The entry 6zzm is ON HOLD Authors: Bruch, E.M., Bellinzoni, M. Description: Crystal structure of the catalytic domain of Corynebacterium mustelae predicted a...

New page

'''Unreleased structure'''

The entry 6zzm is ON HOLD

Authors: Bruch, E.M., Bellinzoni, M.

Description: Crystal structure of the catalytic domain of Corynebacterium mustelae predicted acetyltransferase AceF (E2p)
[[Category: Unreleased Structures]]
[[Category: Bruch, E.M]]
[[Category: Bellinzoni, M]]