7a32 - Revision history

OCA at 12:02, 1 February 2024

OCA — Thu, 01 Feb 2024 12:02:51 GMT

←Older revision		Revision as of 12:02, 1 February 2024
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	==Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0==		==Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0==
-	<StructureSection load='7a32' size='340' side='right'caption='[[7a32]]' scene=''>	+	<StructureSection load='7a32' size='340' side='right'caption='[[7a32]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A32 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7a32]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A32 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a32 OCA], [https://pdbe.org/7a32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a32 RCSB], [https://www.ebi.ac.uk/pdbsum/7a32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a32 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a32 OCA], [https://pdbe.org/7a32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a32 RCSB], [https://www.ebi.ac.uk/pdbsum/7a32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a32 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SRC_CHICK SRC_CHICK] Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process. When cells adhere via focal adhesions to the extra-cellular matrix, signals are transmitted by integrins into the cell and result in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus.<ref>PMID:1717492</ref> <ref>PMID:8550628</ref>
		+
		+	==See Also==
		+	*[[Tyrosine kinase 3D structures\|Tyrosine kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Camara-Artigas A]]		[[Category: Camara-Artigas A]]
	[[Category: Plaza-Garrido M]]		[[Category: Plaza-Garrido M]]
	[[Category: Salinas-Garcia MC]]		[[Category: Salinas-Garcia MC]]

OCA at 06:16, 25 August 2021

OCA — Wed, 25 Aug 2021 06:16:57 GMT

←Older revision		Revision as of 06:16, 25 August 2021
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-	'''Unreleased structure'''

-	~~The entry 7a32 is ON HOLD until Paper Publication~~	+	==Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0==
-		+	<StructureSection load='7a32' size='340' side='right'caption='[[7a32]]' scene=''>
-	~~Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A32 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a32 OCA], [https://pdbe.org/7a32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a32 RCSB], [https://www.ebi.ac.uk/pdbsum/7a32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a32 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Plaza~~-~~Garrido~~, M]]	+	__TOC__
-	[[Category: Camara-Artigas, A]]	+	</StructureSection>
-	[[Category: Salinas-Garcia~~, M.C~~]]	+	[[Category: Large Structures]]
		+	[[Category: Camara-Artigas A]]
		+	[[Category: Plaza-Garrido M]]
		+	[[Category: Salinas-Garcia MC]]

OCA at 06:38, 16 September 2020

OCA — Wed, 16 Sep 2020 06:38:12 GMT

←Older revision		Revision as of 06:38, 16 September 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7a32 is ON HOLD	+	The entry 7a32 is ON HOLD until Paper Publication

	Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.		Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.
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	Description: Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0		Description: Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Salinas-Garcia, M.C]]
-	[[Category: Camara-Artigas, A]]
	[[Category: Plaza-Garrido, M]]		[[Category: Plaza-Garrido, M]]
		+	[[Category: Camara-Artigas, A]]
		+	[[Category: Salinas-Garcia, M.C]]

OCA: Protected "7a32" [edit=sysop:move=sysop]

OCA — Wed, 26 Aug 2020 09:14:54 GMT

Protected "7a32" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:14, 26 August 2020

OCA: New page: '''Unreleased structure''' The entry 7a32 is ON HOLD Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C. Description: Crystal structure of the c-Src SH3 domain mutant ...

OCA — Wed, 26 Aug 2020 09:14:53 GMT

New page: '''Unreleased structure''' The entry 7a32 is ON HOLD Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C. Description: Crystal structure of the c-Src SH3 domain mutant ...

New page

'''Unreleased structure'''

The entry 7a32 is ON HOLD

Authors: Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C.

Description: Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0
[[Category: Unreleased Structures]]
[[Category: Salinas-Garcia, M.C]]
[[Category: Camara-Artigas, A]]
[[Category: Plaza-Garrido, M]]